Influence of the Structure on the Antioxidant Activity of Tetradentate Schiff Bases and their Copper(II) Complexes: Possible Mechanisms
2013
Аутори
Aburas, Najat M.Stevanović, Nikola R.
Milčić, Miloš K.
Lolić, Aleksandar
Natić, Maja
Tešić, Živoslav Lj.
Baošić, Rada
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The influence of the structure on the antioxidant activity of a series of Schiff bases and their copper(II) complexes as well as possible mechanisms of antioxidant activity were investigated. Schiff bases are derived from the condensation of ethane-1,2-diamine or propane-1,2-diamine and pentane-2,4-dione and/or 1-phenylbutane-1,3-dione. The corresponding complexes were synthesized. The antioxidant activity in vitro, determined using reversed-phase thin layer chromatography assay (RP TLC) based on the reaction with 2,2'-diphenyl-1-picrylhydrazyl, was expressed as Trolox equivalent antioxidant capacity (TEAC). The influence of the structure was observed on the basis of interpretable and informative descriptors calculated by hybrid density functional theory (DFT) methods. Structural features responsible for the antioxidant activity of the investigated compounds were discussed. Copper(II) complexes showed a significantly higher antioxidant activity than their corresponding ligands. Calcula...ted quantum-chemical descriptors gave an insight to the reaction mechanism of the scavenging/antioxidant activity of tetradentate Schiff bases and their copper(II) complexes and two different reaction mechanisms were proposed.
Кључне речи:
antioxidant activity / antioxidant mechanism / Schiff base / copper(II) complexes / DFTИзвор:
Journal of the Brazilian Chemical Society, 2013, 24, 8, 1322-Издавач:
- Soc Brasileira Quimica, Sao Paulo
Финансирање / пројекти:
- Корелација структуре и особина природних и синтетичких молекула и њихових комплекса са металима (RS-MESTD-Basic Research (BR or ON)-172017)
DOI: 10.5935/0103-5053.20130167
ISSN: 0103-5053
WoS: 000323725700013
Scopus: 2-s2.0-84883675719
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Aburas, Najat M. AU - Stevanović, Nikola R. AU - Milčić, Miloš K. AU - Lolić, Aleksandar AU - Natić, Maja AU - Tešić, Živoslav Lj. AU - Baošić, Rada PY - 2013 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1396 AB - The influence of the structure on the antioxidant activity of a series of Schiff bases and their copper(II) complexes as well as possible mechanisms of antioxidant activity were investigated. Schiff bases are derived from the condensation of ethane-1,2-diamine or propane-1,2-diamine and pentane-2,4-dione and/or 1-phenylbutane-1,3-dione. The corresponding complexes were synthesized. The antioxidant activity in vitro, determined using reversed-phase thin layer chromatography assay (RP TLC) based on the reaction with 2,2'-diphenyl-1-picrylhydrazyl, was expressed as Trolox equivalent antioxidant capacity (TEAC). The influence of the structure was observed on the basis of interpretable and informative descriptors calculated by hybrid density functional theory (DFT) methods. Structural features responsible for the antioxidant activity of the investigated compounds were discussed. Copper(II) complexes showed a significantly higher antioxidant activity than their corresponding ligands. Calculated quantum-chemical descriptors gave an insight to the reaction mechanism of the scavenging/antioxidant activity of tetradentate Schiff bases and their copper(II) complexes and two different reaction mechanisms were proposed. PB - Soc Brasileira Quimica, Sao Paulo T2 - Journal of the Brazilian Chemical Society T1 - Influence of the Structure on the Antioxidant Activity of Tetradentate Schiff Bases and their Copper(II) Complexes: Possible Mechanisms VL - 24 IS - 8 SP - 1322 DO - 10.5935/0103-5053.20130167 ER -
@article{ author = "Aburas, Najat M. and Stevanović, Nikola R. and Milčić, Miloš K. and Lolić, Aleksandar and Natić, Maja and Tešić, Živoslav Lj. and Baošić, Rada", year = "2013", abstract = "The influence of the structure on the antioxidant activity of a series of Schiff bases and their copper(II) complexes as well as possible mechanisms of antioxidant activity were investigated. Schiff bases are derived from the condensation of ethane-1,2-diamine or propane-1,2-diamine and pentane-2,4-dione and/or 1-phenylbutane-1,3-dione. The corresponding complexes were synthesized. The antioxidant activity in vitro, determined using reversed-phase thin layer chromatography assay (RP TLC) based on the reaction with 2,2'-diphenyl-1-picrylhydrazyl, was expressed as Trolox equivalent antioxidant capacity (TEAC). The influence of the structure was observed on the basis of interpretable and informative descriptors calculated by hybrid density functional theory (DFT) methods. Structural features responsible for the antioxidant activity of the investigated compounds were discussed. Copper(II) complexes showed a significantly higher antioxidant activity than their corresponding ligands. Calculated quantum-chemical descriptors gave an insight to the reaction mechanism of the scavenging/antioxidant activity of tetradentate Schiff bases and their copper(II) complexes and two different reaction mechanisms were proposed.", publisher = "Soc Brasileira Quimica, Sao Paulo", journal = "Journal of the Brazilian Chemical Society", title = "Influence of the Structure on the Antioxidant Activity of Tetradentate Schiff Bases and their Copper(II) Complexes: Possible Mechanisms", volume = "24", number = "8", pages = "1322", doi = "10.5935/0103-5053.20130167" }
Aburas, N. M., Stevanović, N. R., Milčić, M. K., Lolić, A., Natić, M., Tešić, Ž. Lj.,& Baošić, R.. (2013). Influence of the Structure on the Antioxidant Activity of Tetradentate Schiff Bases and their Copper(II) Complexes: Possible Mechanisms. in Journal of the Brazilian Chemical Society Soc Brasileira Quimica, Sao Paulo., 24(8), 1322. https://doi.org/10.5935/0103-5053.20130167
Aburas NM, Stevanović NR, Milčić MK, Lolić A, Natić M, Tešić ŽL, Baošić R. Influence of the Structure on the Antioxidant Activity of Tetradentate Schiff Bases and their Copper(II) Complexes: Possible Mechanisms. in Journal of the Brazilian Chemical Society. 2013;24(8):1322. doi:10.5935/0103-5053.20130167 .
Aburas, Najat M., Stevanović, Nikola R., Milčić, Miloš K., Lolić, Aleksandar, Natić, Maja, Tešić, Živoslav Lj., Baošić, Rada, "Influence of the Structure on the Antioxidant Activity of Tetradentate Schiff Bases and their Copper(II) Complexes: Possible Mechanisms" in Journal of the Brazilian Chemical Society, 24, no. 8 (2013):1322, https://doi.org/10.5935/0103-5053.20130167 . .