Show simple item record

dc.creatorSladić, Dušan
dc.creatorGasic, MJ
dc.date.accessioned2018-11-22T00:09:33Z
dc.date.available2018-11-22T00:09:33Z
dc.date.issued2006
dc.identifier.issn1420-3049
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/769
dc.description.abstractA review of results of bioactivity and reactivity examinations of marine sesquiterpene (hydro)quinones is presented. The article is focused mostly on friedo-rearranged drimane structural types, isolated from sponges of the order Dictyoceratida. Examples of structural correlations are outlined. Available results on the mechanism of redox processes and examinations of chemo- and regioselectivity in addition reactions are presented and, where possible, analyzed in relation to established bioactivities. Most of the bioactivity examinations are concerned with antitumor activities and the mechanism thereof, such as DNA damage, arylation of nucleophiles, tubulin assembly inhibition, protein kinase inhibition, inhibition of the arachidonic cascade, etc. Perspectives on marine drug development are discussed with respect to biotechnological methods and synthesis. Examples of the recognition of validated core structures and synthesis of structurally simplified compounds retaining modes of activity are analyzed.en
dc.publisherMdpi Ag, Basel
dc.rightsopenAccess
dc.sourceMolecules
dc.subjectspongesen
dc.subjectsesquiterpeneen
dc.subjectquinoneen
dc.subjecthydroquinoneen
dc.subjectbioactivityen
dc.titleReactivity and biological activity of the marine sesquiterpene hydroquinone avarol and related compounds from sponges of the order Dictyoceratidaen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractГасиц, МЈ; Сладић, Душан;
dc.citation.volume11
dc.citation.issue1
dc.citation.spage1
dc.citation.epage33
dc.identifier.wos000236353300001
dc.identifier.doi10.3390/11010001
dc.citation.other11(1): 1-33
dc.citation.rankM23
dc.identifier.pmid17962742
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-33644794482
dc.identifier.fulltexthttp://cherry.chem.bg.ac.rs/bitstream/id/9983/767.pdf
dc.identifier.rcubKon_1722


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record