Two new phenylpiperazines with atypical antipsychotic potential
Authorized Users Only
Article (Published version)
MetadataShow full item record
Two new series of substituted arylpiperazines with heterocyclic 3-propoxy-benzimidazole or 3-propoxy-benzimidazole-2-thione groups were synthesized and their in vitro binding affinities for the D,, 5-HT1A, 5-HT2A, and alpha-adrenergic receptors determined. Among them, only two compounds with phenyl aryl-constituent (8a and 9a) showed 5-HT2A/D-2 pK(i) binding ratios proposed for atypical neuroleptics. As to their behavioral screening on rodents, both compounds exhibited a non-cataleptic action in rats and antagonized D-amphetamine-induced hyperlocomotion in mice, suggesting their possible atypical antipsychotic potency. (c) 2007 Elsevier Ltd. All rights reserved.
Keywords:arylpiperazines / dopamine receptors / serotonin receptors / atypical antipsychotics
Source:Bioorganic and Medicinal Chemistry Letters, 2007, 17, 21, 5749-5753
- Pergamon-Elsevier Science Ltd, Oxford