Приказ основних података о документу

Uticaj osobina N-1 supstituenta na afinitet arilpiperazina prema vezivnom mestu 5-HT1A receptora

dc.creatorZlatović, Mario
dc.creatorŠukalović, Vladimir
dc.creatorKostić-Rajačić, Slađana
dc.creatorAndrić, Deana
dc.creatorRoglić, Goran
dc.date.accessioned2018-11-22T00:10:20Z
dc.date.available2018-11-22T00:10:20Z
dc.date.issued2006
dc.identifier.issn0352-5139
dc.identifier.urihttps://cherry.chem.bg.ac.rs/handle/123456789/818
dc.description.abstractScrotonin receptors (5-HTRs), especially the 5-HT1A subtype, have been the subject of intensive research for the past decade, due to their function in human physiology. Several structurally different classes of ligands are known to bind to the 5-HT1A receptor, but arylpiperazine derivatives are among the most important ligands. In the work, docking analyses were used to explain the binding affinities of a series of ligands with different N-1 substituent. All ligands had ill common the arylpiperazine structure, while the N-1 substituent was modified to investigate the influence of ligand structure on its binding affinity. The shape and size, as well as the rigidity of the substituents were altered to investigate the possible effects on the formation of the receptor - ligand complex.en
dc.description.abstractSerotoninski receptori su, a naročito 5-HT 1A pod tip, zbog značajne uloge u fiziologiji ljudskog organizma, predmet intenzivnog izučavanja tokom protekle decenije. Poznato je da se za 5-HT 1A receptor vezuje nekoliko strukturno različitih klasa liganada, ali su arilpiperazinski derivati među najznačajnijim. Da bi objasnili vezivanje serije liganada sa različitim N-1 supstituentima za receptor koristili smo analizu vezivanja (docking analizu). Svi ligandi su imali zajedničku arilpiperazinsku strukturu dok su im N-1 supstituenti modifikovani tako što je menjan oblik, veličina kao i krutost supstituenta da bi se istražio njihov eventualni uticaj na formiranje kompleksa receptor - ligand.sr
dc.publisherSerbian Chemical Soc, Belgrade
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142009/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of the Serbian Chemical Society
dc.subject5-HT1Aen
dc.subjectbinding siteen
dc.subjectbinding siteen
dc.subjecthydrophobic pocketen
dc.subjecthydrophobic pocketen
dc.subjectarylpiperazineen
dc.subjectarylpiperazineen
dc.titleInfluence of N-1 substituent properties on binding affinities of arylpiperazines to the binding site of 5-HT1A receptoren
dc.titleUticaj osobina N-1 supstituenta na afinitet arilpiperazina prema vezivnom mestu 5-HT1A receptorasr
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractРоглић, Горан; Сукаловиц, Владимир В.; Костиц-Рајациц, Сладана В.; Златовић, Марио; Aндрић, Деана; Утицај особина Н-1 супституента на афинитет арилпиперазина према везивном месту 5-ХТ1A рецептора; Утицај особина Н-1 супституента на афинитет арилпиперазина према везивном месту 5-ХТ1A рецептора;
dc.citation.volume71
dc.citation.issue11
dc.citation.spage1125
dc.citation.epage1135
dc.identifier.wos000243619400001
dc.identifier.doi10.2298/JSC0611125Z
dc.citation.other71(11): 1125-1135
dc.citation.rankM23
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-33846330112
dc.identifier.fulltexthttps://cherry.chem.bg.ac.rs/bitstream/id/10018/816.pdf


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу