Synthesis, characterization and antitumor activity of novel N-substituted alpha-amino acids containing ferrocenyl pyrazole-moiety
Само за регистроване кориснике
2009
Аутори
Joksović, Milan D.Marković, Violeta
Juranić, Zorica D.
Stanojković, Tatjana
Jovanović, Ljiljana S.
Damljanovic, Ivan S.
Szecsenyi, Katalin Meszaros
Todorović, Nina
Trifunović, Snežana S.
Vukicevic, Rastko D.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A series of new N-[(3-ferrocenyl-1-phenylpyrazol-4-yl)methyl] alpha-amino acids were prepared and characterized by a range of spectroscopic techniques and cyclic voltammetry. The in vitro antitumor activity of all synthesized compounds was investigated against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines using the MTT method. Tryptophan derivative 11 exhibited the highest cytotoxic activity in the cell growth inhibition of all three types of cell lines. (C) 2009 Elsevier B.V. All rights reserved.
Кључне речи:
Ferrocenyl pyrazole / Amino acids / CytotoxicityИзвор:
Journal of Organometallic Chemistry, 2009, 694, 24, 3935-3942Издавач:
- Elsevier Science Sa, Lausanne
Финансирање / пројекти:
- Развој нових електрохемијских и хемијских метода органске синтезе (RS-MESTD-MPN2006-2010-142042)
- Истраживање дејстава модификатора биолошког одговора у физиолошким и патолошким стањима (RS-MESTD-MPN2006-2010-145006)
- Синтезе, физичке, структурне и биолошке карактеристике нових комплексних једењења (RS-MESTD-MPN2006-2010-142028)
DOI: 10.1016/j.jorganchem.2009.08.013
ISSN: 0022-328X
WoS: 000271099300015
Scopus: 2-s2.0-70349999659
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Joksović, Milan D. AU - Marković, Violeta AU - Juranić, Zorica D. AU - Stanojković, Tatjana AU - Jovanović, Ljiljana S. AU - Damljanovic, Ivan S. AU - Szecsenyi, Katalin Meszaros AU - Todorović, Nina AU - Trifunović, Snežana S. AU - Vukicevic, Rastko D. PY - 2009 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1024 AB - A series of new N-[(3-ferrocenyl-1-phenylpyrazol-4-yl)methyl] alpha-amino acids were prepared and characterized by a range of spectroscopic techniques and cyclic voltammetry. The in vitro antitumor activity of all synthesized compounds was investigated against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines using the MTT method. Tryptophan derivative 11 exhibited the highest cytotoxic activity in the cell growth inhibition of all three types of cell lines. (C) 2009 Elsevier B.V. All rights reserved. PB - Elsevier Science Sa, Lausanne T2 - Journal of Organometallic Chemistry T1 - Synthesis, characterization and antitumor activity of novel N-substituted alpha-amino acids containing ferrocenyl pyrazole-moiety VL - 694 IS - 24 SP - 3935 EP - 3942 DO - 10.1016/j.jorganchem.2009.08.013 ER -
@article{ author = "Joksović, Milan D. and Marković, Violeta and Juranić, Zorica D. and Stanojković, Tatjana and Jovanović, Ljiljana S. and Damljanovic, Ivan S. and Szecsenyi, Katalin Meszaros and Todorović, Nina and Trifunović, Snežana S. and Vukicevic, Rastko D.", year = "2009", abstract = "A series of new N-[(3-ferrocenyl-1-phenylpyrazol-4-yl)methyl] alpha-amino acids were prepared and characterized by a range of spectroscopic techniques and cyclic voltammetry. The in vitro antitumor activity of all synthesized compounds was investigated against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines using the MTT method. Tryptophan derivative 11 exhibited the highest cytotoxic activity in the cell growth inhibition of all three types of cell lines. (C) 2009 Elsevier B.V. All rights reserved.", publisher = "Elsevier Science Sa, Lausanne", journal = "Journal of Organometallic Chemistry", title = "Synthesis, characterization and antitumor activity of novel N-substituted alpha-amino acids containing ferrocenyl pyrazole-moiety", volume = "694", number = "24", pages = "3935-3942", doi = "10.1016/j.jorganchem.2009.08.013" }
Joksović, M. D., Marković, V., Juranić, Z. D., Stanojković, T., Jovanović, L. S., Damljanovic, I. S., Szecsenyi, K. M., Todorović, N., Trifunović, S. S.,& Vukicevic, R. D.. (2009). Synthesis, characterization and antitumor activity of novel N-substituted alpha-amino acids containing ferrocenyl pyrazole-moiety. in Journal of Organometallic Chemistry Elsevier Science Sa, Lausanne., 694(24), 3935-3942. https://doi.org/10.1016/j.jorganchem.2009.08.013
Joksović MD, Marković V, Juranić ZD, Stanojković T, Jovanović LS, Damljanovic IS, Szecsenyi KM, Todorović N, Trifunović SS, Vukicevic RD. Synthesis, characterization and antitumor activity of novel N-substituted alpha-amino acids containing ferrocenyl pyrazole-moiety. in Journal of Organometallic Chemistry. 2009;694(24):3935-3942. doi:10.1016/j.jorganchem.2009.08.013 .
Joksović, Milan D., Marković, Violeta, Juranić, Zorica D., Stanojković, Tatjana, Jovanović, Ljiljana S., Damljanovic, Ivan S., Szecsenyi, Katalin Meszaros, Todorović, Nina, Trifunović, Snežana S., Vukicevic, Rastko D., "Synthesis, characterization and antitumor activity of novel N-substituted alpha-amino acids containing ferrocenyl pyrazole-moiety" in Journal of Organometallic Chemistry, 694, no. 24 (2009):3935-3942, https://doi.org/10.1016/j.jorganchem.2009.08.013 . .