Development of Sensitive Analytical Approach for the Quantification of alpha-Lipoic Acid Using Boron Doped Diamond Electrode
Apstrakt
A boron doped diamond (BDD) electrode was investigated for use as an electrochemical sensor for alpha-lipoic acid (LA) using amperometric and differential pulse voltammetric detection. LA displays a well expressed oxidation peak at +0.9 V vs. Ag/AgCL in solutions with a pH value of 3. It was found that signals obtained are linearly related to the concentration range from 0.3 to 105 mu M with detection limit of 0.088 mu M. Interferences by common compounds such as ascorbic acid, uric acid and dopamine were tested and the method was successfully applied to the determination of LA in human body fluids where it gave recoveries in the range from 95 to 97%.
Ključne reči:
alpha-Lipoic acid / BDD electrode / electrochemical sensor / sensitivityIzvor:
Analytical Sciences, 2016, 32, 8, 847-851Izdavač:
- Japan Soc Analytical Chemistry, Tokyo
Finansiranje / projekti:
- Primena unapređenih oksidacionih procesa i nanostrukturisanih oksidnih materijala za uklanjanje zagađivača iz životne sredine, razvoj i optimizacija instrumentalnih tehnika za praćenje efikasnosti (RS-MESTD-Basic Research (BR or ON)-172030)
- JoinEU-SEE-Penta Erasmus Mundus scholarship
Napomena:
- Free full text: http://dx.doi.org/10.2116/analsci.32.847
DOI: 10.2116/analsci.32.847
ISSN: 0910-6340
PubMed: 27506710
WoS: 000382184900006
Scopus: 2-s2.0-84983486391
Kolekcije
Institucija/grupa
Inovacioni centar / Innovation CentreTY - JOUR AU - Stanković, Dalibor AU - Mehmeti, Eda AU - Kalcher, Kurt PY - 2016 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1944 AB - A boron doped diamond (BDD) electrode was investigated for use as an electrochemical sensor for alpha-lipoic acid (LA) using amperometric and differential pulse voltammetric detection. LA displays a well expressed oxidation peak at +0.9 V vs. Ag/AgCL in solutions with a pH value of 3. It was found that signals obtained are linearly related to the concentration range from 0.3 to 105 mu M with detection limit of 0.088 mu M. Interferences by common compounds such as ascorbic acid, uric acid and dopamine were tested and the method was successfully applied to the determination of LA in human body fluids where it gave recoveries in the range from 95 to 97%. PB - Japan Soc Analytical Chemistry, Tokyo T2 - Analytical Sciences T1 - Development of Sensitive Analytical Approach for the Quantification of alpha-Lipoic Acid Using Boron Doped Diamond Electrode VL - 32 IS - 8 SP - 847 EP - 851 DO - 10.2116/analsci.32.847 ER -
@article{ author = "Stanković, Dalibor and Mehmeti, Eda and Kalcher, Kurt", year = "2016", abstract = "A boron doped diamond (BDD) electrode was investigated for use as an electrochemical sensor for alpha-lipoic acid (LA) using amperometric and differential pulse voltammetric detection. LA displays a well expressed oxidation peak at +0.9 V vs. Ag/AgCL in solutions with a pH value of 3. It was found that signals obtained are linearly related to the concentration range from 0.3 to 105 mu M with detection limit of 0.088 mu M. Interferences by common compounds such as ascorbic acid, uric acid and dopamine were tested and the method was successfully applied to the determination of LA in human body fluids where it gave recoveries in the range from 95 to 97%.", publisher = "Japan Soc Analytical Chemistry, Tokyo", journal = "Analytical Sciences", title = "Development of Sensitive Analytical Approach for the Quantification of alpha-Lipoic Acid Using Boron Doped Diamond Electrode", volume = "32", number = "8", pages = "847-851", doi = "10.2116/analsci.32.847" }
Stanković, D., Mehmeti, E.,& Kalcher, K.. (2016). Development of Sensitive Analytical Approach for the Quantification of alpha-Lipoic Acid Using Boron Doped Diamond Electrode. in Analytical Sciences Japan Soc Analytical Chemistry, Tokyo., 32(8), 847-851. https://doi.org/10.2116/analsci.32.847
Stanković D, Mehmeti E, Kalcher K. Development of Sensitive Analytical Approach for the Quantification of alpha-Lipoic Acid Using Boron Doped Diamond Electrode. in Analytical Sciences. 2016;32(8):847-851. doi:10.2116/analsci.32.847 .
Stanković, Dalibor, Mehmeti, Eda, Kalcher, Kurt, "Development of Sensitive Analytical Approach for the Quantification of alpha-Lipoic Acid Using Boron Doped Diamond Electrode" in Analytical Sciences, 32, no. 8 (2016):847-851, https://doi.org/10.2116/analsci.32.847 . .