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dc.creatorŠolaja, Bogdan A.
dc.creatorOpsenica, Dejan M.
dc.creatorSmith, Kirsten S.
dc.creatorMilhous, Wilbur K.
dc.creatorTerzić-Jovanović, Nataša
dc.creatorOpsenica, Igor
dc.creatorBurnett, James C.
dc.creatorNuss, Jon
dc.creatorGussio, Rick
dc.creatorBavari, Sina
dc.date.accessioned2018-11-22T00:13:26Z
dc.date.available2018-11-22T00:13:26Z
dc.date.issued2008
dc.identifier.issn0022-2623
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/961
dc.description.abstractWe report on the initial result of the coupling of 4-amino7-chloroquinoline with steroidal and adamantane constituents to provide small molecules with excellent in vitro antimalarial activities (IC90 (W2) down to 6.74 nM). The same entities also inhibit the botulinum neurotoxin serotype A light chain metalloprotease at low nlicromolar levels (7-3 1 yM). Interestingly. structural features imparting increased antimalarial activity also provide increased inetalloprotease inhibition, thus allowing for simultaneous compound optimizations against distinct targets.en
dc.publisherAmer Chemical Soc, Washington
dc.relationNCI NIH HHS [Y3-CM-100505]
dc.rightsrestrictedAccess
dc.sourceJournal of Medicinal Chemistry
dc.titleNovel 4-aminoquinolines active against chloroquine-resistant and sensitive P. falciparum strains that also inhibit botulinum serotype Aen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМилхоус, Wилбур К.; Смитх, Кирстен С.; Опсеница, Игор; Нусс, Јон; Гуссио, Рицк; Бурнетт, Јамес Ц.; Бавари, Сина; Терзиц, Натаса; Шолаја, Богдан A.; Опсеница, Дејан;
dc.citation.volume51
dc.citation.issue15
dc.citation.spage4388
dc.citation.epage4391
dc.identifier.wos000258289800007
dc.identifier.doi10.1021/jm800737y
dc.citation.other51(15): 4388-4391
dc.citation.rankaM21
dc.identifier.pmid18637666
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-49449118829
dc.identifier.rcubKon_1914


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