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Cytotoxic constituents of Achillea clavennae from Montenegro

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2006
Authors
Trifunović, Snežana S.
Vajs, Vlatka
Juranić, Zorica D.
Žižak, Željko S.
Tešević, Vele
Macura, Slobodan
Milosavljević, Slobodan M.
Article (Published version)
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Abstract
Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9 11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9 alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound. (c) 2006 Elsevier Ltd. All rights reserved.
Keywords:
Achillea clavennae / Asteraceae / guaianolides / bisabolenes / flavonoids / cytotoxicity
Source:
Phytochemistry, 2006, 67, 9, 887-893
Publisher:
  • Pergamon-Elsevier Science Ltd, Oxford
Funding / projects:
  • Sekundarni metaboliti samoniklih, lekovitih biljaka: izolovanje, karakterizacija i biloška aktivnost (RS-142053)
  • Istraživanje dejstava modifikatora biološkog odgovora u fiziološkim i patološkim stanjima (RS-145006)

DOI: 10.1016/j.phytochem.2006.02.026

ISSN: 0031-9422

PubMed: 16616262

WoS: 000237600300007

Scopus: 2-s2.0-33646072788
[ Google Scholar ]
68
62
URI
https://cherry.chem.bg.ac.rs/handle/123456789/779
Collections
  • Publikacije
Institution/Community
Hemijski fakultet
TY  - JOUR
AU  - Trifunović, Snežana S.
AU  - Vajs, Vlatka
AU  - Juranić, Zorica D.
AU  - Žižak, Željko S.
AU  - Tešević, Vele
AU  - Macura, Slobodan
AU  - Milosavljević, Slobodan M.
PY  - 2006
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/779
AB  - Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9 11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9 alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound. (c) 2006 Elsevier Ltd. All rights reserved.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Phytochemistry
T1  - Cytotoxic constituents of Achillea clavennae from Montenegro
VL  - 67
IS  - 9
SP  - 887
EP  - 893
DO  - 10.1016/j.phytochem.2006.02.026
UR  - Kon_1732
ER  - 
@article{
author = "Trifunović, Snežana S. and Vajs, Vlatka and Juranić, Zorica D. and Žižak, Željko S. and Tešević, Vele and Macura, Slobodan and Milosavljević, Slobodan M.",
year = "2006",
abstract = "Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9 11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9 alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound. (c) 2006 Elsevier Ltd. All rights reserved.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Phytochemistry",
title = "Cytotoxic constituents of Achillea clavennae from Montenegro",
volume = "67",
number = "9",
pages = "887-893",
doi = "10.1016/j.phytochem.2006.02.026",
url = "Kon_1732"
}
Trifunović, S. S., Vajs, V., Juranić, Z. D., Žižak, Ž. S., Tešević, V., Macura, S.,& Milosavljević, S. M.. (2006). Cytotoxic constituents of Achillea clavennae from Montenegro. in Phytochemistry
Pergamon-Elsevier Science Ltd, Oxford., 67(9), 887-893.
https://doi.org/10.1016/j.phytochem.2006.02.026
Kon_1732
Trifunović SS, Vajs V, Juranić ZD, Žižak ŽS, Tešević V, Macura S, Milosavljević SM. Cytotoxic constituents of Achillea clavennae from Montenegro. in Phytochemistry. 2006;67(9):887-893.
doi:10.1016/j.phytochem.2006.02.026
Kon_1732 .
Trifunović, Snežana S., Vajs, Vlatka, Juranić, Zorica D., Žižak, Željko S., Tešević, Vele, Macura, Slobodan, Milosavljević, Slobodan M., "Cytotoxic constituents of Achillea clavennae from Montenegro" in Phytochemistry, 67, no. 9 (2006):887-893,
https://doi.org/10.1016/j.phytochem.2006.02.026 .,
Kon_1732 .

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