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Mixed tetraoxanes containing the acetone subunit as antimalarials
dc.creator | Opsenica, Dejan M. | |
dc.creator | Terzić-Jovanović, Nataša | |
dc.creator | Smith, Philip L. | |
dc.creator | Yang, Youngsun | |
dc.creator | Anova, Lalaine | |
dc.creator | Smith, Kirsten S. | |
dc.creator | Šolaja, Bogdan A. | |
dc.date.accessioned | 2018-11-22T00:13:22Z | |
dc.date.available | 2018-11-22T00:13:22Z | |
dc.date.issued | 2008 | |
dc.identifier.issn | 0968-0896 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/957 | |
dc.description.abstract | Eleven new tetraoxanes possessing cholic acid-derived carrier and isopropylidene moiety were synthesized and were tested in vitro and in vivo. In vitro screening revealed that nine of them were more potent against CQ-resistant W2 than CQ-susceptible D6 strain and that two of them were equally or more potent than artemisinin and mefloquine against multi- drug resistant TM91C235 strain. Amine 8 cured all mice at the dose of 160 mg/kg/day, while the anilide 9 exhibited MCD lt = 20 mg/kg/day. The diol 13 was most potent antiproliferative with GI(50), TGI, LC50 MG_MID 0.98 mu M, 3.80 mu M, 11.22 mu M, respectively. All tested compounds showed no toxic effects. (c) 2008 Elsevier Ltd. All rights reserved. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.rights | restrictedAccess | |
dc.source | Bioorganic and Medicinal Chemistry | |
dc.subject | mixed steroidal tetraoxanes | en |
dc.subject | cholic acid | en |
dc.subject | antimalarials | en |
dc.subject | antiproliferatives | en |
dc.subject | metabolic stability | en |
dc.title | Mixed tetraoxanes containing the acetone subunit as antimalarials | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Опсеница, Дејан М.; Aнова, Лалаине; Смитх, Кирстен С.; Смитх, Пхилип Л.; Терзиц, Натаса; Yанг, Yоунгсун; Шолаја, Богдан A.; | |
dc.citation.volume | 16 | |
dc.citation.issue | 14 | |
dc.citation.spage | 7039 | |
dc.citation.epage | 7045 | |
dc.identifier.wos | 000257829600042 | |
dc.identifier.doi | 10.1016/j.bmc.2008.05.017 | |
dc.citation.other | 16(14): 7039-7045 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 18550377 | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-48949115566 |
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