Reactivity and biological activity of the marine sesquiterpene hydroquinone avarol and related compounds from sponges of the order Dictyoceratida
Abstract
A review of results of bioactivity and reactivity examinations of marine sesquiterpene (hydro)quinones is presented. The article is focused mostly on friedo-rearranged drimane structural types, isolated from sponges of the order Dictyoceratida. Examples of structural correlations are outlined. Available results on the mechanism of redox processes and examinations of chemo- and regioselectivity in addition reactions are presented and, where possible, analyzed in relation to established bioactivities. Most of the bioactivity examinations are concerned with antitumor activities and the mechanism thereof, such as DNA damage, arylation of nucleophiles, tubulin assembly inhibition, protein kinase inhibition, inhibition of the arachidonic cascade, etc. Perspectives on marine drug development are discussed with respect to biotechnological methods and synthesis. Examples of the recognition of validated core structures and synthesis of structurally simplified compounds retaining modes of activit...y are analyzed.
Keywords:
sponges / sesquiterpene / quinone / hydroquinone / bioactivitySource:
Molecules, 2006, 11, 1, 1-33Publisher:
- Mdpi Ag, Basel
DOI: 10.3390/11010001
ISSN: 1420-3049
PubMed: 17962742
WoS: 000236353300001
Scopus: 2-s2.0-33644794482
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Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Sladić, Dušan AU - Gasic, MJ PY - 2006 UR - https://cherry.chem.bg.ac.rs/handle/123456789/769 AB - A review of results of bioactivity and reactivity examinations of marine sesquiterpene (hydro)quinones is presented. The article is focused mostly on friedo-rearranged drimane structural types, isolated from sponges of the order Dictyoceratida. Examples of structural correlations are outlined. Available results on the mechanism of redox processes and examinations of chemo- and regioselectivity in addition reactions are presented and, where possible, analyzed in relation to established bioactivities. Most of the bioactivity examinations are concerned with antitumor activities and the mechanism thereof, such as DNA damage, arylation of nucleophiles, tubulin assembly inhibition, protein kinase inhibition, inhibition of the arachidonic cascade, etc. Perspectives on marine drug development are discussed with respect to biotechnological methods and synthesis. Examples of the recognition of validated core structures and synthesis of structurally simplified compounds retaining modes of activity are analyzed. PB - Mdpi Ag, Basel T2 - Molecules T1 - Reactivity and biological activity of the marine sesquiterpene hydroquinone avarol and related compounds from sponges of the order Dictyoceratida VL - 11 IS - 1 SP - 1 EP - 33 DO - 10.3390/11010001 ER -
@article{ author = "Sladić, Dušan and Gasic, MJ", year = "2006", abstract = "A review of results of bioactivity and reactivity examinations of marine sesquiterpene (hydro)quinones is presented. The article is focused mostly on friedo-rearranged drimane structural types, isolated from sponges of the order Dictyoceratida. Examples of structural correlations are outlined. Available results on the mechanism of redox processes and examinations of chemo- and regioselectivity in addition reactions are presented and, where possible, analyzed in relation to established bioactivities. Most of the bioactivity examinations are concerned with antitumor activities and the mechanism thereof, such as DNA damage, arylation of nucleophiles, tubulin assembly inhibition, protein kinase inhibition, inhibition of the arachidonic cascade, etc. Perspectives on marine drug development are discussed with respect to biotechnological methods and synthesis. Examples of the recognition of validated core structures and synthesis of structurally simplified compounds retaining modes of activity are analyzed.", publisher = "Mdpi Ag, Basel", journal = "Molecules", title = "Reactivity and biological activity of the marine sesquiterpene hydroquinone avarol and related compounds from sponges of the order Dictyoceratida", volume = "11", number = "1", pages = "1-33", doi = "10.3390/11010001" }
Sladić, D.,& Gasic, M.. (2006). Reactivity and biological activity of the marine sesquiterpene hydroquinone avarol and related compounds from sponges of the order Dictyoceratida. in Molecules Mdpi Ag, Basel., 11(1), 1-33. https://doi.org/10.3390/11010001
Sladić D, Gasic M. Reactivity and biological activity of the marine sesquiterpene hydroquinone avarol and related compounds from sponges of the order Dictyoceratida. in Molecules. 2006;11(1):1-33. doi:10.3390/11010001 .
Sladić, Dušan, Gasic, MJ, "Reactivity and biological activity of the marine sesquiterpene hydroquinone avarol and related compounds from sponges of the order Dictyoceratida" in Molecules, 11, no. 1 (2006):1-33, https://doi.org/10.3390/11010001 . .