Stereospecific ligands and their complexes. IV: Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with ethylenediamine-N,N '-di-S,S-2-propanoate and halogenido ligands: Crystal structure of s-cis-[Pt(S,S-eddp)Cl-2]center dot 4H(
Samo za registrovane korisnike
2010
Autori
Djinovic, Vesna M.Glodjovic, Verica V.
Vasic, Gordana P.
Trajković, Vladimir S.
Klisurić, Olivera
Stanković, Slobodanka
Sabo, Tibor
Trifunović, Srećko R.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The syntheses of two novel platinum(IV) complexes of formula [PtX2(S,S-eddp)center dot nH(2)O (S,S-eddp = ethylenediamine-N,N'-di-S,S-2-propanoate ion, X = chlorido (1) or bromido (2), n = 4, 0) are reported. The complexes have been obtained by direct reaction of corresponding potassium hexahalogenidoplatinate(IV) with neutralized ethylenediamine-N,N'-di-S,S-2-propanoic acid (H-2-S,S-eddp). The complexes were characterized by elemental analysis, infrared, H-1 and C-13 NMR spectroscopy. The spectroscopically predicted geometrical configurations of the obtained complexes were confirmed by X-ray analyses of the crystal structures of the s-cis-[Pt(S,S-eddp)Cl-2]center dot 4H(2)O and uns-cis-[Pt(S,S-eddp)Br-2]. These complexes displayed significantly lower in vitro cytotoxicity in comparison to cisplatin. (c) 2010 Elsevier Ltd. All rights reserved.
Ključne reči:
Platinum / Cytotoxicity / X-ray diffractionIzvor:
Polyhedron, 2010, 29, 8, 1933-1938Izdavač:
- Pergamon-Elsevier Science Ltd, Oxford
Finansiranje / projekti:
- Struktura novih kompleksa jona prelaznih metala i mehanizam njihovih reakcija sa biološki značajnim ligandima (RS-MESTD-MPN2006-2010-142008)
- Sinteza, karakterizacija i aktivnost organskih i koordinacionih jedinjenja i njihova primena u (bio)nanotehnologiji (RS-MESTD-MPN2006-2010-142010)
- Sinteza i fizičko-hemijska ispitivanja odabranih organskih jedinjenja od potencijalnog farmakološkog značaja (RS-MESTD-MPN2006-2010-142052)
- Citotoksični, citoprotektivni i imunomodulatorni efekti nanočestica (RS-MESTD-MPN2006-2010-145073)
DOI: 10.1016/j.poly.2010.03.004
ISSN: 0277-5387
WoS: 000278611800007
Scopus: 2-s2.0-77953231926
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Djinovic, Vesna M. AU - Glodjovic, Verica V. AU - Vasic, Gordana P. AU - Trajković, Vladimir S. AU - Klisurić, Olivera AU - Stanković, Slobodanka AU - Sabo, Tibor AU - Trifunović, Srećko R. PY - 2010 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1084 AB - The syntheses of two novel platinum(IV) complexes of formula [PtX2(S,S-eddp)center dot nH(2)O (S,S-eddp = ethylenediamine-N,N'-di-S,S-2-propanoate ion, X = chlorido (1) or bromido (2), n = 4, 0) are reported. The complexes have been obtained by direct reaction of corresponding potassium hexahalogenidoplatinate(IV) with neutralized ethylenediamine-N,N'-di-S,S-2-propanoic acid (H-2-S,S-eddp). The complexes were characterized by elemental analysis, infrared, H-1 and C-13 NMR spectroscopy. The spectroscopically predicted geometrical configurations of the obtained complexes were confirmed by X-ray analyses of the crystal structures of the s-cis-[Pt(S,S-eddp)Cl-2]center dot 4H(2)O and uns-cis-[Pt(S,S-eddp)Br-2]. These complexes displayed significantly lower in vitro cytotoxicity in comparison to cisplatin. (c) 2010 Elsevier Ltd. All rights reserved. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Polyhedron T1 - Stereospecific ligands and their complexes. IV: Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with ethylenediamine-N,N '-di-S,S-2-propanoate and halogenido ligands: Crystal structure of s-cis-[Pt(S,S-eddp)Cl-2]center dot 4H( VL - 29 IS - 8 SP - 1933 EP - 1938 DO - 10.1016/j.poly.2010.03.004 ER -
@article{ author = "Djinovic, Vesna M. and Glodjovic, Verica V. and Vasic, Gordana P. and Trajković, Vladimir S. and Klisurić, Olivera and Stanković, Slobodanka and Sabo, Tibor and Trifunović, Srećko R.", year = "2010", abstract = "The syntheses of two novel platinum(IV) complexes of formula [PtX2(S,S-eddp)center dot nH(2)O (S,S-eddp = ethylenediamine-N,N'-di-S,S-2-propanoate ion, X = chlorido (1) or bromido (2), n = 4, 0) are reported. The complexes have been obtained by direct reaction of corresponding potassium hexahalogenidoplatinate(IV) with neutralized ethylenediamine-N,N'-di-S,S-2-propanoic acid (H-2-S,S-eddp). The complexes were characterized by elemental analysis, infrared, H-1 and C-13 NMR spectroscopy. The spectroscopically predicted geometrical configurations of the obtained complexes were confirmed by X-ray analyses of the crystal structures of the s-cis-[Pt(S,S-eddp)Cl-2]center dot 4H(2)O and uns-cis-[Pt(S,S-eddp)Br-2]. These complexes displayed significantly lower in vitro cytotoxicity in comparison to cisplatin. (c) 2010 Elsevier Ltd. All rights reserved.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Polyhedron", title = "Stereospecific ligands and their complexes. IV: Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with ethylenediamine-N,N '-di-S,S-2-propanoate and halogenido ligands: Crystal structure of s-cis-[Pt(S,S-eddp)Cl-2]center dot 4H(", volume = "29", number = "8", pages = "1933-1938", doi = "10.1016/j.poly.2010.03.004" }
Djinovic, V. M., Glodjovic, V. V., Vasic, G. P., Trajković, V. S., Klisurić, O., Stanković, S., Sabo, T.,& Trifunović, S. R.. (2010). Stereospecific ligands and their complexes. IV: Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with ethylenediamine-N,N '-di-S,S-2-propanoate and halogenido ligands: Crystal structure of s-cis-[Pt(S,S-eddp)Cl-2]center dot 4H(. in Polyhedron Pergamon-Elsevier Science Ltd, Oxford., 29(8), 1933-1938. https://doi.org/10.1016/j.poly.2010.03.004
Djinovic VM, Glodjovic VV, Vasic GP, Trajković VS, Klisurić O, Stanković S, Sabo T, Trifunović SR. Stereospecific ligands and their complexes. IV: Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with ethylenediamine-N,N '-di-S,S-2-propanoate and halogenido ligands: Crystal structure of s-cis-[Pt(S,S-eddp)Cl-2]center dot 4H(. in Polyhedron. 2010;29(8):1933-1938. doi:10.1016/j.poly.2010.03.004 .
Djinovic, Vesna M., Glodjovic, Verica V., Vasic, Gordana P., Trajković, Vladimir S., Klisurić, Olivera, Stanković, Slobodanka, Sabo, Tibor, Trifunović, Srećko R., "Stereospecific ligands and their complexes. IV: Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with ethylenediamine-N,N '-di-S,S-2-propanoate and halogenido ligands: Crystal structure of s-cis-[Pt(S,S-eddp)Cl-2]center dot 4H(" in Polyhedron, 29, no. 8 (2010):1933-1938, https://doi.org/10.1016/j.poly.2010.03.004 . .