Synthesis, characterization and biological activity evaluation of novel Pd(II) and Pt(II) complexes with heterocyclic hydrazone ligands
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Filipović, Nenad R.Todorović, Tamara
Sladić, Dušan
Novaković, Irena T.
Jeremić, Dejan
Anđelković, Katarina K.
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New complexes of Pt(II) with condensation derivatives of ethyl hydrazino acetate and either 2-acetylpyridine or 2-quinolinecarboxaldehyde, and of Pd(II) with the condensation derivative of ethyl hydrazinoacetate and 2-quinolinecarboxaldehyde were synthesized and characterized by elemental analysis, IR, H-1- and C-13-NMR spectroscopy, and molar conductivity measurements. The complexes have a square planar geometry, ligands binding as bidentates in the neutral form, and the remaining two coordination sites being occupied by chloride ions. Biological activity of new complexes, and of previously synthesized Pd(II), Cd(II), Co(III) and Zn(II) complexes with this ligand type was evaluated by the brine shrimp test. All the complexes showed a moderate activity.
Keywords:
2-acetylpyridine derivatives / 2-quinolinecarboxaldehyde derivatives / d-metal complexes / biological activitySource:
Materials Science Forum, 2007, 555, 423-427Publisher:
- Trans Tech Publications Ltd, Durnten-Zurich
Funding / projects:
- Interakcije prirodnih proizvoda i njihovih analoga sa proteinima i nukleinskim kiselinama (RS-MESTD-MPN2006-2010-142026)
DOI: 10.4028/www.scientific.net/MSF.555.423
ISSN: 0255-5476
WoS: 000249653700068
Scopus: 2-s2.0-38349028797
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Hemijski fakultet / Faculty of ChemistryTY - CONF AU - Filipović, Nenad R. AU - Todorović, Tamara AU - Sladić, Dušan AU - Novaković, Irena T. AU - Jeremić, Dejan AU - Anđelković, Katarina K. PY - 2007 UR - https://cherry.chem.bg.ac.rs/handle/123456789/866 AB - New complexes of Pt(II) with condensation derivatives of ethyl hydrazino acetate and either 2-acetylpyridine or 2-quinolinecarboxaldehyde, and of Pd(II) with the condensation derivative of ethyl hydrazinoacetate and 2-quinolinecarboxaldehyde were synthesized and characterized by elemental analysis, IR, H-1- and C-13-NMR spectroscopy, and molar conductivity measurements. The complexes have a square planar geometry, ligands binding as bidentates in the neutral form, and the remaining two coordination sites being occupied by chloride ions. Biological activity of new complexes, and of previously synthesized Pd(II), Cd(II), Co(III) and Zn(II) complexes with this ligand type was evaluated by the brine shrimp test. All the complexes showed a moderate activity. PB - Trans Tech Publications Ltd, Durnten-Zurich C3 - Materials Science Forum T1 - Synthesis, characterization and biological activity evaluation of novel Pd(II) and Pt(II) complexes with heterocyclic hydrazone ligands VL - 555 SP - 423 EP - 427 DO - 10.4028/www.scientific.net/MSF.555.423 ER -
@conference{ author = "Filipović, Nenad R. and Todorović, Tamara and Sladić, Dušan and Novaković, Irena T. and Jeremić, Dejan and Anđelković, Katarina K.", year = "2007", abstract = "New complexes of Pt(II) with condensation derivatives of ethyl hydrazino acetate and either 2-acetylpyridine or 2-quinolinecarboxaldehyde, and of Pd(II) with the condensation derivative of ethyl hydrazinoacetate and 2-quinolinecarboxaldehyde were synthesized and characterized by elemental analysis, IR, H-1- and C-13-NMR spectroscopy, and molar conductivity measurements. The complexes have a square planar geometry, ligands binding as bidentates in the neutral form, and the remaining two coordination sites being occupied by chloride ions. Biological activity of new complexes, and of previously synthesized Pd(II), Cd(II), Co(III) and Zn(II) complexes with this ligand type was evaluated by the brine shrimp test. All the complexes showed a moderate activity.", publisher = "Trans Tech Publications Ltd, Durnten-Zurich", journal = "Materials Science Forum", title = "Synthesis, characterization and biological activity evaluation of novel Pd(II) and Pt(II) complexes with heterocyclic hydrazone ligands", volume = "555", pages = "423-427", doi = "10.4028/www.scientific.net/MSF.555.423" }
Filipović, N. R., Todorović, T., Sladić, D., Novaković, I. T., Jeremić, D.,& Anđelković, K. K.. (2007). Synthesis, characterization and biological activity evaluation of novel Pd(II) and Pt(II) complexes with heterocyclic hydrazone ligands. in Materials Science Forum Trans Tech Publications Ltd, Durnten-Zurich., 555, 423-427. https://doi.org/10.4028/www.scientific.net/MSF.555.423
Filipović NR, Todorović T, Sladić D, Novaković IT, Jeremić D, Anđelković KK. Synthesis, characterization and biological activity evaluation of novel Pd(II) and Pt(II) complexes with heterocyclic hydrazone ligands. in Materials Science Forum. 2007;555:423-427. doi:10.4028/www.scientific.net/MSF.555.423 .
Filipović, Nenad R., Todorović, Tamara, Sladić, Dušan, Novaković, Irena T., Jeremić, Dejan, Anđelković, Katarina K., "Synthesis, characterization and biological activity evaluation of novel Pd(II) and Pt(II) complexes with heterocyclic hydrazone ligands" in Materials Science Forum, 555 (2007):423-427, https://doi.org/10.4028/www.scientific.net/MSF.555.423 . .