Diagnosing multiple drug hypersensitivity in children
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2012
Authors
Atanasković-Marković, MarinaGaeta, Francesco
Gavrović-Jankulović, Marija
Ćirković-Veličković, Tanja
Valluzzi, Rocco Luigi
Romano, Antonino
Article (Published version)
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Background Multiple drug hypersensitivity (MDH) has been defined as a hypersensitivity to two or more chemically different drugs. Two types of MDH have been reported: the first one, which develops to different drugs administered simultaneously and the second type, in which sensitizations develop sequentially. In children, studies which diagnose MDH on the basis of positive allergologic tests to 2 or more chemically different drugs are lacking. Methods We conducted a prospective study evaluating children with histories of MDH by skin tests, patch tests, serum-specific IgE assays, and drug provocation tests. Results A MDH was diagnosed in 7 (2.5%) of the 279 children evaluated who completed the study. The responsible drugs were beta-lactams (penicillins and cephalosporins) in 5 episodes, ibuprofen and anticonvulsants in 3, and erythromycin, fentanyl, methylprednisolone, and cotrimoxazole in 1. Sensitivity to 2 chemically different drugs was diagnosed in 6 children and to 3 drugs in 1 chi...ld. Two of the 7 children presented the first type of MDH, whereas 5 displayed the second one. Conclusions MDH can occur in children, even to drugs other than antibiotics. It is crucial to evaluate children with histories of MDH using both in vivo and in vitro allergologic tests, including challenges. In fact, such approach allows the physician to confirm the diagnosis of MDH in a small percentage of children with histories of MDH, as well as to rule it out in the great majority of them.
Keywords:
challenges / drug provocation tests / multiple drug hypersensitivity / skin tests / patch testsSource:
Pediatric Allergy and Immunology, 2012, 23, 8, 785-791Publisher:
- Wiley-Blackwell, Hoboken
Funding / projects:
- Molecular properties and modifications of some respiratory and nutritional allergens (RS-MESTD-Basic Research (BR or ON)-172024)
- Allergens, antibodies, enzymes and small physiologically important molecules: design, structure, function and relevance (RS-MESTD-Basic Research (BR or ON)-172049)
DOI: 10.1111/pai.12020
ISSN: 0905-6157
PubMed: 23194294
WoS: 000312082800014
Scopus: 2-s2.0-84870517016
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Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Atanasković-Marković, Marina AU - Gaeta, Francesco AU - Gavrović-Jankulović, Marija AU - Ćirković-Veličković, Tanja AU - Valluzzi, Rocco Luigi AU - Romano, Antonino PY - 2012 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1560 AB - Background Multiple drug hypersensitivity (MDH) has been defined as a hypersensitivity to two or more chemically different drugs. Two types of MDH have been reported: the first one, which develops to different drugs administered simultaneously and the second type, in which sensitizations develop sequentially. In children, studies which diagnose MDH on the basis of positive allergologic tests to 2 or more chemically different drugs are lacking. Methods We conducted a prospective study evaluating children with histories of MDH by skin tests, patch tests, serum-specific IgE assays, and drug provocation tests. Results A MDH was diagnosed in 7 (2.5%) of the 279 children evaluated who completed the study. The responsible drugs were beta-lactams (penicillins and cephalosporins) in 5 episodes, ibuprofen and anticonvulsants in 3, and erythromycin, fentanyl, methylprednisolone, and cotrimoxazole in 1. Sensitivity to 2 chemically different drugs was diagnosed in 6 children and to 3 drugs in 1 child. Two of the 7 children presented the first type of MDH, whereas 5 displayed the second one. Conclusions MDH can occur in children, even to drugs other than antibiotics. It is crucial to evaluate children with histories of MDH using both in vivo and in vitro allergologic tests, including challenges. In fact, such approach allows the physician to confirm the diagnosis of MDH in a small percentage of children with histories of MDH, as well as to rule it out in the great majority of them. PB - Wiley-Blackwell, Hoboken T2 - Pediatric Allergy and Immunology T1 - Diagnosing multiple drug hypersensitivity in children VL - 23 IS - 8 SP - 785 EP - 791 DO - 10.1111/pai.12020 ER -
@article{ author = "Atanasković-Marković, Marina and Gaeta, Francesco and Gavrović-Jankulović, Marija and Ćirković-Veličković, Tanja and Valluzzi, Rocco Luigi and Romano, Antonino", year = "2012", abstract = "Background Multiple drug hypersensitivity (MDH) has been defined as a hypersensitivity to two or more chemically different drugs. Two types of MDH have been reported: the first one, which develops to different drugs administered simultaneously and the second type, in which sensitizations develop sequentially. In children, studies which diagnose MDH on the basis of positive allergologic tests to 2 or more chemically different drugs are lacking. Methods We conducted a prospective study evaluating children with histories of MDH by skin tests, patch tests, serum-specific IgE assays, and drug provocation tests. Results A MDH was diagnosed in 7 (2.5%) of the 279 children evaluated who completed the study. The responsible drugs were beta-lactams (penicillins and cephalosporins) in 5 episodes, ibuprofen and anticonvulsants in 3, and erythromycin, fentanyl, methylprednisolone, and cotrimoxazole in 1. Sensitivity to 2 chemically different drugs was diagnosed in 6 children and to 3 drugs in 1 child. Two of the 7 children presented the first type of MDH, whereas 5 displayed the second one. Conclusions MDH can occur in children, even to drugs other than antibiotics. It is crucial to evaluate children with histories of MDH using both in vivo and in vitro allergologic tests, including challenges. In fact, such approach allows the physician to confirm the diagnosis of MDH in a small percentage of children with histories of MDH, as well as to rule it out in the great majority of them.", publisher = "Wiley-Blackwell, Hoboken", journal = "Pediatric Allergy and Immunology", title = "Diagnosing multiple drug hypersensitivity in children", volume = "23", number = "8", pages = "785-791", doi = "10.1111/pai.12020" }
Atanasković-Marković, M., Gaeta, F., Gavrović-Jankulović, M., Ćirković-Veličković, T., Valluzzi, R. L.,& Romano, A.. (2012). Diagnosing multiple drug hypersensitivity in children. in Pediatric Allergy and Immunology Wiley-Blackwell, Hoboken., 23(8), 785-791. https://doi.org/10.1111/pai.12020
Atanasković-Marković M, Gaeta F, Gavrović-Jankulović M, Ćirković-Veličković T, Valluzzi RL, Romano A. Diagnosing multiple drug hypersensitivity in children. in Pediatric Allergy and Immunology. 2012;23(8):785-791. doi:10.1111/pai.12020 .
Atanasković-Marković, Marina, Gaeta, Francesco, Gavrović-Jankulović, Marija, Ćirković-Veličković, Tanja, Valluzzi, Rocco Luigi, Romano, Antonino, "Diagnosing multiple drug hypersensitivity in children" in Pediatric Allergy and Immunology, 23, no. 8 (2012):785-791, https://doi.org/10.1111/pai.12020 . .