Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay
Abstract
This article summarizes the results of using cytokinesis-block micronucleus (CBMN) assay to evaluate the antioxidant potential of heterocyclic compounds. Most studies were carried out with naturally occurring heterocyclic compounds such as plant polyphenols: flavonoids, xanthones, coumarins, and ellagitannins, or plant derived products (juices, extracts, supplements) rich in bioactive heterocyclic compounds. There are also some studies dealing with synthetic heterocyclic antioxidants. CBMN assay is an in vitro study that has been used to evaluate antioxidant and protective effects of heterocyclic compounds on induced chromosome aberration in human lymphocytes.
Keywords:
Antioxidants / CBMN assay / Heterocyclic compounds / Human lymphocytes DNASource:
Mini Reviews in Medicinal Chemistry, 2013, 13, 3, 431-438Publisher:
- Bentham Science Publ Ltd, Sharjah
Funding / projects:
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-MESTD-Basic Research (BR or ON)-172053)
Collections
Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Gođevac, Dejan AU - Tešević, Vele AU - Vajs, Vlatka AU - Milosavljević, Slobodan M. AU - Stanković, Miroslava PY - 2013 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1626 AB - This article summarizes the results of using cytokinesis-block micronucleus (CBMN) assay to evaluate the antioxidant potential of heterocyclic compounds. Most studies were carried out with naturally occurring heterocyclic compounds such as plant polyphenols: flavonoids, xanthones, coumarins, and ellagitannins, or plant derived products (juices, extracts, supplements) rich in bioactive heterocyclic compounds. There are also some studies dealing with synthetic heterocyclic antioxidants. CBMN assay is an in vitro study that has been used to evaluate antioxidant and protective effects of heterocyclic compounds on induced chromosome aberration in human lymphocytes. PB - Bentham Science Publ Ltd, Sharjah T2 - Mini Reviews in Medicinal Chemistry T1 - Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay VL - 13 IS - 3 SP - 431 EP - 438 UR - https://hdl.handle.net/21.15107/rcub_cherry_1626 ER -
@article{ author = "Gođevac, Dejan and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M. and Stanković, Miroslava", year = "2013", abstract = "This article summarizes the results of using cytokinesis-block micronucleus (CBMN) assay to evaluate the antioxidant potential of heterocyclic compounds. Most studies were carried out with naturally occurring heterocyclic compounds such as plant polyphenols: flavonoids, xanthones, coumarins, and ellagitannins, or plant derived products (juices, extracts, supplements) rich in bioactive heterocyclic compounds. There are also some studies dealing with synthetic heterocyclic antioxidants. CBMN assay is an in vitro study that has been used to evaluate antioxidant and protective effects of heterocyclic compounds on induced chromosome aberration in human lymphocytes.", publisher = "Bentham Science Publ Ltd, Sharjah", journal = "Mini Reviews in Medicinal Chemistry", title = "Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay", volume = "13", number = "3", pages = "431-438", url = "https://hdl.handle.net/21.15107/rcub_cherry_1626" }
Gođevac, D., Tešević, V., Vajs, V., Milosavljević, S. M.,& Stanković, M.. (2013). Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay. in Mini Reviews in Medicinal Chemistry Bentham Science Publ Ltd, Sharjah., 13(3), 431-438. https://hdl.handle.net/21.15107/rcub_cherry_1626
Gođevac D, Tešević V, Vajs V, Milosavljević SM, Stanković M. Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay. in Mini Reviews in Medicinal Chemistry. 2013;13(3):431-438. https://hdl.handle.net/21.15107/rcub_cherry_1626 .
Gođevac, Dejan, Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., Stanković, Miroslava, "Antioxidant Evaluation of Heterocyclic Compounds by Cytokinesis-Block Micronucleus Assay" in Mini Reviews in Medicinal Chemistry, 13, no. 3 (2013):431-438, https://hdl.handle.net/21.15107/rcub_cherry_1626 .