Cytotoxic constituents of Achillea clavennae from Montenegro
Authorized Users Only
2006
Authors
Trifunović, Snežana S.Vajs, Vlatka
Juranić, Zorica D.
Žižak, Željko S.
Tešević, Vele
Macura, Slobodan
Milosavljević, Slobodan M.
Article (Published version)
Metadata
Show full item recordAbstract
Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9 11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9 alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound. (c) 2006 Elsevier Ltd. All rights reserved.
Keywords:
Achillea clavennae / Asteraceae / guaianolides / bisabolenes / flavonoids / cytotoxicitySource:
Phytochemistry, 2006, 67, 9, 887-893Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
Funding / projects:
- Sekundarni metaboliti samoniklih, lekovitih biljaka: izolovanje, karakterizacija i biloška aktivnost (RS-MESTD-MPN2006-2010-142053)
- Istraživanje dejstava modifikatora biološkog odgovora u fiziološkim i patološkim stanjima (RS-MESTD-MPN2006-2010-145006)
DOI: 10.1016/j.phytochem.2006.02.026
ISSN: 0031-9422
PubMed: 16616262
WoS: 000237600300007
Scopus: 2-s2.0-33646072788
Collections
Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Trifunović, Snežana S. AU - Vajs, Vlatka AU - Juranić, Zorica D. AU - Žižak, Željko S. AU - Tešević, Vele AU - Macura, Slobodan AU - Milosavljević, Slobodan M. PY - 2006 UR - https://cherry.chem.bg.ac.rs/handle/123456789/779 AB - Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9 11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9 alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound. (c) 2006 Elsevier Ltd. All rights reserved. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Phytochemistry T1 - Cytotoxic constituents of Achillea clavennae from Montenegro VL - 67 IS - 9 SP - 887 EP - 893 DO - 10.1016/j.phytochem.2006.02.026 ER -
@article{ author = "Trifunović, Snežana S. and Vajs, Vlatka and Juranić, Zorica D. and Žižak, Željko S. and Tešević, Vele and Macura, Slobodan and Milosavljević, Slobodan M.", year = "2006", abstract = "Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1-8), three bisabolenes (9 11), four flavonols (12-15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9 alpha-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound. (c) 2006 Elsevier Ltd. All rights reserved.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Phytochemistry", title = "Cytotoxic constituents of Achillea clavennae from Montenegro", volume = "67", number = "9", pages = "887-893", doi = "10.1016/j.phytochem.2006.02.026" }
Trifunović, S. S., Vajs, V., Juranić, Z. D., Žižak, Ž. S., Tešević, V., Macura, S.,& Milosavljević, S. M.. (2006). Cytotoxic constituents of Achillea clavennae from Montenegro. in Phytochemistry Pergamon-Elsevier Science Ltd, Oxford., 67(9), 887-893. https://doi.org/10.1016/j.phytochem.2006.02.026
Trifunović SS, Vajs V, Juranić ZD, Žižak ŽS, Tešević V, Macura S, Milosavljević SM. Cytotoxic constituents of Achillea clavennae from Montenegro. in Phytochemistry. 2006;67(9):887-893. doi:10.1016/j.phytochem.2006.02.026 .
Trifunović, Snežana S., Vajs, Vlatka, Juranić, Zorica D., Žižak, Željko S., Tešević, Vele, Macura, Slobodan, Milosavljević, Slobodan M., "Cytotoxic constituents of Achillea clavennae from Montenegro" in Phytochemistry, 67, no. 9 (2006):887-893, https://doi.org/10.1016/j.phytochem.2006.02.026 . .