Synthesis, Cytotoxic Activity, and Thermal Studies of Novel N-[(1,3-Diphenylpyrazol-4-yl)methyl] alpha-Amino Acids
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2010
Authors
Joksović, Milan D.Bogdanović, Gordana
Kojić, Vesna
Szecsenyi, Katalin Meszaros
Leovac, Vukadin M.
Jakimov, Dimitar
Trifunović, Snežana S.
Marković, Violeta
Joksović, Ljubinka
Article (Published version)
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Show full item recordAbstract
New N-[(1,3-diphenylpyrazol-4-yl)methyl]alpha-amino acids (1a-i) have been synthesized and tested in vitro for their antiproliferative activity against human myelogenous leukemia K562, colon adenocarcinoma HT-29, cervix carcinoma HeLa, and normal fetal lung fibroblasts, MRC-5. Compounds derived from both phenylalanine enantiomer precursors appeared to be the most active against myelogenous leukemia K562 cell lines with a high cytotoxic potential.
Source:
Journal of Heterocyclic Chemistry, 2010, 47, 4, 850-856Publisher:
- Wiley-Blackwell, Malden
Funding / projects:
- Sinteze, fizičke, strukturne i biološke karakteristike novih kompleksnih jedenjenja (RS-142028)
- Provincial Secretariat for Science and Technological Development of Vojvodina
DOI: 10.1002/jhet.400
ISSN: 0022-152X
WoS: 000280450700010
Scopus: 2-s2.0-77954598700
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Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Joksović, Milan D. AU - Bogdanović, Gordana AU - Kojić, Vesna AU - Szecsenyi, Katalin Meszaros AU - Leovac, Vukadin M. AU - Jakimov, Dimitar AU - Trifunović, Snežana S. AU - Marković, Violeta AU - Joksović, Ljubinka PY - 2010 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1097 AB - New N-[(1,3-diphenylpyrazol-4-yl)methyl]alpha-amino acids (1a-i) have been synthesized and tested in vitro for their antiproliferative activity against human myelogenous leukemia K562, colon adenocarcinoma HT-29, cervix carcinoma HeLa, and normal fetal lung fibroblasts, MRC-5. Compounds derived from both phenylalanine enantiomer precursors appeared to be the most active against myelogenous leukemia K562 cell lines with a high cytotoxic potential. PB - Wiley-Blackwell, Malden T2 - Journal of Heterocyclic Chemistry T1 - Synthesis, Cytotoxic Activity, and Thermal Studies of Novel N-[(1,3-Diphenylpyrazol-4-yl)methyl] alpha-Amino Acids VL - 47 IS - 4 SP - 850 EP - 856 DO - 10.1002/jhet.400 ER -
@article{ author = "Joksović, Milan D. and Bogdanović, Gordana and Kojić, Vesna and Szecsenyi, Katalin Meszaros and Leovac, Vukadin M. and Jakimov, Dimitar and Trifunović, Snežana S. and Marković, Violeta and Joksović, Ljubinka", year = "2010", abstract = "New N-[(1,3-diphenylpyrazol-4-yl)methyl]alpha-amino acids (1a-i) have been synthesized and tested in vitro for their antiproliferative activity against human myelogenous leukemia K562, colon adenocarcinoma HT-29, cervix carcinoma HeLa, and normal fetal lung fibroblasts, MRC-5. Compounds derived from both phenylalanine enantiomer precursors appeared to be the most active against myelogenous leukemia K562 cell lines with a high cytotoxic potential.", publisher = "Wiley-Blackwell, Malden", journal = "Journal of Heterocyclic Chemistry", title = "Synthesis, Cytotoxic Activity, and Thermal Studies of Novel N-[(1,3-Diphenylpyrazol-4-yl)methyl] alpha-Amino Acids", volume = "47", number = "4", pages = "850-856", doi = "10.1002/jhet.400" }
Joksović, M. D., Bogdanović, G., Kojić, V., Szecsenyi, K. M., Leovac, V. M., Jakimov, D., Trifunović, S. S., Marković, V.,& Joksović, L.. (2010). Synthesis, Cytotoxic Activity, and Thermal Studies of Novel N-[(1,3-Diphenylpyrazol-4-yl)methyl] alpha-Amino Acids. in Journal of Heterocyclic Chemistry Wiley-Blackwell, Malden., 47(4), 850-856. https://doi.org/10.1002/jhet.400
Joksović MD, Bogdanović G, Kojić V, Szecsenyi KM, Leovac VM, Jakimov D, Trifunović SS, Marković V, Joksović L. Synthesis, Cytotoxic Activity, and Thermal Studies of Novel N-[(1,3-Diphenylpyrazol-4-yl)methyl] alpha-Amino Acids. in Journal of Heterocyclic Chemistry. 2010;47(4):850-856. doi:10.1002/jhet.400 .
Joksović, Milan D., Bogdanović, Gordana, Kojić, Vesna, Szecsenyi, Katalin Meszaros, Leovac, Vukadin M., Jakimov, Dimitar, Trifunović, Snežana S., Marković, Violeta, Joksović, Ljubinka, "Synthesis, Cytotoxic Activity, and Thermal Studies of Novel N-[(1,3-Diphenylpyrazol-4-yl)methyl] alpha-Amino Acids" in Journal of Heterocyclic Chemistry, 47, no. 4 (2010):850-856, https://doi.org/10.1002/jhet.400 . .