Synthesis of novel polar derivatives of the antimalarial endoperoxides ascaridole and dihydroascaridole
Abstract
Novel polar derivatives of the antimalarial endoperoxide ascaridole were synthesized based on the zeolite NaY-promoted isomerization of perillyl and nopol derivatives to conjugated cyclohexadienes, followed by reaction with singlet oxygen. Several unsaturated endoperoxides were in situ reduced with diimide to form dihydroascaridole derivatives, as well.
Keywords:
isomerization / zeolites / singlet oxygen / endoperoxides / ascaridoleSource:
Arkivoc, 2007, 124-135Publisher:
- Arkat Usa Inc, Gainesville
Collections
Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Hatzakis, Emmanuel AU - Opsenica, Igor AU - Šolaja, Bogdan A. AU - Stratakis, Manolis PY - 2007 UR - https://cherry.chem.bg.ac.rs/handle/123456789/861 AB - Novel polar derivatives of the antimalarial endoperoxide ascaridole were synthesized based on the zeolite NaY-promoted isomerization of perillyl and nopol derivatives to conjugated cyclohexadienes, followed by reaction with singlet oxygen. Several unsaturated endoperoxides were in situ reduced with diimide to form dihydroascaridole derivatives, as well. PB - Arkat Usa Inc, Gainesville T2 - Arkivoc T1 - Synthesis of novel polar derivatives of the antimalarial endoperoxides ascaridole and dihydroascaridole SP - 124 EP - 135 UR - https://hdl.handle.net/21.15107/rcub_cherry_861 ER -
@article{ author = "Hatzakis, Emmanuel and Opsenica, Igor and Šolaja, Bogdan A. and Stratakis, Manolis", year = "2007", abstract = "Novel polar derivatives of the antimalarial endoperoxide ascaridole were synthesized based on the zeolite NaY-promoted isomerization of perillyl and nopol derivatives to conjugated cyclohexadienes, followed by reaction with singlet oxygen. Several unsaturated endoperoxides were in situ reduced with diimide to form dihydroascaridole derivatives, as well.", publisher = "Arkat Usa Inc, Gainesville", journal = "Arkivoc", title = "Synthesis of novel polar derivatives of the antimalarial endoperoxides ascaridole and dihydroascaridole", pages = "124-135", url = "https://hdl.handle.net/21.15107/rcub_cherry_861" }
Hatzakis, E., Opsenica, I., Šolaja, B. A.,& Stratakis, M.. (2007). Synthesis of novel polar derivatives of the antimalarial endoperoxides ascaridole and dihydroascaridole. in Arkivoc Arkat Usa Inc, Gainesville., 124-135. https://hdl.handle.net/21.15107/rcub_cherry_861
Hatzakis E, Opsenica I, Šolaja BA, Stratakis M. Synthesis of novel polar derivatives of the antimalarial endoperoxides ascaridole and dihydroascaridole. in Arkivoc. 2007;:124-135. https://hdl.handle.net/21.15107/rcub_cherry_861 .
Hatzakis, Emmanuel, Opsenica, Igor, Šolaja, Bogdan A., Stratakis, Manolis, "Synthesis of novel polar derivatives of the antimalarial endoperoxides ascaridole and dihydroascaridole" in Arkivoc (2007):124-135, https://hdl.handle.net/21.15107/rcub_cherry_861 .