A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA
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2010
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A new prenylated flavanonol named seselinonol (1) was isolated from the roots of Seseli annuum, together with the well-known biologically active polyacetylenes falcarinol (2) and falcarindiol (3), and the prenylated furanocoumarin phellopterin (4). Its structure was elucidated by extensive spectroscopic analysis, including HR-ESI-MS, ID- and 2D-NMR. Seselinonol and phellopterin were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The new compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.
Izvor:
Chemistry and Biodiversity, 2010, 7, 3, 698-704Izdavač:
- Wiley-V C H Verlag Gmbh, Weinheim
Finansiranje / projekti:
- Sekundarni metaboliti samoniklih, lekovitih biljaka: izolovanje, karakterizacija i biloška aktivnost (RS-142053)
DOI: 10.1002/cbdv.200900067
ISSN: 1612-1872
PubMed: 20232332
WoS: 000276059600015
Scopus: 2-s2.0-77949728574
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Vučković, Ivan M. AU - Vajs, Vlatka AU - Stanković, Miroslava AU - Tešević, Vele AU - Milosavljević, Slobodan M. PY - 2010 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1067 AB - A new prenylated flavanonol named seselinonol (1) was isolated from the roots of Seseli annuum, together with the well-known biologically active polyacetylenes falcarinol (2) and falcarindiol (3), and the prenylated furanocoumarin phellopterin (4). Its structure was elucidated by extensive spectroscopic analysis, including HR-ESI-MS, ID- and 2D-NMR. Seselinonol and phellopterin were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The new compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes. PB - Wiley-V C H Verlag Gmbh, Weinheim T2 - Chemistry and Biodiversity T1 - A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA VL - 7 IS - 3 SP - 698 EP - 704 DO - 10.1002/cbdv.200900067 ER -
@article{ author = "Vučković, Ivan M. and Vajs, Vlatka and Stanković, Miroslava and Tešević, Vele and Milosavljević, Slobodan M.", year = "2010", abstract = "A new prenylated flavanonol named seselinonol (1) was isolated from the roots of Seseli annuum, together with the well-known biologically active polyacetylenes falcarinol (2) and falcarindiol (3), and the prenylated furanocoumarin phellopterin (4). Its structure was elucidated by extensive spectroscopic analysis, including HR-ESI-MS, ID- and 2D-NMR. Seselinonol and phellopterin were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The new compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.", publisher = "Wiley-V C H Verlag Gmbh, Weinheim", journal = "Chemistry and Biodiversity", title = "A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA", volume = "7", number = "3", pages = "698-704", doi = "10.1002/cbdv.200900067" }
Vučković, I. M., Vajs, V., Stanković, M., Tešević, V.,& Milosavljević, S. M.. (2010). A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA. in Chemistry and Biodiversity Wiley-V C H Verlag Gmbh, Weinheim., 7(3), 698-704. https://doi.org/10.1002/cbdv.200900067
Vučković IM, Vajs V, Stanković M, Tešević V, Milosavljević SM. A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA. in Chemistry and Biodiversity. 2010;7(3):698-704. doi:10.1002/cbdv.200900067 .
Vučković, Ivan M., Vajs, Vlatka, Stanković, Miroslava, Tešević, Vele, Milosavljević, Slobodan M., "A New Prenylated Flavanonol from Seseli annuum Roots Showing Protective Effect on Human Lymphocytes DNA" in Chemistry and Biodiversity, 7, no. 3 (2010):698-704, https://doi.org/10.1002/cbdv.200900067 . .