Crystal structure, thermal behavior, and microbiological activity of a thiosemicarbazide-type ligand and its cobalt complexes
Samo za registrovane korisnike
2014
Autori
Hollo, BertaRodić, Marko
Vojinović-Ješić, Ljiljana S.
Živković-Radovanović, Vukosava
Vuckovic, Gordana
Leovac, Vukadin M.
Szecsenyi, Katalin Meszaros
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The synthesis of a potentially bioactive mixed-valence Co-III/Co-II complex with 2-acetylpyridine S-methylisothiosemicarbazone (HL) ligand is described. The crystal and molecular structure of the formed [(CoL2)-L-III][(CoCl3)-Cl-II py]center dot Me2CO (I) compound (py stands for pyridine) is determined by single-crystal X-ray crystallography. It's thermal decomposition along with the decomposition of the ligand and six structurally related complexes with formulas [CoL2]NO3 center dot MeOH (1), [CoL2]Br center dot MeOH (2), [CoL2]HSO4 center dot MeOH (3), [CoL2](2)[Co-II(NCS)(4)] (4), [Co(HL)(L)]I-2 center dot 2MeOH (5), and [Co(HL)(L)][(CoCl4)-Cl-II]center dot MeOH (6) was determined by simultaneous TG/DSC measurements. The decomposition pattern is evaluated using TG/DTA-MS data. The results were related to the solvent/moisture content and the decomposition mechanism of the compounds. The antimicrobial activity of the ligand and of all the complexes was tested in vitro for selected gra...m-negative and gram-positive bacteria and fungi. The activity of the ligand against all tested bacteria is comparable with those obtained for standard antibiotics, while it is less active against fungi. Surprisingly, the activity of the complexes is very low. The low antimicrobial activity of the complexes may be in connection with their high thermodynamic and kinetic inertness in solution. The results are also supported by the relatively high thermal stability of the complexes.
Ključne reči:
Co-III and mixed-valence Co-III/Co-II complex / 2-Acetylpyridine S-methylisothiosemicarbazone / TG/DSC / EGA-MS / Biological activityIzvor:
Journal of Thermal Analysis and Calorimetry, 2014, 116, 2, 655-662Izdavač:
- Springer, Dordrecht
Finansiranje / projekti:
- Dizajniranje, sinteza, karakterizacija i procena praktične primene koordinacionih i organometalnih jedinjenja (RS-MESTD-Basic Research (BR or ON)-172014)
DOI: 10.1007/s10973-013-3489-1
ISSN: 1388-6150
WoS: 000334688900016
Scopus: 2-s2.0-84899927596
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Hollo, Berta AU - Rodić, Marko AU - Vojinović-Ješić, Ljiljana S. AU - Živković-Radovanović, Vukosava AU - Vuckovic, Gordana AU - Leovac, Vukadin M. AU - Szecsenyi, Katalin Meszaros PY - 2014 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1767 AB - The synthesis of a potentially bioactive mixed-valence Co-III/Co-II complex with 2-acetylpyridine S-methylisothiosemicarbazone (HL) ligand is described. The crystal and molecular structure of the formed [(CoL2)-L-III][(CoCl3)-Cl-II py]center dot Me2CO (I) compound (py stands for pyridine) is determined by single-crystal X-ray crystallography. It's thermal decomposition along with the decomposition of the ligand and six structurally related complexes with formulas [CoL2]NO3 center dot MeOH (1), [CoL2]Br center dot MeOH (2), [CoL2]HSO4 center dot MeOH (3), [CoL2](2)[Co-II(NCS)(4)] (4), [Co(HL)(L)]I-2 center dot 2MeOH (5), and [Co(HL)(L)][(CoCl4)-Cl-II]center dot MeOH (6) was determined by simultaneous TG/DSC measurements. The decomposition pattern is evaluated using TG/DTA-MS data. The results were related to the solvent/moisture content and the decomposition mechanism of the compounds. The antimicrobial activity of the ligand and of all the complexes was tested in vitro for selected gram-negative and gram-positive bacteria and fungi. The activity of the ligand against all tested bacteria