Salting-out thin-layer chromatography of some macrolide antibiotics
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The chromatographic behavior of roxithromycin, midecamycin, erythromycin, azithromycin, and erythromycin ethylsuccinate has been studied by salting-out thin-layer chromatography (SOTLC) with cellulose as a adsorbent and aqueous ammonium sulfate solutions of different concentration as mobile phases. Hydrophobicity was determined from the linear relationships between solute R-M values and the ammonium sulfate content of the mobile phase. Hydrophobicity values R-M(0) and C-0 were calculated on the basis of the results obtained. Lipophilicity determined in this way was correlated with calculated log P values.
Keywords:salting-out thin-layer chromatography (SOTLC) / macrolide antibiotics / cellulose / hydrophobicity
Source:Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography, 2005, 18, 106, 415-418
- Research Inst Medicinal Plants, Budakalasz