Electrochemistry and Bioactivity Relationship of Pt(IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N '-Diacetate-Type Ligands
Nema prikaza
Autori
Mihajlović-Lalić, LjiljanaStanković, Dalibor
Poljarević, Jelena
Manojlović, Dragan D.
Sabo, Tibor
Grgurić-Šipka, Sanja
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Pt(IV) complexes with ethylenediamine-N,N'-diacetate-type ligands exhibit strong antitumor activity towards various cancer cell lines. In order to explain their complete mechanisms of action, we examined bioreductive character of eight compounds in total using cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy. Recorded voltammograms of all Pt(IV) complexes with methyl, ethyl, n-propyl and n-butyl esters of (S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid confirmed two successive one-electron transfer steps followed by the loss of the corresponding axial ligands. The redox potential values for Pt(IV) complexes were in the range of -0.92 V lt Ep lt -0.70 V vs. Ag/AgCl, indicating hard reduction. The obtained electrochemical data pointed to the fact that the length of alkyl substituents influences on the reduction as well as on their biological activity. In addition, the electrochemical data were correlated with the biological data b...ut this correlation wasn't established. The reported electrochemical data well correlated with the biological results pointed to the future structural modifications among the investigated compounds and helped select the most suitable candidates for further research.
Ključne reči:
platinum(IV) / anticancer / reduction potential / voltammetryIzvor:
International Journal of Electrochemical Science, 2013, 8, 6, 8433-8441Izdavač:
- Esg, Belgrade
Finansiranje / projekti:
- Racionalni dizajn i sinteza biološki aktivnih i koordinacionih jedinjenja i funkcionalnih materijala, relevantnih u (bio)nanotehnologiji (RS-MESTD-Basic Research (BR or ON)-172035)
- Primena unapređenih oksidacionih procesa i nanostrukturisanih oksidnih materijala za uklanjanje zagađivača iz životne sredine, razvoj i optimizacija instrumentalnih tehnika za praćenje efikasnosti (RS-MESTD-Basic Research (BR or ON)-172030)
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Mihajlović-Lalić, Ljiljana AU - Stanković, Dalibor AU - Poljarević, Jelena AU - Manojlović, Dragan D. AU - Sabo, Tibor AU - Grgurić-Šipka, Sanja PY - 2013 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1392 AB - Pt(IV) complexes with ethylenediamine-N,N'-diacetate-type ligands exhibit strong antitumor activity towards various cancer cell lines. In order to explain their complete mechanisms of action, we examined bioreductive character of eight compounds in total using cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy. Recorded voltammograms of all Pt(IV) complexes with methyl, ethyl, n-propyl and n-butyl esters of (S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid confirmed two successive one-electron transfer steps followed by the loss of the corresponding axial ligands. The redox potential values for Pt(IV) complexes were in the range of -0.92 V lt Ep lt -0.70 V vs. Ag/AgCl, indicating hard reduction. The obtained electrochemical data pointed to the fact that the length of alkyl substituents influences on the reduction as well as on their biological activity. In addition, the electrochemical data were correlated with the biological data but this correlation wasn't established. The reported electrochemical data well correlated with the biological results pointed to the future structural modifications among the investigated compounds and helped select the most suitable candidates for further research. PB - Esg, Belgrade T2 - International Journal of Electrochemical Science T1 - Electrochemistry and Bioactivity Relationship of Pt(IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N '-Diacetate-Type Ligands VL - 8 IS - 6 SP - 8433 EP - 8441 UR - https://hdl.handle.net/21.15107/rcub_cherry_1392 ER -
@article{ author = "Mihajlović-Lalić, Ljiljana and Stanković, Dalibor and Poljarević, Jelena and Manojlović, Dragan D. and Sabo, Tibor and Grgurić-Šipka, Sanja", year = "2013", abstract = "Pt(IV) complexes with ethylenediamine-N,N'-diacetate-type ligands exhibit strong antitumor activity towards various cancer cell lines. In order to explain their complete mechanisms of action, we examined bioreductive character of eight compounds in total using cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy. Recorded voltammograms of all Pt(IV) complexes with methyl, ethyl, n-propyl and n-butyl esters of (S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid confirmed two successive one-electron transfer steps followed by the loss of the corresponding axial ligands. The redox potential values for Pt(IV) complexes were in the range of -0.92 V lt Ep lt -0.70 V vs. Ag/AgCl, indicating hard reduction. The obtained electrochemical data pointed to the fact that the length of alkyl substituents influences on the reduction as well as on their biological activity. In addition, the electrochemical data were correlated with the biological data but this correlation wasn't established. The reported electrochemical data well correlated with the biological results pointed to the future structural modifications among the investigated compounds and helped select the most suitable candidates for further research.", publisher = "Esg, Belgrade", journal = "International Journal of Electrochemical Science", title = "Electrochemistry and Bioactivity Relationship of Pt(IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N '-Diacetate-Type Ligands", volume = "8", number = "6", pages = "8433-8441", url = "https://hdl.handle.net/21.15107/rcub_cherry_1392" }
Mihajlović-Lalić, L., Stanković, D., Poljarević, J., Manojlović, D. D., Sabo, T.,& Grgurić-Šipka, S.. (2013). Electrochemistry and Bioactivity Relationship of Pt(IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N '-Diacetate-Type Ligands. in International Journal of Electrochemical Science Esg, Belgrade., 8(6), 8433-8441. https://hdl.handle.net/21.15107/rcub_cherry_1392
Mihajlović-Lalić L, Stanković D, Poljarević J, Manojlović DD, Sabo T, Grgurić-Šipka S. Electrochemistry and Bioactivity Relationship of Pt(IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N '-Diacetate-Type Ligands. in International Journal of Electrochemical Science. 2013;8(6):8433-8441. https://hdl.handle.net/21.15107/rcub_cherry_1392 .
Mihajlović-Lalić, Ljiljana, Stanković, Dalibor, Poljarević, Jelena, Manojlović, Dragan D., Sabo, Tibor, Grgurić-Šipka, Sanja, "Electrochemistry and Bioactivity Relationship of Pt(IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N '-Diacetate-Type Ligands" in International Journal of Electrochemical Science, 8, no. 6 (2013):8433-8441, https://hdl.handle.net/21.15107/rcub_cherry_1392 .