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Ruthenium(II) complexes of thiosemicarbazones: The first Walter-soluble complex with pH-Dependent antiproliferative activity
dc.creator | Grgurić-Šipka, Sanja | |
dc.creator | Kowol, Christian R. | |
dc.creator | Valiahdi, Seied-Mojtaba | |
dc.creator | Eichinger, Rene | |
dc.creator | Jakupec, Michael A. | |
dc.creator | Roller, Alexander | |
dc.creator | Shova, Sergiu | |
dc.creator | Arion, Vladimir B. | |
dc.creator | Keppler, Bernhard K. | |
dc.date.accessioned | 2018-11-22T00:11:07Z | |
dc.date.available | 2018-11-22T00:11:07Z | |
dc.date.issued | 2007 | |
dc.identifier.issn | 1434-1948 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/849 | |
dc.description.abstract | Two ruthenium(II) complexes of 2-acetylpyridine N ',N '-dimethylthiosemicarbazone (HL1) and phenanthrenequinone thiosemicarbazone (HL2), namely [(RuCI)-C-II(L-1)(PPh3)(2)] (1) and [(RuCl)-Cl-II(L-2) (PPh3)(2)] (2), have been synthesised and characterised by IR, UV/Vis and NMR spectroscopy, electrospray mass spectrometry, cyclic voltammetry and X-ray crystallography. In addition, the X-ray crystal structure of [(RuCl2)-Cl-III(L-2)- PPh3]center dot dmso center dot 1.25H(2)O (3 center dot dmso center dot 1.25H(2)O) is reported. The reaction of [(RuCl2)-Cl-II(dmsO)(4)] with HL1 and 1,3,5-triaza-7-phosphaadamantane (PTA) gives the highly water-soluble complex [(RuCl)-Cl-II(L-1)(HPTA)(2)]Cl-2 center dot C2H5OH center dot H2O (4 center dot C2H5OH center dot H2O) (S-25 degrees C - gt = 250 mg/mL), which has been fully characterised. Complex 4 shows strong antiproliferative effects in low micromolar concentrations in the ovarian carcinoma cell line 41M (IC50 = 0.87 mu m) and more moderate activity in the breast cancer cell line SK-BR-3 (IC50 = 39 mu m). The activity of the compound is 6.5- and 5.4-times higher at pH = 6.0 than at pH = 7.4 in the non-small cell lung cancer cell line A549 and the colon carcinoma cell line HT-29 (GI(50) = 24 and 8.0 mu m at pH = 6.0 for A549 and HT-29, respectively). ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007). | en |
dc.publisher | Wiley-V C H Verlag Gmbh, Weinheim | |
dc.rights | restrictedAccess | |
dc.source | European Journal of Inorganic Chemistry | |
dc.subject | antitumour agents | en |
dc.subject | ruthenium | en |
dc.subject | N,S ligands | en |
dc.subject | X-ray diffraction | en |
dc.title | Ruthenium(II) complexes of thiosemicarbazones: The first Walter-soluble complex with pH-Dependent antiproliferative activity | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Aрион, Владимир Б.; Кепплер, Бернхард К.; Коwол, Цхристиан Р.; Роллер, Aлеxандер; Еицхингер, Рене; Валиахди, Сеиед-Мојтаба; Схова, Сергиу; Јакупец, Мицхаел A.; Гргурић-Шипка, Сања; | |
dc.citation.issue | 18 | |
dc.citation.spage | 2870 | |
dc.citation.epage | 2878 | |
dc.identifier.wos | 000247937300039 | |
dc.identifier.doi | 10.1002/ejic.200601196 | |
dc.citation.other | (18): 2870-2878 | |
dc.citation.rank | M21 | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-34447515399 |