Cytotoxic activity of four series of coordinated complexes of Zn(II) and Fe(II) with hydrazone/hydrazide ligands against HeLa and B16 cells was evaluated. The ligands N',N'(2)-bis [(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (H(2)L1) and N,N'(2)-bis[(1E)-1-(2-pyridyl) ethylidene]propanedihydrazide (H(2)L2) and their Zn(II) complexes showed IC50 values in the low micromolar range, while the other ligands and complexes were less active or inactive.
Keywords:
cytotoxic activity / hydrazone / transition metal complexes
TY - JOUR
AU - Lazić, M.
AU - Radulović, Siniša
AU - Todorović, Tamara
AU - Sladić, Dušan
AU - Tešić, Živoslav Lj.
AU - Anđelković, Katarina K.
PY - 2006
UR - https://cherry.chem.bg.ac.rs/handle/123456789/790
AB - Cytotoxic activity of four series of coordinated complexes of Zn(II) and Fe(II) with hydrazone/hydrazide ligands against HeLa and B16 cells was evaluated. The ligands N',N'(2)-bis [(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (H(2)L1) and N,N'(2)-bis[(1E)-1-(2-pyridyl) ethylidene]propanedihydrazide (H(2)L2) and their Zn(II) complexes showed IC50 values in the low micromolar range, while the other ligands and complexes were less active or inactive.
PB - Trans Tech Publications Ltd, Zurich-Uetikon
T2 - Materials Science Forum
T1 - Evaluation of cytotoxic activity of d-metal complexes with hydrazone ligands
VL - 518
SP - 513
EP - 517
DO - 10.4028/www.scientific.net/MSF.518.513
UR - Kon_1743
ER -
@article{
author = "Lazić, M. and Radulović, Siniša and Todorović, Tamara and Sladić, Dušan and Tešić, Živoslav Lj. and Anđelković, Katarina K.",
year = "2006",
abstract = "Cytotoxic activity of four series of coordinated complexes of Zn(II) and Fe(II) with hydrazone/hydrazide ligands against HeLa and B16 cells was evaluated. The ligands N',N'(2)-bis [(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (H(2)L1) and N,N'(2)-bis[(1E)-1-(2-pyridyl) ethylidene]propanedihydrazide (H(2)L2) and their Zn(II) complexes showed IC50 values in the low micromolar range, while the other ligands and complexes were less active or inactive.",
publisher = "Trans Tech Publications Ltd, Zurich-Uetikon",
journal = "Materials Science Forum",
title = "Evaluation of cytotoxic activity of d-metal complexes with hydrazone ligands",
volume = "518",
pages = "513-517",
doi = "10.4028/www.scientific.net/MSF.518.513",
url = "Kon_1743"
}
Lazić, M., Radulović, S., Todorović, T., Sladić, D., Tešić, Ž. Lj.,& Anđelković, K. K.. (2006). Evaluation of cytotoxic activity of d-metal complexes with hydrazone ligands. in Materials Science Forum
Trans Tech Publications Ltd, Zurich-Uetikon., 518, 513-517.
https://doi.org/10.4028/www.scientific.net/MSF.518.513
Kon_1743
Lazić M, Radulović S, Todorović T, Sladić D, Tešić ŽL, Anđelković KK. Evaluation of cytotoxic activity of d-metal complexes with hydrazone ligands. in Materials Science Forum. 2006;518:513-517.
doi:10.4028/www.scientific.net/MSF.518.513
Kon_1743 .
Lazić, M., Radulović, Siniša, Todorović, Tamara, Sladić, Dušan, Tešić, Živoslav Lj., Anđelković, Katarina K., "Evaluation of cytotoxic activity of d-metal complexes with hydrazone ligands" in Materials Science Forum, 518 (2006):513-517,
https://doi.org/10.4028/www.scientific.net/MSF.518.513 .,
Kon_1743 .
