dc.creator | Gavrović-Jankulović, Marija | |
dc.creator | Dimitrijevic, R. | |
dc.creator | Stojanovic, M. | |
dc.date.accessioned | 2018-11-22T00:17:44Z | |
dc.date.available | 2018-11-22T00:17:44Z | |
dc.date.issued | 2011 | |
dc.identifier.isbn | 978-161761124-7 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/123 | |
dc.description.abstract | Lectins are a highly diverse group of proteins whose biological functions have been associated with the carbohydrate binding activities. Banana lectin is a member of the jacalin-related family of lectins, and belongs to the glucose/mannose specific subgroup. However, it shows a unique specificity for internal α1,3 linkages as well as β1,3 linkages at the reducing termini in branched mannose oligosaccharides, which are components of the-core region of N-linked glycoproteins. As some other plant lectins, banana lectin is stable to the harsh conditions of the human gastrointestinal tract. As a small protein it seems to be able to pass the mucosal barrier and to reach the immune system inducing specific IgG4 antibodies. Banana lectin also displays T cell proliferation in CD3+, CD4+ and CD8+ populations of human PBMCs. It has been recently shown that in vitro stimulation of Balb/c and C57 BL/6 splenocytes by the recombinantly produced banana lectin resulted in the proliferation of T cells and an increased secretion of interferon-gamma. Due to its notable immunomodulatory potential, it has been proposed for the treatment of some Th2-related disorders. This work will discuss banana lectin interactions with the immune system and consider implications for future therapeutic applications. | en |
dc.rights | restrictedAccess | |
dc.source | Bananas: Nutrition, Diseases and Trade Issues | |
dc.title | Banana lectin interactions with the immune system: Implications for future therapeutic applications | en |
dc.type | bookPart | |
dc.rights.license | ARR | |
dc.citation.spage | 307 | |
dc.citation.epage | 318 | |
dc.citation.other | : 307-318 | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-84892341156 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_cherry_123 | |