Synthesis, structure and biological activities of Pd(II) and Pt(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone
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2014
Authors
Đorđević, Milena M.Jeremić, Dejan
Rodić, Marko
Simic, Vera S.
Brčeski, Ilija
Leovac, Vukadin M.
Article (Published version)
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The reaction of an ethanolic solution of the newly synthesized 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone (HL) with aqueous solutions of K-2[MCl4] (M = Pd(II), Pt(II)) resulted in neutral complexes of the general formulae [M(L)Cl]. These complexes have a square-planar structure that was achieved by tridentate PNO coordination of the monoprotonated Schiff base and a chloride ligand. The ligand and its metal complexes were analyzed for their antimicrobial activity and their in vitro cytotoxicity in human larynx carcinoma cells (Hep-2) and non-cancerous human lung fibroblast cells (MRC-5). The platinum(II) complex shows cytotoxicity towards Hep-2 cells comparable to oxaliplatin and exhibited improved selectivity for cancer cells. The ligand and its complexes were characterized by elemental analysis, NMR and IR spectroscopy, and single crystal X-ray diffraction analysis. (C) 2013 Elsevier Ltd. All rights reserved.
Keywords:
2-(Diphenylphosphino)benzaldehyde / Adamantane / Hydrazones / Pd(II) and Pt(II) complexes / Crystal structure / Biological activitySource:
Polyhedron, 2014, 68, 234-240Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
Funding / projects:
- Structure-properties relationships of natural and synthetic molecules and their metal complexes (RS-MESTD-Basic Research (BR or ON)-172017)
- Provincial Secretarial and Technological Development of Vojvodina, Republic of Serbia
DOI: 10.1016/j.poly.2013.10.029
ISSN: 0277-5387
WoS: 000331421400031
Scopus: 2-s2.0-84888360858
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Đorđević, Milena M. AU - Jeremić, Dejan AU - Rodić, Marko AU - Simic, Vera S. AU - Brčeski, Ilija AU - Leovac, Vukadin M. PY - 2014 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1504 AB - The reaction of an ethanolic solution of the newly synthesized 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone (HL) with aqueous solutions of K-2[MCl4] (M = Pd(II), Pt(II)) resulted in neutral complexes of the general formulae [M(L)Cl]. These complexes have a square-planar structure that was achieved by tridentate PNO coordination of the monoprotonated Schiff base and a chloride ligand. The ligand and its metal complexes were analyzed for their antimicrobial activity and their in vitro cytotoxicity in human larynx carcinoma cells (Hep-2) and non-cancerous human lung fibroblast cells (MRC-5). The platinum(II) complex shows cytotoxicity towards Hep-2 cells comparable to oxaliplatin and exhibited improved selectivity for cancer cells. The ligand and its complexes were characterized by elemental analysis, NMR and IR spectroscopy, and single crystal X-ray diffraction analysis. (C) 2013 Elsevier Ltd. All rights reserved. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Polyhedron T1 - Synthesis, structure and biological activities of Pd(II) and Pt(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone VL - 68 SP - 234 EP - 240 DO - 10.1016/j.poly.2013.10.029 ER -
@article{ author = "Đorđević, Milena M. and Jeremić, Dejan and Rodić, Marko and Simic, Vera S. and Brčeski, Ilija and Leovac, Vukadin M.", year = "2014", abstract = "The reaction of an ethanolic solution of the newly synthesized 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone (HL) with aqueous solutions of K-2[MCl4] (M = Pd(II), Pt(II)) resulted in neutral complexes of the general formulae [M(L)Cl]. These complexes have a square-planar structure that was achieved by tridentate PNO coordination of the monoprotonated Schiff base and a chloride ligand. The ligand and its metal complexes were analyzed for their antimicrobial activity and their in vitro cytotoxicity in human larynx carcinoma cells (Hep-2) and non-cancerous human lung fibroblast cells (MRC-5). The platinum(II) complex shows cytotoxicity towards Hep-2 cells comparable to oxaliplatin and exhibited improved selectivity for cancer cells. The ligand and its complexes were characterized by elemental analysis, NMR and IR spectroscopy, and single crystal X-ray diffraction analysis. (C) 2013 Elsevier Ltd. All rights reserved.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Polyhedron", title = "Synthesis, structure and biological activities of Pd(II) and Pt(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone", volume = "68", pages = "234-240", doi = "10.1016/j.poly.2013.10.029" }
Đorđević, M. M., Jeremić, D., Rodić, M., Simic, V. S., Brčeski, I.,& Leovac, V. M.. (2014). Synthesis, structure and biological activities of Pd(II) and Pt(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone. in Polyhedron Pergamon-Elsevier Science Ltd, Oxford., 68, 234-240. https://doi.org/10.1016/j.poly.2013.10.029
Đorđević MM, Jeremić D, Rodić M, Simic VS, Brčeski I, Leovac VM. Synthesis, structure and biological activities of Pd(II) and Pt(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone. in Polyhedron. 2014;68:234-240. doi:10.1016/j.poly.2013.10.029 .
Đorđević, Milena M., Jeremić, Dejan, Rodić, Marko, Simic, Vera S., Brčeski, Ilija, Leovac, Vukadin M., "Synthesis, structure and biological activities of Pd(II) and Pt(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone" in Polyhedron, 68 (2014):234-240, https://doi.org/10.1016/j.poly.2013.10.029 . .