Docking studies suggest ligand-specific delta-opioid receptor conformations
Abstract
An automated docking procedure was used to study binding of a series of delta-selective ligands to three models of the delta-opioid receptor. These models are thought to represent the three ligand-specific receptor conformations. Docking results are in agreement with point mutation studies and suggest that different ligands-agonists and antagonists-may bind to the same binding site under different receptor conformations. Docking to different receptor models ( conformations) also suggests that by changing to a receptor-specific conformation, the receptor may open or close different binding sites to other ligands.
Keywords:
Delta opioid receptor / Docking simulation / Ligand-receptor interactions / Molecular modelingSource:
Journal of Molecular Modeling, 2009, 15, 3, 267-280Publisher:
- Springer, New York
Funding / projects:
- Ministry of Science and Environmental Protection of the Republic of Serbia
DOI: 10.1007/s00894-008-0396-7
ISSN: 1610-2940
PubMed: 19052783
WoS: 000262578200005
Scopus: 2-s2.0-59149102761
Collections
Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Micovic, Vuk AU - Ivanović, Milovan AU - Došen-Mićović, Ljiljana PY - 2009 UR - https://cherry.chem.bg.ac.rs/handle/123456789/872 AB - An automated docking procedure was used to study binding of a series of delta-selective ligands to three models of the delta-opioid receptor. These models are thought to represent the three ligand-specific receptor conformations. Docking results are in agreement with point mutation studies and suggest that different ligands-agonists and antagonists-may bind to the same binding site under different receptor conformations. Docking to different receptor models ( conformations) also suggests that by changing to a receptor-specific conformation, the receptor may open or close different binding sites to other ligands. PB - Springer, New York T2 - Journal of Molecular Modeling T1 - Docking studies suggest ligand-specific delta-opioid receptor conformations VL - 15 IS - 3 SP - 267 EP - 280 DO - 10.1007/s00894-008-0396-7 ER -
@article{ author = "Micovic, Vuk and Ivanović, Milovan and Došen-Mićović, Ljiljana", year = "2009", abstract = "An automated docking procedure was used to study binding of a series of delta-selective ligands to three models of the delta-opioid receptor. These models are thought to represent the three ligand-specific receptor conformations. Docking results are in agreement with point mutation studies and suggest that different ligands-agonists and antagonists-may bind to the same binding site under different receptor conformations. Docking to different receptor models ( conformations) also suggests that by changing to a receptor-specific conformation, the receptor may open or close different binding sites to other ligands.", publisher = "Springer, New York", journal = "Journal of Molecular Modeling", title = "Docking studies suggest ligand-specific delta-opioid receptor conformations", volume = "15", number = "3", pages = "267-280", doi = "10.1007/s00894-008-0396-7" }
Micovic, V., Ivanović, M.,& Došen-Mićović, L.. (2009). Docking studies suggest ligand-specific delta-opioid receptor conformations. in Journal of Molecular Modeling Springer, New York., 15(3), 267-280. https://doi.org/10.1007/s00894-008-0396-7
Micovic V, Ivanović M, Došen-Mićović L. Docking studies suggest ligand-specific delta-opioid receptor conformations. in Journal of Molecular Modeling. 2009;15(3):267-280. doi:10.1007/s00894-008-0396-7 .
Micovic, Vuk, Ivanović, Milovan, Došen-Mićović, Ljiljana, "Docking studies suggest ligand-specific delta-opioid receptor conformations" in Journal of Molecular Modeling, 15, no. 3 (2009):267-280, https://doi.org/10.1007/s00894-008-0396-7 . .