High-yield synthesis of substituted and unsubstituted pyridinium salts containing a 4-oxothiazolidine moiety

Abstract

A new series of unsubstituted and substituted pyridinium salts bearing a 4-oxothiazolidinyl moiety has been prepared by an efficient rearrangement of 2-(I-bromoalkylidene)thiazolidin-4ones. The process is based on three steps, namely carbon-bromine cleavage, bromine transfer, and substitution, each induced by pyridine or its derivatives, acting as base and reactant.