is comparable with those obtained for standard antibiotics, while it is less active against fungi. Surprisingly, the activity of the complexes is very low. The low antimicrobial activity of the complexes may be in connection with their high thermodynamic and kinetic inertness in solution. The results are also supported by the relatively high thermal stability of the complexes. PB - Springer, Dordrecht T2 - Journal of Thermal Analysis and Calorimetry T1 - Crystal structure, thermal behavior, and microbiological activity of a thiosemicarbazide-type ligand and its cobalt complexes VL - 116 IS - 2 SP - 655 EP - 662 DO - 10.1007/s10973-013-3489-1 ER -
@article{ author = "Hollo, Berta and Rodić, Marko and Vojinović-Ješić, Ljiljana S. and Živković-Radovanović, Vukosava and Vuckovic, Gordana and Leovac, Vukadin M. and Szecsenyi, Katalin Meszaros", year = "2014", abstract = "The synthesis of a potentially bioactive mixed-valence Co-III/Co-II complex with 2-acetylpyridine S-methylisothiosemicarbazone (HL) ligand is described. The crystal and molecular structure of the formed [(CoL2)-L-III][(CoCl3)-Cl-II py]center dot Me2CO (I) compound (py stands for pyridine) is determined by single-crystal X-ray crystallography. It's thermal decomposition along with the decomposition of the ligand and six structurally related complexes with formulas [CoL2]NO3 center dot MeOH (1), [CoL2]Br center dot MeOH (2), [CoL2]HSO4 center dot MeOH (3), [CoL2](2)[Co-II(NCS)(4)] (4), [Co(HL)(L)]I-2 center dot 2MeOH (5), and [Co(HL)(L)][(CoCl4)-Cl-II]center dot MeOH (6) was determined by simultaneous TG/DSC measurements. The decomposition pattern is evaluated using TG/DTA-MS data. The results were related to the solvent/moisture content and the decomposition mechanism of the compounds. The antimicrobial activity of the ligand and of all the complexes was tested in vitro for selected gram-negative and gram-positive bacteria and fungi. The activity of the ligand against all tested bacteria is comparable with those obtained for standard antibiotics, while it is less active against fungi. Surprisingly, the activity of the complexes is very low. The low antimicrobial activity of the complexes may be in connection with their high thermodynamic and kinetic inertness in solution. The results are also supported by the relatively high thermal stability of the complexes.", publisher = "Springer, Dordrecht", journal = "Journal of Thermal Analysis and Calorimetry", title = "Crystal structure, thermal behavior, and microbiological activity of a thiosemicarbazide-type ligand and its cobalt complexes", volume = "116", number = "2", pages = "655-662", doi = "10.1007/s10973-013-3489-1" }
Hollo, B., Rodić, M., Vojinović-Ješić, L. S., Živković-Radovanović, V., Vuckovic, G., Leovac, V. M.,& Szecsenyi, K. M.. (2014). Crystal structure, thermal behavior, and microbiological activity of a thiosemicarbazide-type ligand and its cobalt complexes. in Journal of Thermal Analysis and Calorimetry Springer, Dordrecht., 116(2), 655-662. https://doi.org/10.1007/s10973-013-3489-1
Hollo B, Rodić M, Vojinović-Ješić LS, Živković-Radovanović V, Vuckovic G, Leovac VM, Szecsenyi KM. Crystal structure, thermal behavior, and microbiological activity of a thiosemicarbazide-type ligand and its cobalt complexes. in Journal of Thermal Analysis and Calorimetry. 2014;116(2):655-662. doi:10.1007/s10973-013-3489-1 .
Hollo, Berta, Rodić, Marko, Vojinović-Ješić, Ljiljana S., Živković-Radovanović, Vukosava, Vuckovic, Gordana, Leovac, Vukadin M., Szecsenyi, Katalin Meszaros, "Crystal structure, thermal behavior, and microbiological activity of a thiosemicarbazide-type ligand and its cobalt complexes" in Journal of Thermal Analysis and Calorimetry, 116, no. 2 (2014):655-662, https://doi.org/10.1007/s10973-013-3489-1 . .