Binding capacity of molecularly imprinted polymers and their nonimprinted analogs
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2015
Članak u časopisu (Objavljena verzija)
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Prikaz svih podataka o dokumentuApstrakt
Molecularly imprinted polymers bind their target compounds at binding sites. The binding sites are typically based on some type of functional group, such as carboxyl group. The total amount of such functional groups and their distribution into available and unavailable groups is not well known. The total binding capacity is usually indirectly determined from adsorption isotherms, which are measured much below the theoretical binding capacity. This work shows that in a variety of differently prepared, methacrylic acid based molecularly imprinted and nonimprinted polymers, all carboxylic groups used for the polymer synthesis are retained in the polymer, 80-90% of them can be accessed by strong bases and essentially the same amount can be used for adsorption of weak bases. This high level of adsorption can only be achieved, however, if the adsorbed weak base is strong enough, if the polymer is sufficiently elastic and if the solvent does not compete too strongly for the binding sites. The...se results may explain why the maximum binding capacities obtained from isotherm measurements are usually not equal to the total amount of available binding sites. This study confirms the usefulness of nonimprinted polymers at high loadings.
Ključne reči:
Adsorption / Binding capacity / Binding site distribution / Molecularly imprinted polymers / Polymer titrationIzvor:
Journal of Separation Science, 2015, 38, 24, 4240-4247Izdavač:
- Wiley-V C H Verlag Gmbh, Weinheim
Finansiranje / projekti:
- Racionalni dizajn i sinteza biološki aktivnih i koordinacionih jedinjenja i funkcionalnih materijala, relevantnih u (bio)nanotehnologiji (RS-MESTD-Basic Research (BR or ON)-172035)
- OTKA, Hungary [K104724]
Napomena:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3342
DOI: 10.1002/jssc.201500874
ISSN: 1615-9306
PubMed: 26462867
WoS: 000367670300012
Scopus: 2-s2.0-84954570720
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Dorko, Zsanett AU - Szakolczai, Anett AU - Verbić, Tatjana AU - Horvai, George PY - 2015 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2021 AB - Molecularly imprinted polymers bind their target compounds at binding sites. The binding sites are typically based on some type of functional group, such as carboxyl group. The total amount of such functional groups and their distribution into available and unavailable groups is not well known. The total binding capacity is usually indirectly determined from adsorption isotherms, which are measured much below the theoretical binding capacity. This work shows that in a variety of differently prepared, methacrylic acid based molecularly imprinted and nonimprinted polymers, all carboxylic groups used for the polymer synthesis are retained in the polymer, 80-90% of them can be accessed by strong bases and essentially the same amount can be used for adsorption of weak bases. This high level of adsorption can only be achieved, however, if the adsorbed weak base is strong enough, if the polymer is sufficiently elastic and if the solvent does not compete too strongly for the binding sites. These results may explain why the maximum binding capacities obtained from isotherm measurements are usually not equal to the total amount of available binding sites. This study confirms the usefulness of nonimprinted polymers at high loadings. PB - Wiley-V C H Verlag Gmbh, Weinheim T2 - Journal of Separation Science T1 - Binding capacity of molecularly imprinted polymers and their nonimprinted analogs VL - 38 IS - 24 SP - 4240 EP - 4247 DO - 10.1002/jssc.201500874 ER -
@article{ author = "Dorko, Zsanett and Szakolczai, Anett and Verbić, Tatjana and Horvai, George", year = "2015", abstract = "Molecularly imprinted polymers bind their target compounds at binding sites. The binding sites are typically based on some type of functional group, such as carboxyl group. The total amount of such functional groups and their distribution into available and unavailable groups is not well known. The total binding capacity is usually indirectly determined from adsorption isotherms, which are measured much below the theoretical binding capacity. This work shows that in a variety of differently prepared, methacrylic acid based molecularly imprinted and nonimprinted polymers, all carboxylic groups used for the polymer synthesis are retained in the polymer, 80-90% of them can be accessed by strong bases and essentially the same amount can be used for adsorption of weak bases. This high level of adsorption can only be achieved, however, if the adsorbed weak base is strong enough, if the polymer is sufficiently elastic and if the solvent does not compete too strongly for the binding sites. These results may explain why the maximum binding capacities obtained from isotherm measurements are usually not equal to the total amount of available binding sites. This study confirms the usefulness of nonimprinted polymers at high loadings.", publisher = "Wiley-V C H Verlag Gmbh, Weinheim", journal = "Journal of Separation Science", title = "Binding capacity of molecularly imprinted polymers and their nonimprinted analogs", volume = "38", number = "24", pages = "4240-4247", doi = "10.1002/jssc.201500874" }
Dorko, Z., Szakolczai, A., Verbić, T.,& Horvai, G.. (2015). Binding capacity of molecularly imprinted polymers and their nonimprinted analogs. in Journal of Separation Science Wiley-V C H Verlag Gmbh, Weinheim., 38(24), 4240-4247. https://doi.org/10.1002/jssc.201500874
Dorko Z, Szakolczai A, Verbić T, Horvai G. Binding capacity of molecularly imprinted polymers and their nonimprinted analogs. in Journal of Separation Science. 2015;38(24):4240-4247. doi:10.1002/jssc.201500874 .
Dorko, Zsanett, Szakolczai, Anett, Verbić, Tatjana, Horvai, George, "Binding capacity of molecularly imprinted polymers and their nonimprinted analogs" in Journal of Separation Science, 38, no. 24 (2015):4240-4247, https://doi.org/10.1002/jssc.201500874 . .