Synthesis, biology, and modeling of a C-4 carbonyl C,D-seco-taxoid
Само за регистроване кориснике
2006
Аутори
Ferjančić, ZoranaMatović, Radomir
Čeković, Živorad
Jiang, Yi
Snyder, James P.
Trajković, Vladimir S.
Saičić, Radomir
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A C,D-seco-paclitaxel derivative 26 was prepared from taxine and tested for biological activity. Chemical reactivity of the seco-compounds proved to be substantially modified, with respects to taxoids. The corresponding C,D-seco-taxoid does not show tubulin stabilizing activity or cytotoxicity. Explanation of these observations based on molecular modeling is provided. (c) 2006 Elsevier Ltd. All rights reserved.
Кључне речи:
taxane antitumor agents / radicals and radical reactions / medium sized rings / natural products / molecular modelingИзвор:
Tetrahedron, 2006, 62, 36, 8503-8514Издавач:
- Pergamon-Elsevier Science Ltd, Oxford
DOI: 10.1016/j.tet.2006.06.080
ISSN: 0040-4020
WoS: 000240125700010
Scopus: 2-s2.0-33746306276
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Ferjančić, Zorana AU - Matović, Radomir AU - Čeković, Živorad AU - Jiang, Yi AU - Snyder, James P. AU - Trajković, Vladimir S. AU - Saičić, Radomir PY - 2006 UR - https://cherry.chem.bg.ac.rs/handle/123456789/798 AB - A C,D-seco-paclitaxel derivative 26 was prepared from taxine and tested for biological activity. Chemical reactivity of the seco-compounds proved to be substantially modified, with respects to taxoids. The corresponding C,D-seco-taxoid does not show tubulin stabilizing activity or cytotoxicity. Explanation of these observations based on molecular modeling is provided. (c) 2006 Elsevier Ltd. All rights reserved. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Tetrahedron T1 - Synthesis, biology, and modeling of a C-4 carbonyl C,D-seco-taxoid VL - 62 IS - 36 SP - 8503 EP - 8514 DO - 10.1016/j.tet.2006.06.080 ER -
@article{ author = "Ferjančić, Zorana and Matović, Radomir and Čeković, Živorad and Jiang, Yi and Snyder, James P. and Trajković, Vladimir S. and Saičić, Radomir", year = "2006", abstract = "A C,D-seco-paclitaxel derivative 26 was prepared from taxine and tested for biological activity. Chemical reactivity of the seco-compounds proved to be substantially modified, with respects to taxoids. The corresponding C,D-seco-taxoid does not show tubulin stabilizing activity or cytotoxicity. Explanation of these observations based on molecular modeling is provided. (c) 2006 Elsevier Ltd. All rights reserved.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Tetrahedron", title = "Synthesis, biology, and modeling of a C-4 carbonyl C,D-seco-taxoid", volume = "62", number = "36", pages = "8503-8514", doi = "10.1016/j.tet.2006.06.080" }
Ferjančić, Z., Matović, R., Čeković, Ž., Jiang, Y., Snyder, J. P., Trajković, V. S.,& Saičić, R.. (2006). Synthesis, biology, and modeling of a C-4 carbonyl C,D-seco-taxoid. in Tetrahedron Pergamon-Elsevier Science Ltd, Oxford., 62(36), 8503-8514. https://doi.org/10.1016/j.tet.2006.06.080
Ferjančić Z, Matović R, Čeković Ž, Jiang Y, Snyder JP, Trajković VS, Saičić R. Synthesis, biology, and modeling of a C-4 carbonyl C,D-seco-taxoid. in Tetrahedron. 2006;62(36):8503-8514. doi:10.1016/j.tet.2006.06.080 .
Ferjančić, Zorana, Matović, Radomir, Čeković, Živorad, Jiang, Yi, Snyder, James P., Trajković, Vladimir S., Saičić, Radomir, "Synthesis, biology, and modeling of a C-4 carbonyl C,D-seco-taxoid" in Tetrahedron, 62, no. 36 (2006):8503-8514, https://doi.org/10.1016/j.tet.2006.06.080 . .