N-{[2-(4-Phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides with Dopamine D-2 and 5-Hydroxytryptamine 5HT(1A) Activity: Synthesis, Testing, and Molecular Modeling
Само за регистроване кориснике
2013
Аутори
Šukalović, VladimirBogdan, Anca Elena
Tovilović, Gordana
Ignjatović, Đurđica
Andrić, Deana
Kostić-Rajačić, Slađana
Šoškić, Vukić
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The ratio of affinities toward the dopamine D-2 and the 5-hydroxytryptamine 5-HT1A receptors is one of the important parameters that determine the efficiency of antipsychotic drugs. Here, we present the synthesis of ortho-, meta-, and para-N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides and their structure-activity relationship studies on dopamine D-2 and 5-hydroxytryptamine 5-HT1A receptors. It was shown that the biological activity of the described ligands strongly depends on their topology as well as on the nature of the heteroaryl group in the head of the molecules. Docking simulations together with conformational analysis revealed a rational explanation for the ligands' behavior. The molecular model of receptor-ligand interactions described herein provided us with a tool for the rational design of new compounds with a favorable D-2/5-HT1A profile.
Кључне речи:
Arylpiperazine / Dopamine receptors / Serotonin receptorsИзвор:
Archiv der Pharmazie, 2013, 346, 10, 708-717Издавач:
- Wiley-V C H Verlag Gmbh, Weinheim
Финансирање / пројекти:
- Проучавање односа структуре и активности новосинтетисаних биолошки активних супстанци (RS-MESTD-Basic Research (BR or ON)-172032)
Напомена:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3511
DOI: 10.1002/ardp.201300189
ISSN: 0365-6233
PubMed: 24105736
WoS: 000325497500002
Scopus: 2-s2.0-84885595739
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Šukalović, Vladimir AU - Bogdan, Anca Elena AU - Tovilović, Gordana AU - Ignjatović, Đurđica AU - Andrić, Deana AU - Kostić-Rajačić, Slađana AU - Šoškić, Vukić PY - 2013 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1413 AB - The ratio of affinities toward the dopamine D-2 and the 5-hydroxytryptamine 5-HT1A receptors is one of the important parameters that determine the efficiency of antipsychotic drugs. Here, we present the synthesis of ortho-, meta-, and para-N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides and their structure-activity relationship studies on dopamine D-2 and 5-hydroxytryptamine 5-HT1A receptors. It was shown that the biological activity of the described ligands strongly depends on their topology as well as on the nature of the heteroaryl group in the head of the molecules. Docking simulations together with conformational analysis revealed a rational explanation for the ligands' behavior. The molecular model of receptor-ligand interactions described herein provided us with a tool for the rational design of new compounds with a favorable D-2/5-HT1A profile. PB - Wiley-V C H Verlag Gmbh, Weinheim T2 - Archiv der Pharmazie T1 - N-{[2-(4-Phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides with Dopamine D-2 and 5-Hydroxytryptamine 5HT(1A) Activity: Synthesis, Testing, and Molecular Modeling VL - 346 IS - 10 SP - 708 EP - 717 DO - 10.1002/ardp.201300189 ER -
@article{ author = "Šukalović, Vladimir and Bogdan, Anca Elena and Tovilović, Gordana and Ignjatović, Đurđica and Andrić, Deana and Kostić-Rajačić, Slađana and Šoškić, Vukić", year = "2013", abstract = "The ratio of affinities toward the dopamine D-2 and the 5-hydroxytryptamine 5-HT1A receptors is one of the important parameters that determine the efficiency of antipsychotic drugs. Here, we present the synthesis of ortho-, meta-, and para-N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides and their structure-activity relationship studies on dopamine D-2 and 5-hydroxytryptamine 5-HT1A receptors. It was shown that the biological activity of the described ligands strongly depends on their topology as well as on the nature of the heteroaryl group in the head of the molecules. Docking simulations together with conformational analysis revealed a rational explanation for the ligands' behavior. The molecular model of receptor-ligand interactions described herein provided us with a tool for the rational design of new compounds with a favorable D-2/5-HT1A profile.", publisher = "Wiley-V C H Verlag Gmbh, Weinheim", journal = "Archiv der Pharmazie", title = "N-{[2-(4-Phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides with Dopamine D-2 and 5-Hydroxytryptamine 5HT(1A) Activity: Synthesis, Testing, and Molecular Modeling", volume = "346", number = "10", pages = "708-717", doi = "10.1002/ardp.201300189" }
Šukalović, V., Bogdan, A. E., Tovilović, G., Ignjatović, Đ., Andrić, D., Kostić-Rajačić, S.,& Šoškić, V.. (2013). N-{[2-(4-Phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides with Dopamine D-2 and 5-Hydroxytryptamine 5HT(1A) Activity: Synthesis, Testing, and Molecular Modeling. in Archiv der Pharmazie Wiley-V C H Verlag Gmbh, Weinheim., 346(10), 708-717. https://doi.org/10.1002/ardp.201300189
Šukalović V, Bogdan AE, Tovilović G, Ignjatović Đ, Andrić D, Kostić-Rajačić S, Šoškić V. N-{[2-(4-Phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides with Dopamine D-2 and 5-Hydroxytryptamine 5HT(1A) Activity: Synthesis, Testing, and Molecular Modeling. in Archiv der Pharmazie. 2013;346(10):708-717. doi:10.1002/ardp.201300189 .
Šukalović, Vladimir, Bogdan, Anca Elena, Tovilović, Gordana, Ignjatović, Đurđica, Andrić, Deana, Kostić-Rajačić, Slađana, Šoškić, Vukić, "N-{[2-(4-Phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides with Dopamine D-2 and 5-Hydroxytryptamine 5HT(1A) Activity: Synthesis, Testing, and Molecular Modeling" in Archiv der Pharmazie, 346, no. 10 (2013):708-717, https://doi.org/10.1002/ardp.201300189 . .