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dc.creatorPantelić, Nebojša Đ.
dc.creatorZmejkovski, Bojana B.
dc.creatorTrifunović-Macedoljan, Jelena
dc.creatorSavić, Aleksandar
dc.creatorStanković, Dalibor
dc.creatorDamjanović, Ana
dc.creatorJuranić, Zorica D.
dc.creatorKaluđerović, Goran N.
dc.creatorSabo, Tibor
dc.date.accessioned2018-11-22T00:24:18Z
dc.date.available2018-11-22T00:24:18Z
dc.date.issued2013
dc.identifier.issn0162-0134
dc.identifier.urihttps://cherry.chem.bg.ac.rs/handle/123456789/1422
dc.description.abstractSix novel gold(III) complexes containing O,O'-dialkyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate ([AuCl2{(S,S)-R(2)eddch}]PF6, R = Me, Et, n-Pr, n-Bu, i-Bu, i-Am; 1-6, respectively) were synthesized and characterized by elemental analysis, UV/Visible, IR and NMR spectroscopy, mass spectrometry and differential pulse voltammetry. Density functional theory (DFT) calculations confirmed that diastereoisomer with the N,N' atoms configured (S,S) was the most stable. In vitro antiproliferative activity was determined against human cervix adenocarcinoma HeLa and human myelogenous leukemia K562 tumor cell lines, as well as against rested and stimulated normal immunocompetent human peripheral blood mononuclear cells (PBMC) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Complex 6 expressed the highest activity against K562 cells (IC50 = 3.8 +/- 0.5 mu M). Apoptosis, seen as condensation of HeLa cell nuclei was the mode of cell death induced by complexes 2-6. Complexes 3-6 induced death of K562 cells inhibiting cell entry in mitosis.en
dc.publisherElsevier Science Inc, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Inorganic Biochemistry
dc.subjectGold(III) complexesen
dc.subjectR(2)edda-type ligandsen
dc.subjectDFTen
dc.subjectApoptosisen
dc.subjectCell cycleen
dc.subjectCytotoxicityen
dc.titleGold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N '-diacetateen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТрифуновиц-Мацедољан, Јелена; Савић, Aлександар; Станковић, Далибор; Калудеровиц, Горан Н.; Сабо, Тибор; Пантелиц, Небојса; Јураниц, Зорица; Змејковски, Бојана Б.; Дамјановиц, Aна;
dc.citation.volume128
dc.citation.spage146
dc.citation.epage153
dc.identifier.wos000326060800017
dc.identifier.doi10.1016/j.jinorgbio.2013.08.002
dc.citation.other128: 146-153
dc.citation.rankM21
dc.identifier.pmid23988849
dc.description.otherSupplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3497]
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-84882759461


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