Kinetics and mechanism of the reactions of Ru(II)-arene complex with some biologically relevant ligands
Само за регистроване кориснике
2011
Чланак у часопису (Објављена верзија)
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The reactions of ruthenium(II)-arene complex [Ru-II(eta(6)-p-cym)(pydc)Cl] (where p-cym = p-isopropyl toluene, pydc = 2,3-pyridinedicarboxylato) with biologically nitrogen-donor nucleophiles, such as guanosine-5'-monophosphate (5'-GMP), guanosine (Guo) and L-histidine (L-His) were studied by UV-Vis spectrophotometry and H-1 NMR spectroscopy. The reactions were studied at pH 2.5 and at 7.2. All reactions were followed under pseudo-first order conditions with large excess of the nucleophiles. The selected nucleophiles have a high affinity for Ru(II)-arene complex. The reactivity of the used ligands follow the same order at both pH values: Guo gt 5'-GMP gt L-His, while the reactions at pH 7.2 are always faster. The negative entropies of activation (Delta S-not equal) support an associative mode of activation. However, the rate constants obtained by H-1 NMR at 295 K in D2O follow the same order of the ligand reactivity. The hydrolysis of the [Ru-II(eta(6)-p-cym)(pydc)Cl] complex was ve...ry fast and completed by the time the first spectrum was measured. Addition of excess of NaCl to equilibrium solutions reversed the hydrolysis. (C) 2011 Elsevier Ltd. All rights reserved.
Кључне речи:
Ru(II) / Arene / Guanosine-5 '-monophosphate / Guanosine / L-HistidineИзвор:
Polyhedron, 2011, 30, 13, 2339-2344Издавач:
- Pergamon-Elsevier Science Ltd, Oxford
Финансирање / пројекти:
- Испитивање механизма реакција комплекса јона прелазних метала са биолошки значајним молекулима (RS-MESTD-Basic Research (BR or ON)-172011)
DOI: 10.1016/j.poly.2011.06.019
ISSN: 0277-5387
WoS: 000294572900022
Scopus: 2-s2.0-79961000993
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Rilak, Ana AU - Petrović, Biljana AU - Grgurić-Šipka, Sanja AU - Tešić, Živoslav Lj. AU - Bugarcic, Zivadin D. PY - 2011 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1197 AB - The reactions of ruthenium(II)-arene complex [Ru-II(eta(6)-p-cym)(pydc)Cl] (where p-cym = p-isopropyl toluene, pydc = 2,3-pyridinedicarboxylato) with biologically nitrogen-donor nucleophiles, such as guanosine-5'-monophosphate (5'-GMP), guanosine (Guo) and L-histidine (L-His) were studied by UV-Vis spectrophotometry and H-1 NMR spectroscopy. The reactions were studied at pH 2.5 and at 7.2. All reactions were followed under pseudo-first order conditions with large excess of the nucleophiles. The selected nucleophiles have a high affinity for Ru(II)-arene complex. The reactivity of the used ligands follow the same order at both pH values: Guo gt 5'-GMP gt L-His, while the reactions at pH 7.2 are always faster. The negative entropies of activation (Delta S-not equal) support an associative mode of activation. However, the rate constants obtained by H-1 NMR at 295 K in D2O follow the same order of the ligand reactivity. The hydrolysis of the [Ru-II(eta(6)-p-cym)(pydc)Cl] complex was very fast and completed by the time the first spectrum was measured. Addition of excess of NaCl to equilibrium solutions reversed the hydrolysis. (C) 2011 Elsevier Ltd. All rights reserved. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Polyhedron T1 - Kinetics and mechanism of the reactions of Ru(II)-arene complex with some biologically relevant ligands VL - 30 IS - 13 SP - 2339 EP - 2344 DO - 10.1016/j.poly.2011.06.019 ER -
@article{ author = "Rilak, Ana and Petrović, Biljana and Grgurić-Šipka, Sanja and Tešić, Živoslav Lj. and Bugarcic, Zivadin D.", year = "2011", abstract = "The reactions of ruthenium(II)-arene complex [Ru-II(eta(6)-p-cym)(pydc)Cl] (where p-cym = p-isopropyl toluene, pydc = 2,3-pyridinedicarboxylato) with biologically nitrogen-donor nucleophiles, such as guanosine-5'-monophosphate (5'-GMP), guanosine (Guo) and L-histidine (L-His) were studied by UV-Vis spectrophotometry and H-1 NMR spectroscopy. The reactions were studied at pH 2.5 and at 7.2. All reactions were followed under pseudo-first order conditions with large excess of the nucleophiles. The selected nucleophiles have a high affinity for Ru(II)-arene complex. The reactivity of the used ligands follow the same order at both pH values: Guo gt 5'-GMP gt L-His, while the reactions at pH 7.2 are always faster. The negative entropies of activation (Delta S-not equal) support an associative mode of activation. However, the rate constants obtained by H-1 NMR at 295 K in D2O follow the same order of the ligand reactivity. The hydrolysis of the [Ru-II(eta(6)-p-cym)(pydc)Cl] complex was very fast and completed by the time the first spectrum was measured. Addition of excess of NaCl to equilibrium solutions reversed the hydrolysis. (C) 2011 Elsevier Ltd. All rights reserved.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Polyhedron", title = "Kinetics and mechanism of the reactions of Ru(II)-arene complex with some biologically relevant ligands", volume = "30", number = "13", pages = "2339-2344", doi = "10.1016/j.poly.2011.06.019" }
Rilak, A., Petrović, B., Grgurić-Šipka, S., Tešić, Ž. Lj.,& Bugarcic, Z. D.. (2011). Kinetics and mechanism of the reactions of Ru(II)-arene complex with some biologically relevant ligands. in Polyhedron Pergamon-Elsevier Science Ltd, Oxford., 30(13), 2339-2344. https://doi.org/10.1016/j.poly.2011.06.019
Rilak A, Petrović B, Grgurić-Šipka S, Tešić ŽL, Bugarcic ZD. Kinetics and mechanism of the reactions of Ru(II)-arene complex with some biologically relevant ligands. in Polyhedron. 2011;30(13):2339-2344. doi:10.1016/j.poly.2011.06.019 .
Rilak, Ana, Petrović, Biljana, Grgurić-Šipka, Sanja, Tešić, Živoslav Lj., Bugarcic, Zivadin D., "Kinetics and mechanism of the reactions of Ru(II)-arene complex with some biologically relevant ligands" in Polyhedron, 30, no. 13 (2011):2339-2344, https://doi.org/10.1016/j.poly.2011.06.019 . .