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Synthesis and characterisation of bismacrocyclic DO3A-amide derivatives - an approach towards metal-responsive PARACEST agents
dc.creator | Cakić, Nevenka | |
dc.creator | Verbić, Tatjana | |
dc.creator | Jelić, Ratomir | |
dc.creator | Platas-Iglesias, Carlos | |
dc.creator | Angelovski, Goran | |
dc.date.accessioned | 2018-11-22T00:34:33Z | |
dc.date.available | 2018-11-22T00:34:33Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1477-9226 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/1911 | |
dc.description.abstract | Three new bismacrocyclic Ln(3+) chelates consisting of triamide derivatives of cyclen with glycine, methyl and tert-butyl substituents (L1-3, respectively) linked to an acyclic EGTA-derived calcium chelator were synthesised as potential MRI contrast agents (EGTA -ethylene glycol-bis(2-aminoethylether)-N, N, N', N'-tetraacetic acid). Eu3+ and Yb3+ complexes of L1-3 were investigated as chemical exchange saturation transfer (CEST) agents. Moderate to minor CEST effects were observed for Eu2L1, Eu2L2 and Yb2L2 complexes in the absence of Ca2+, with negligible changes upon addition of this metal ion. Luminescence steady-state emission and lifetime experiments did not reveal any changes in the coordination environment of the complexes, while the number of inner-sphere water molecules remained constant in the absence and presence of Ca2+. The protonation constants of Eu2L1 and Eu2L2 and stability constants of their complexes with Ca2+, Mg2+ and Zn2+ were determined by means of potentiometric titrations. The results show that the charge of the complex dramatically affects the protonation constants of the EGTA-binding unit. The stability constants of the complexes formed with Ca2+, Mg2+ and Zn2+ are several orders of magnitude lower than those of EGTA. These findings indicate that the nature of Ln(3+) chelates and their charge are the main reasons for the observed results and weaker response of these EGTA-derived triamide derivatives compared to their tricarboxylate analogues. | en |
dc.publisher | Royal Soc Chemistry, Cambridge | |
dc.relation | European COST Action [CM1006] | |
dc.relation | Max-Planck Society | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Dalton Transactions | |
dc.title | Synthesis and characterisation of bismacrocyclic DO3A-amide derivatives - an approach towards metal-responsive PARACEST agents | en |
dc.type | article | |
dc.rights.license | BY | |
dcterms.abstract | Јелиц, Ратомир М.; Платас-Иглесиас, Царлос; Вербић, Татјана; Цакиц, Невенка; Aнгеловски, Горан; | |
dc.citation.volume | 45 | |
dc.citation.issue | 15 | |
dc.citation.spage | 6555 | |
dc.citation.epage | 6565 | |
dc.identifier.wos | 000373994800028 | |
dc.identifier.doi | 10.1039/c5dt04625d | |
dc.citation.other | 45(15): 6555-6565 | |
dc.citation.rank | M22 | |
dc.identifier.pmid | 26956151 | |
dc.description.other | Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3623] | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-84964614019 | |
dc.identifier.fulltext | https://cherry.chem.bg.ac.rs/bitstream/id/8958/1909.pdf |