Evaluation of the activity of the sponge metabolites avarol and avarone and their synthetic derivatives against fouling micro- and macroorganisms
2007
Аутори
Tsoukatou, MariaMarechal, Jean Philippe
Hellio, Claire
Novaković, Irena T.
Tufegdzie, Srdan
Sladić, Dušan
Gasic, Miroslav J.
Clare, Anthony S.
Vagias, Constantinos
Roussis, Vassilios
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The sesquiterpene hydroquinone avarol (1) was isolated from the marine sponge Dysidea avara, whereas the corresponding quitione, avarone (2), was obtained by oxidation of avarol, and the significantly more lipophilic compounds [3 '-(P-chlorophenyl)avarone (3), 3 ',4 '-ethylenedithioavarone (4), 4 '-isopropylthioavarone (5), 4 '-tertbutylthioavarone (6), 4 '-propylthioavarone (7), 4 '-octylthioavarone (8)] were obtained by nucleophilic addition of thiols or p-chloroaniline to avarone. All these compounds were tested, at concentrations ranging from 0.5 to 50 mu g/mL, for their effect on the settlement of the cyprid stage of Balanus amphitrite, for toxicity to both nauplii and cyprids and for their growth inhibitory activity on marine bacteria (Cobetia marina, Marinobacterium stanieri, Vibrio fischeri and Pseudoalteromonas haloplanktis) and marine fungi (Halosphaeriopsis mediosetigera, Asteromyces cruciatus, Lulworthia uniseptata and Monodictys pelagica).
Кључне речи:
antifouling activity / settlement inhibition / antimicrobial activity / avarol / avaroneИзвор:
Molecules, 2007, 12, 5, 1022-1034Издавач:
- Mdpi Ag, Basel
DOI: 10.3390/12051022
ISSN: 1420-3049
PubMed: 17873837
WoS: 000247200900009
Scopus: 2-s2.0-34249870148
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Tsoukatou, Maria AU - Marechal, Jean Philippe AU - Hellio, Claire AU - Novaković, Irena T. AU - Tufegdzie, Srdan AU - Sladić, Dušan AU - Gasic, Miroslav J. AU - Clare, Anthony S. AU - Vagias, Constantinos AU - Roussis, Vassilios PY - 2007 UR - https://cherry.chem.bg.ac.rs/handle/123456789/840 AB - The sesquiterpene hydroquinone avarol (1) was isolated from the marine sponge Dysidea avara, whereas the corresponding quitione, avarone (2), was obtained by oxidation of avarol, and the significantly more lipophilic compounds [3 '-(P-chlorophenyl)avarone (3), 3 ',4 '-ethylenedithioavarone (4), 4 '-isopropylthioavarone (5), 4 '-tertbutylthioavarone (6), 4 '-propylthioavarone (7), 4 '-octylthioavarone (8)] were obtained by nucleophilic addition of thiols or p-chloroaniline to avarone. All these compounds were tested, at concentrations ranging from 0.5 to 50 mu g/mL, for their effect on the settlement of the cyprid stage of Balanus amphitrite, for toxicity to both nauplii and cyprids and for their growth inhibitory activity on marine bacteria (Cobetia marina, Marinobacterium stanieri, Vibrio fischeri and Pseudoalteromonas haloplanktis) and marine fungi (Halosphaeriopsis mediosetigera, Asteromyces cruciatus, Lulworthia uniseptata and Monodictys pelagica). PB - Mdpi Ag, Basel T2 - Molecules T1 - Evaluation of the activity of the sponge metabolites avarol and avarone and their synthetic derivatives against fouling micro- and macroorganisms VL - 12 IS - 5 SP - 1022 EP - 1034 DO - 10.3390/12051022 ER -
@article{ author = "Tsoukatou, Maria and Marechal, Jean Philippe and Hellio, Claire and Novaković, Irena T. and Tufegdzie, Srdan and Sladić, Dušan and Gasic, Miroslav J. and Clare, Anthony S. and Vagias, Constantinos and Roussis, Vassilios", year = "2007", abstract = "The sesquiterpene hydroquinone avarol (1) was isolated from the marine sponge Dysidea avara, whereas the corresponding quitione, avarone (2), was obtained by oxidation of avarol, and the significantly more lipophilic compounds [3 '-(P-chlorophenyl)avarone (3), 3 ',4 '-ethylenedithioavarone (4), 4 '-isopropylthioavarone (5), 4 '-tertbutylthioavarone (6), 4 '-propylthioavarone (7), 4 '-octylthioavarone (8)] were obtained by nucleophilic addition of thiols or p-chloroaniline to avarone. All these compounds were tested, at concentrations ranging from 0.5 to 50 mu g/mL, for their effect on the settlement of the cyprid stage of Balanus amphitrite, for toxicity to both nauplii and cyprids and for their growth inhibitory activity on marine bacteria (Cobetia marina, Marinobacterium stanieri, Vibrio fischeri and Pseudoalteromonas haloplanktis) and marine fungi (Halosphaeriopsis mediosetigera, Asteromyces cruciatus, Lulworthia uniseptata and Monodictys pelagica).", publisher = "Mdpi Ag, Basel", journal = "Molecules", title = "Evaluation of the activity of the sponge metabolites avarol and avarone and their synthetic derivatives against fouling micro- and macroorganisms", volume = "12", number = "5", pages = "1022-1034", doi = "10.3390/12051022" }
Tsoukatou, M., Marechal, J. P., Hellio, C., Novaković, I. T., Tufegdzie, S., Sladić, D., Gasic, M. J., Clare, A. S., Vagias, C.,& Roussis, V.. (2007). Evaluation of the activity of the sponge metabolites avarol and avarone and their synthetic derivatives against fouling micro- and macroorganisms. in Molecules Mdpi Ag, Basel., 12(5), 1022-1034. https://doi.org/10.3390/12051022
Tsoukatou M, Marechal JP, Hellio C, Novaković IT, Tufegdzie S, Sladić D, Gasic MJ, Clare AS, Vagias C, Roussis V. Evaluation of the activity of the sponge metabolites avarol and avarone and their synthetic derivatives against fouling micro- and macroorganisms. in Molecules. 2007;12(5):1022-1034. doi:10.3390/12051022 .
Tsoukatou, Maria, Marechal, Jean Philippe, Hellio, Claire, Novaković, Irena T., Tufegdzie, Srdan, Sladić, Dušan, Gasic, Miroslav J., Clare, Anthony S., Vagias, Constantinos, Roussis, Vassilios, "Evaluation of the activity of the sponge metabolites avarol and avarone and their synthetic derivatives against fouling micro- and macroorganisms" in Molecules, 12, no. 5 (2007):1022-1034, https://doi.org/10.3390/12051022 . .