Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9 11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9 alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound. (c) 2006 Elsevier Ltd. All rights reserved.
TY - JOUR
AU - Trifunović, Snežana S.
AU - Vajs, Vlatka
AU - Juranić, Zorica D.
AU - Žižak, Željko S.
AU - Tešević, Vele
AU - Macura, Slobodan
AU - Milosavljević, Slobodan M.
PY - 2006
UR - https://cherry.chem.bg.ac.rs/handle/123456789/779
AB - Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9 11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9 alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound. (c) 2006 Elsevier Ltd. All rights reserved.
PB - Pergamon-Elsevier Science Ltd, Oxford
T2 - Phytochemistry
T1 - Cytotoxic constituents of Achillea clavennae from Montenegro
VL - 67
IS - 9
SP - 887
EP - 893
DO - 10.1016/j.phytochem.2006.02.026
UR - Kon_1732
ER -
@article{
author = "Trifunović, Snežana S. and Vajs, Vlatka and Juranić, Zorica D. and Žižak, Željko S. and Tešević, Vele and Macura, Slobodan and Milosavljević, Slobodan M.",
year = "2006",
abstract = "Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9 11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9 alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound. (c) 2006 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Phytochemistry",
title = "Cytotoxic constituents of Achillea clavennae from Montenegro",
volume = "67",
number = "9",
pages = "887-893",
doi = "10.1016/j.phytochem.2006.02.026",
url = "Kon_1732"
}
Trifunović, S. S., Vajs, V., Juranić, Z. D., Žižak, Ž. S., Tešević, V., Macura, S.,& Milosavljević, S. M.. (2006). Cytotoxic constituents of Achillea clavennae from Montenegro. in Phytochemistry
Pergamon-Elsevier Science Ltd, Oxford., 67(9), 887-893.
https://doi.org/10.1016/j.phytochem.2006.02.026
Kon_1732
Trifunović SS, Vajs V, Juranić ZD, Žižak ŽS, Tešević V, Macura S, Milosavljević SM. Cytotoxic constituents of Achillea clavennae from Montenegro. in Phytochemistry. 2006;67(9):887-893.
doi:10.1016/j.phytochem.2006.02.026
Kon_1732 .
Trifunović, Snežana S., Vajs, Vlatka, Juranić, Zorica D., Žižak, Željko S., Tešević, Vele, Macura, Slobodan, Milosavljević, Slobodan M., "Cytotoxic constituents of Achillea clavennae from Montenegro" in Phytochemistry, 67, no. 9 (2006):887-893,
https://doi.org/10.1016/j.phytochem.2006.02.026 .,
Kon_1732 .
