Приказ основних података о документу

dc.creatorAndrić, Deana
dc.creatorRoglić, Goran
dc.creatorŠukalović, Vladimir
dc.creatorŠoškić, Vukić
dc.creatorKostić-Rajačić, Slađana
dc.date.accessioned2018-11-22T00:13:34Z
dc.date.available2018-11-22T00:13:34Z
dc.date.issued2008
dc.identifier.issn0223-5234
dc.identifier.urihttps://cherry.chem.bg.ac.rs/handle/123456789/969
dc.description.abstractIn this publication we are describing synthesis, binding properties, and receptor docking of 4-halo-6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles, a new compounds with potential antipsychotics properties. Affinity towards the dopamine D(1)-like and D(2)-like, and serotonin 5-HT(1A) receptors was evaluated using the radioligand binding assays. All compounds tested had affinity for the D(2)-like and 5-HT(1A) receptors, but were inactive towards the D(1)-like receptor. Halogenated 6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles showed higher affinity compared to their nonhalogenated congeners. In silico docking analysis of selected ligands was performed in order to explain the results of binding assays. Our analysis suggests that stabilizing interactions between the halogen atom at the benzimidazole ring and the Ser-122 of the D(2)-like and Trp-358 of the 5-HT(1A) receptor. Energy contributions for these interactions were calculated using the ab initio method. (c) 2007 Elsevier Masson SAS. All rights reserved.en
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier, Paris
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142009/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Medicinal Chemistry
dc.subjectdopamine receptoren
dc.subjectserotonin receptoren
dc.subjectrational drug designen
dc.titleSynthesis, binding properties and receptor docking of 4-halo-6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles, mixed ligands of D(2) and 5-HT(1A) receptorsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСоскиц, Вукиц; Сукаловиц, Владимир; Костиц-Рајациц, Сладјана; Роглић, Горан; Aндрић, Деана;
dc.citation.volume43
dc.citation.issue8
dc.citation.spage1696
dc.citation.epage1705
dc.identifier.wos000259161600014
dc.identifier.doi10.1016/j.ejmech.2007.09.027
dc.citation.other43(8): 1696-1705
dc.citation.rankM22
dc.identifier.pmid18006194
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-48049117780


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Приказ основних података о документу