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dc.creatorJovanović, Vesna B.
dc.creatorDimitrijevic-Sreckovic, V. S.
dc.creatorMandić, Ljuba M.
dc.date.accessioned2018-11-22T00:13:23Z
dc.date.available2018-11-22T00:13:23Z
dc.date.issued2008
dc.identifier.issn0887-8013
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/958
dc.description.abstractThe connection between changes in the activity of serum N-acetyl-beta-D-glucosaminidase (NAG, E.C.3.2.1.30) and iso-enzymes and degree of secondary complications was analyzed in four groups of type 1 diabetic patients (n=69): without complications (n=22); with retinopathy (n=16); with retinopathy and polyneuropathy (n= 13), and with retinopathy, neuropathy, and nephropathy (n=18). In all groups statistically significant higher (P lt 0.001) percent fraction of A form (83.84 +/- 6.09, 84.37 +/- 5.74, 81.76 +/- 6.02, 76.37 +/- 7.38%, resp.) and lower (P lt 0.001, P lt 0.01) fraction of B form (15.87 +/- 5.65, 15.66 +/- 5.74, 18.33 +/- 5.98, 23.63 +/- 7.38, resp.) in total NAG compared with the control (A = 69.38 +/- 4.79%, B = 30.61 +/- 4.78%) were found. The differences in A as well as B forms between diabetic groups were not statistically significant. Significant strong positive correlations between total NAG and glycemia (0.494-0.623), total NAG and A form (0.934-0.966), and A form and glycemia (0.512-0.638) were found in all groups. No correlation was found between the fractions of B and A forms, except in the fourth group. The A form of diabetic patients in the fourth group was more acidic compared with the control and other diabetic groups. It was concluded that the changes in serum NAG and isoenzymic profiles in diabetes are the consequence of its increased exocytose, especially of the A form, in hyperglycemia and posttranslational modifications of iso-enzymes. The total activity of serum NAG and iso-enzymic profiles cannot be used for monitoring the development and distinction of type 1 diabetes secondary complications.en
dc.publisherWiley-Liss, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142020/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Clinical Laboratory Analysis
dc.subjectserum N-acetyl-beta-D-glucosaminidaseen
dc.subjectiso-enzymes A and Ben
dc.subjecttype 1 diabetesen
dc.subjectdiabetic complicationsen
dc.subjectretinopathyen
dc.subjectneuropathyen
dc.subjectnephropathyen
dc.titleSerum N-acetyl-beta-D-glucosaminidase profiles in type 1 diabetes secondary complications: Causes of changes and significance of determinationen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМандић, Љуба М.; Јовановић, Весна; Димитријевиц-Срецковиц, В. С.;
dc.citation.volume22
dc.citation.issue4
dc.citation.spage307
dc.citation.epage313
dc.identifier.wos000257900400015
dc.identifier.doi10.1002/jcla.20262
dc.citation.other22(4): 307-313
dc.citation.rankM23
dc.identifier.pmid18623113
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-48249093430
dc.identifier.rcubKon_1911


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