Ruthenium(II)-arene complexes with substituted picolinato ligands: Synthesis, structure, spectroscopic properties and antiproliferative activity
Samo za registrovane korisnike
2014
Autori
Ivanović, IvankaJovanović, Katarina K.
Gligorijević, Nevenka
Radulović, Siniša
Arion, Vladimir B.
Sheweshein, Khalil Salem A. M.
Tešić, Živoslav Lj.
Grgurić-Šipka, Sanja
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
A series of seven new ruthenium(II)-arene complexes of general formula [Ru(eta(6)-p-cymene)(L1-7)Cl], where L1-7 are fluoro, chloro, bromo or methyl derivatives of picolinic acid or isoquinoline-3-carboxylic acid has been synthesized and characterized by elemental analysis, IR, H-1 and C-13 NMR spectroscopy and ESI mass spectrometry. X-ray diffraction studies of two compounds showed the usual piano-stool geometry, with coordination of picolinato ligands through the pyridine nitrogen and the carboxylic group oxygen atom (N/COO- donor set). Cytotoxicity of complexes in vitro has been evaluated in three human tumor cell lines: cervix carcinoma (HeLa), melanoma (FemX), lung adenocarcinoma (A549) and one normal cell line (MRC-5). Complex with isoqinoline-3-carboxylic acid as ligand, exhibited significantly lower cytotoxic activity in normal cells (MRC-5) against high activity observed in panel of tumor cells and prominent cell type selectivity among tumor cells. (C) 2013 Elsevier B. V. All ...rights reserved.
Ključne reči:
Ruthenium(II)-arene / Picolinato ligands / X-ray diffraction / Anticancer activityIzvor:
Journal of Organometallic Chemistry, 2014, 749, 343-349Izdavač:
- Elsevier Science Sa, Lausanne
Finansiranje / projekti:
- Farmakodinamska i farmakogenomska ispitivanja novijih lekova u lečenju solidnih tumora (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41026)
- Korelacija strukture i osobina prirodnih i sintetičkih molekula i njihovih kompleksa sa metalima (RS-MESTD-Basic Research (BR or ON)-172017)
DOI: 10.1016/j.jorganchem.2013.10.023
ISSN: 0022-328X
WoS: 000327939000050
Scopus: 2-s2.0-84887113529
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Ivanović, Ivanka AU - Jovanović, Katarina K. AU - Gligorijević, Nevenka AU - Radulović, Siniša AU - Arion, Vladimir B. AU - Sheweshein, Khalil Salem A. M. AU - Tešić, Živoslav Lj. AU - Grgurić-Šipka, Sanja PY - 2014 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1451 AB - A series of seven new ruthenium(II)-arene complexes of general formula [Ru(eta(6)-p-cymene)(L1-7)Cl], where L1-7 are fluoro, chloro, bromo or methyl derivatives of picolinic acid or isoquinoline-3-carboxylic acid has been synthesized and characterized by elemental analysis, IR, H-1 and C-13 NMR spectroscopy and ESI mass spectrometry. X-ray diffraction studies of two compounds showed the usual piano-stool geometry, with coordination of picolinato ligands through the pyridine nitrogen and the carboxylic group oxygen atom (N/COO- donor set). Cytotoxicity of complexes in vitro has been evaluated in three human tumor cell lines: cervix carcinoma (HeLa), melanoma (FemX), lung adenocarcinoma (A549) and one normal cell line (MRC-5). Complex with isoqinoline-3-carboxylic acid as ligand, exhibited significantly lower cytotoxic activity in normal cells (MRC-5) against high activity observed in panel of tumor cells and prominent cell type selectivity among tumor cells. (C) 2013 Elsevier B. V. All rights reserved. PB - Elsevier Science Sa, Lausanne T2 - Journal of Organometallic Chemistry T1 - Ruthenium(II)-arene complexes with substituted picolinato ligands: Synthesis, structure, spectroscopic properties and antiproliferative activity VL - 749 SP - 343 EP - 349 DO - 10.1016/j.jorganchem.2013.10.023 ER -
@article{ author = "Ivanović, Ivanka and Jovanović, Katarina K. and Gligorijević, Nevenka and Radulović, Siniša and Arion, Vladimir B. and Sheweshein, Khalil Salem A. M. and Tešić, Živoslav Lj. and Grgurić-Šipka, Sanja", year = "2014", abstract = "A series of seven new ruthenium(II)-arene complexes of general formula [Ru(eta(6)-p-cymene)(L1-7)Cl], where L1-7 are fluoro, chloro, bromo or methyl derivatives of picolinic acid or isoquinoline-3-carboxylic acid has been synthesized and characterized by elemental analysis, IR, H-1 and C-13 NMR spectroscopy and ESI mass spectrometry. X-ray diffraction studies of two compounds showed the usual piano-stool geometry, with coordination of picolinato ligands through the pyridine nitrogen and the carboxylic group oxygen atom (N/COO- donor set). Cytotoxicity of complexes in vitro has been evaluated in three human tumor cell lines: cervix carcinoma (HeLa), melanoma (FemX), lung adenocarcinoma (A549) and one normal cell line (MRC-5). Complex with isoqinoline-3-carboxylic acid as ligand, exhibited significantly lower cytotoxic activity in normal cells (MRC-5) against high activity observed in panel of tumor cells and prominent cell type selectivity among tumor cells. (C) 2013 Elsevier B. V. All rights reserved.", publisher = "Elsevier Science Sa, Lausanne", journal = "Journal of Organometallic Chemistry", title = "Ruthenium(II)-arene complexes with substituted picolinato ligands: Synthesis, structure, spectroscopic properties and antiproliferative activity", volume = "749", pages = "343-349", doi = "10.1016/j.jorganchem.2013.10.023" }
Ivanović, I., Jovanović, K. K., Gligorijević, N., Radulović, S., Arion, V. B., Sheweshein, K. S. A. M., Tešić, Ž. Lj.,& Grgurić-Šipka, S.. (2014). Ruthenium(II)-arene complexes with substituted picolinato ligands: Synthesis, structure, spectroscopic properties and antiproliferative activity. in Journal of Organometallic Chemistry Elsevier Science Sa, Lausanne., 749, 343-349. https://doi.org/10.1016/j.jorganchem.2013.10.023
Ivanović I, Jovanović KK, Gligorijević N, Radulović S, Arion VB, Sheweshein KSAM, Tešić ŽL, Grgurić-Šipka S. Ruthenium(II)-arene complexes with substituted picolinato ligands: Synthesis, structure, spectroscopic properties and antiproliferative activity. in Journal of Organometallic Chemistry. 2014;749:343-349. doi:10.1016/j.jorganchem.2013.10.023 .
Ivanović, Ivanka, Jovanović, Katarina K., Gligorijević, Nevenka, Radulović, Siniša, Arion, Vladimir B., Sheweshein, Khalil Salem A. M., Tešić, Živoslav Lj., Grgurić-Šipka, Sanja, "Ruthenium(II)-arene complexes with substituted picolinato ligands: Synthesis, structure, spectroscopic properties and antiproliferative activity" in Journal of Organometallic Chemistry, 749 (2014):343-349, https://doi.org/10.1016/j.jorganchem.2013.10.023 . .