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Chemical modification of the lectin of the marine coral Gerardia savaglia by marine quinone avarone

Hemijske modifikacije lektina morskog korala Gerardia savaglia morskim hinonom avaronom

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2007
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Authors
Pajic, Ivana
Vujčić, Zoran
Vujčić, Miroslava
Novaković, Irena T.
Sladić, Dušan
Gasic, Miroslav J.
Article (Published version)
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Abstract
The quinone avarone, isolated from the marine sponge Dysidea avara, possesses the ability to chemically modify proteins. In this work, modification of lectin isolated from the coral Gerardia savaglia by avarone was examined. The techniques used for studying the modification were: SDS PAGE, isoelectric focusing and hemagglutination testing. The results of the SDS PAGE indicate dimerization of the protein. A shift of the pI toward lower value occurs upon modification. The change of the hemagglutination activity of the protein confirms that chemical modification of G. savaglia lectin by avarone changes its ability to interact with the membrane of erythrocytes.
Avaron, hinon izolovan iz morskog sunđera Dysidea avara, poseduje sposobnost da hemijski modifikuje proteine. U ovom radu ispitivana je modifikacija lektina izolovanog iz korala Gerardia savaglia avaronom. Tehnike za praćenje hemijske modifikacije bile su: SDS PAGE, izoelektrično fokusiranje i hemaglutinacioni test. Rezultati SDS PAGE upućuju na dimerizaciju proteina. Dolazi do pomeranja pI vrednosti proteina. Promena hemaglutinacione aktivnosti G. savaglia lektina avaronom uticala je na njegovu sposobnost interakcije sa membranom eritrocita.
Keywords:
avarone / quinone / quinone / Gerardia savaglia lectin / Gerardia savaglia lectin / covalent modification / covalent modification
Source:
Journal of the Serbian Chemical Society, 2007, 72, 12, 1271-1274
Publisher:
  • Serbian Chemical Soc, Belgrade
Funding / projects:
  • Interakcije prirodnih proizvoda i njihovih analoga sa proteinima i nukleinskim kiselinama (RS-142026)

DOI: 10.2298/JSC0712271P

ISSN: 0352-5139

WoS: 000252412100011

Scopus: 2-s2.0-36949025210
[ Google Scholar ]
1
1
URI
https://cherry.chem.bg.ac.rs/handle/123456789/906
Collections
  • Publikacije
Institution/Community
Hemijski fakultet
TY  - JOUR
AU  - Pajic, Ivana
AU  - Vujčić, Zoran
AU  - Vujčić, Miroslava
AU  - Novaković, Irena T.
AU  - Sladić, Dušan
AU  - Gasic, Miroslav J.
PY  - 2007
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/906
AB  - The quinone avarone, isolated from the marine sponge Dysidea avara, possesses the ability to chemically modify proteins. In this work, modification of lectin isolated from the coral Gerardia savaglia by avarone was examined. The techniques used for studying the modification were: SDS PAGE, isoelectric focusing and hemagglutination testing. The results of the SDS PAGE indicate dimerization of the protein. A shift of the pI toward lower value occurs upon modification. The change of the hemagglutination activity of the protein confirms that chemical modification of G. savaglia lectin by avarone changes its ability to interact with the membrane of erythrocytes.
AB  - Avaron, hinon izolovan iz morskog sunđera Dysidea avara, poseduje sposobnost da hemijski modifikuje proteine. U ovom radu ispitivana je modifikacija lektina izolovanog iz korala Gerardia savaglia avaronom. Tehnike za praćenje hemijske modifikacije bile su: SDS PAGE, izoelektrično fokusiranje i hemaglutinacioni test. Rezultati SDS PAGE upućuju na dimerizaciju proteina. Dolazi do pomeranja pI vrednosti proteina. Promena hemaglutinacione aktivnosti G. savaglia lektina avaronom uticala je na njegovu sposobnost interakcije sa membranom eritrocita.
PB  - Serbian Chemical Soc, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - Chemical modification of the lectin of the marine coral Gerardia savaglia by marine quinone avarone
T1  - Hemijske modifikacije lektina morskog korala Gerardia savaglia morskim hinonom avaronom
VL  - 72
IS  - 12
SP  - 1271
EP  - 1274
DO  - 10.2298/JSC0712271P
UR  - Kon_1859
ER  - 
@article{
author = "Pajic, Ivana and Vujčić, Zoran and Vujčić, Miroslava and Novaković, Irena T. and Sladić, Dušan and Gasic, Miroslav J.",
year = "2007",
abstract = "The quinone avarone, isolated from the marine sponge Dysidea avara, possesses the ability to chemically modify proteins. In this work, modification of lectin isolated from the coral Gerardia savaglia by avarone was examined. The techniques used for studying the modification were: SDS PAGE, isoelectric focusing and hemagglutination testing. The results of the SDS PAGE indicate dimerization of the protein. A shift of the pI toward lower value occurs upon modification. The change of the hemagglutination activity of the protein confirms that chemical modification of G. savaglia lectin by avarone changes its ability to interact with the membrane of erythrocytes., Avaron, hinon izolovan iz morskog sunđera Dysidea avara, poseduje sposobnost da hemijski modifikuje proteine. U ovom radu ispitivana je modifikacija lektina izolovanog iz korala Gerardia savaglia avaronom. Tehnike za praćenje hemijske modifikacije bile su: SDS PAGE, izoelektrično fokusiranje i hemaglutinacioni test. Rezultati SDS PAGE upućuju na dimerizaciju proteina. Dolazi do pomeranja pI vrednosti proteina. Promena hemaglutinacione aktivnosti G. savaglia lektina avaronom uticala je na njegovu sposobnost interakcije sa membranom eritrocita.",
publisher = "Serbian Chemical Soc, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "Chemical modification of the lectin of the marine coral Gerardia savaglia by marine quinone avarone, Hemijske modifikacije lektina morskog korala Gerardia savaglia morskim hinonom avaronom",
volume = "72",
number = "12",
pages = "1271-1274",
doi = "10.2298/JSC0712271P",
url = "Kon_1859"
}
Pajic, I., Vujčić, Z., Vujčić, M., Novaković, I. T., Sladić, D.,& Gasic, M. J.. (2007). Chemical modification of the lectin of the marine coral Gerardia savaglia by marine quinone avarone. in Journal of the Serbian Chemical Society
Serbian Chemical Soc, Belgrade., 72(12), 1271-1274.
https://doi.org/10.2298/JSC0712271P
Kon_1859
Pajic I, Vujčić Z, Vujčić M, Novaković IT, Sladić D, Gasic MJ. Chemical modification of the lectin of the marine coral Gerardia savaglia by marine quinone avarone. in Journal of the Serbian Chemical Society. 2007;72(12):1271-1274.
doi:10.2298/JSC0712271P
Kon_1859 .
Pajic, Ivana, Vujčić, Zoran, Vujčić, Miroslava, Novaković, Irena T., Sladić, Dušan, Gasic, Miroslav J., "Chemical modification of the lectin of the marine coral Gerardia savaglia by marine quinone avarone" in Journal of the Serbian Chemical Society, 72, no. 12 (2007):1271-1274,
https://doi.org/10.2298/JSC0712271P .,
Kon_1859 .

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