The synthesis and biological evaluation of 3β-hydroxylanosta-7,9-dien-32-al
Apstrakt
The synthesis of the title compound a key intermediate for the synthesis of other DHL derivatives, is reported. The aldehyde 1 and the diol 9 were tested on several enzymes involved in the cholesterol biosynthetic pathway. Aldehyde 1 showed an inhibitory effect IC50 = 90 μM on sterol 14-reductase.
Ključne reči:
Dihydrolanosterol Δ7,9 derivatives / Enzyme inhibitory effect of / SynthesisIzvor:
Journal of the Serbian Chemical Society, 1996, 61, 11, 1113-1116Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Šolaja, Bogdan A. AU - Djermanović, M. AU - Lim, D.M. AU - Paik, Y.-K. PY - 1996 UR - https://cherry.chem.bg.ac.rs/handle/123456789/97 AB - The synthesis of the title compound a key intermediate for the synthesis of other DHL derivatives, is reported. The aldehyde 1 and the diol 9 were tested on several enzymes involved in the cholesterol biosynthetic pathway. Aldehyde 1 showed an inhibitory effect IC50 = 90 μM on sterol 14-reductase. T2 - Journal of the Serbian Chemical Society T1 - The synthesis and biological evaluation of 3β-hydroxylanosta-7,9-dien-32-al VL - 61 IS - 11 SP - 1113 EP - 1116 UR - https://hdl.handle.net/21.15107/rcub_cherry_97 ER -
@article{ author = "Šolaja, Bogdan A. and Djermanović, M. and Lim, D.M. and Paik, Y.-K.", year = "1996", abstract = "The synthesis of the title compound a key intermediate for the synthesis of other DHL derivatives, is reported. The aldehyde 1 and the diol 9 were tested on several enzymes involved in the cholesterol biosynthetic pathway. Aldehyde 1 showed an inhibitory effect IC50 = 90 μM on sterol 14-reductase.", journal = "Journal of the Serbian Chemical Society", title = "The synthesis and biological evaluation of 3β-hydroxylanosta-7,9-dien-32-al", volume = "61", number = "11", pages = "1113-1116", url = "https://hdl.handle.net/21.15107/rcub_cherry_97" }
Šolaja, B. A., Djermanović, M., Lim, D.M.,& Paik, Y.-K.. (1996). The synthesis and biological evaluation of 3β-hydroxylanosta-7,9-dien-32-al. in Journal of the Serbian Chemical Society, 61(11), 1113-1116. https://hdl.handle.net/21.15107/rcub_cherry_97
Šolaja BA, Djermanović M, Lim D, Paik Y. The synthesis and biological evaluation of 3β-hydroxylanosta-7,9-dien-32-al. in Journal of the Serbian Chemical Society. 1996;61(11):1113-1116. https://hdl.handle.net/21.15107/rcub_cherry_97 .
Šolaja, Bogdan A., Djermanović, M., Lim, D.M., Paik, Y.-K., "The synthesis and biological evaluation of 3β-hydroxylanosta-7,9-dien-32-al" in Journal of the Serbian Chemical Society, 61, no. 11 (1996):1113-1116, https://hdl.handle.net/21.15107/rcub_cherry_97 .