Silver(I) complexes with quinazoline and phthalazine: synthesis, structural characterization and evaluation of biological activities
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Аутори
Savić, Nada D.Glišić, Biljana Đ.
Wadepohl, Hubert
Pavić, Aleksandar
Šenerović, Lidija
Nikodinović-Runić, Jasmina
Đuran, Miloš I.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
New silver.I) complexes with quinazoline (qz) and phthalazine (phtz), [Ag(NO3)(qz)](n) (1) and {[Ag(CH3CN)](2)(mu-phtz)(2)}[BF4](2) (2), have been synthesized and structurally characterized by using different spectroscopic and single-crystal X-ray diffraction techniques. The obtained results revealed that the reaction of AgNO3 with qz at room temperature in a 2 : 1 molar ratio led to the formation of the polynuclear complex 1. However, the reaction of AgBF4 with phtz under the same experimental conditions resulted in the formation of the dinuclear complex 2. The solution behaviour and air/light stability of these silver.I) complexes have been investigated. The complexes 1 and 2, along with the silver.I) salts used for their synthesis, were evaluated by in vitro antimicrobial studies against a panel of microbial strains that lead to many skin and soft tissue, respiratory, wound, and nosocomial infections. The obtained results indicate that all tested silver(I) compounds have good antiba...cterial activity with MIC values in the range from 1.5 to 15.6 mu g mL(-1) against the investigated strains. On the other hand, their antifungal activity against Candida albicans was moderate. In order to determine the therapeutic potential of 1 and 2, their antiproliferative effect on the normal human lung fibroblast cell line MRC5, hemolytic effect on red blood cells and embryotoxicity on zebrafish (Danio rerio) have also been evaluated.
Извор:
MedChemComm, 2016, 7, 2, 282-291Издавач:
- Royal Soc Chemistry, Cambridge
DOI: 10.1039/c5md00494b
ISSN: 2040-2503
WoS: 000370693900009
Scopus: 2-s2.0-84958980981
Колекције
Институција/група
Inovacioni centar / Innovation CentreTY - JOUR AU - Savić, Nada D. AU - Glišić, Biljana Đ. AU - Wadepohl, Hubert AU - Pavić, Aleksandar AU - Šenerović, Lidija AU - Nikodinović-Runić, Jasmina AU - Đuran, Miloš I. PY - 2016 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2056 AB - New silver.I) complexes with quinazoline (qz) and phthalazine (phtz), [Ag(NO3)(qz)](n) (1) and {[Ag(CH3CN)](2)(mu-phtz)(2)}[BF4](2) (2), have been synthesized and structurally characterized by using different spectroscopic and single-crystal X-ray diffraction techniques. The obtained results revealed that the reaction of AgNO3 with qz at room temperature in a 2 : 1 molar ratio led to the formation of the polynuclear complex 1. However, the reaction of AgBF4 with phtz under the same experimental conditions resulted in the formation of the dinuclear complex 2. The solution behaviour and air/light stability of these silver.I) complexes have been investigated. The complexes 1 and 2, along with the silver.I) salts used for their synthesis, were evaluated by in vitro antimicrobial studies against a panel of microbial strains that lead to many skin and soft tissue, respiratory, wound, and nosocomial infections. The obtained results indicate that all tested silver(I) compounds have good antibacterial activity with MIC values in the range from 1.5 to 15.6 mu g mL(-1) against the investigated strains. On the other hand, their antifungal activity against Candida albicans was moderate. In order to determine the therapeutic potential of 1 and 2, their antiproliferative effect on the normal human lung fibroblast cell line MRC5, hemolytic effect on red blood cells and embryotoxicity on zebrafish (Danio rerio) have also been evaluated. PB - Royal Soc Chemistry, Cambridge T2 - MedChemComm T1 - Silver(I) complexes with quinazoline and phthalazine: synthesis, structural characterization and evaluation of biological activities VL - 7 IS - 2 SP - 282 EP - 291 DO - 10.1039/c5md00494b ER -
@article{ author = "Savić, Nada D. and Glišić, Biljana Đ. and Wadepohl, Hubert and Pavić, Aleksandar and Šenerović, Lidija and Nikodinović-Runić, Jasmina and Đuran, Miloš I.", year = "2016", abstract = "New silver.I) complexes with quinazoline (qz) and phthalazine (phtz), [Ag(NO3)(qz)](n) (1) and {[Ag(CH3CN)](2)(mu-phtz)(2)}[BF4](2) (2), have been synthesized and structurally characterized by using different spectroscopic and single-crystal X-ray diffraction techniques. The obtained results revealed that the reaction of AgNO3 with qz at room temperature in a 2 : 1 molar ratio led to the formation of the polynuclear complex 1. However, the reaction of AgBF4 with phtz under the same experimental conditions resulted in the formation of the dinuclear complex 2. The solution behaviour and air/light stability of these silver.I) complexes have been investigated. The complexes 1 and 2, along with the silver.I) salts used for their synthesis, were evaluated by in vitro antimicrobial studies against a panel of microbial strains that lead to many skin and soft tissue, respiratory, wound, and nosocomial infections. The obtained results indicate that all tested silver(I) compounds have good antibacterial activity with MIC values in the range from 1.5 to 15.6 mu g mL(-1) against the investigated strains. On the other hand, their antifungal activity against Candida albicans was moderate. In order to determine the therapeutic potential of 1 and 2, their antiproliferative effect on the normal human lung fibroblast cell line MRC5, hemolytic effect on red blood cells and embryotoxicity on zebrafish (Danio rerio) have also been evaluated.", publisher = "Royal Soc Chemistry, Cambridge", journal = "MedChemComm", title = "Silver(I) complexes with quinazoline and phthalazine: synthesis, structural characterization and evaluation of biological activities", volume = "7", number = "2", pages = "282-291", doi = "10.1039/c5md00494b" }
Savić, N. D., Glišić, B. Đ., Wadepohl, H., Pavić, A., Šenerović, L., Nikodinović-Runić, J.,& Đuran, M. I.. (2016). Silver(I) complexes with quinazoline and phthalazine: synthesis, structural characterization and evaluation of biological activities. in MedChemComm Royal Soc Chemistry, Cambridge., 7(2), 282-291. https://doi.org/10.1039/c5md00494b
Savić ND, Glišić BĐ, Wadepohl H, Pavić A, Šenerović L, Nikodinović-Runić J, Đuran MI. Silver(I) complexes with quinazoline and phthalazine: synthesis, structural characterization and evaluation of biological activities. in MedChemComm. 2016;7(2):282-291. doi:10.1039/c5md00494b .
Savić, Nada D., Glišić, Biljana Đ., Wadepohl, Hubert, Pavić, Aleksandar, Šenerović, Lidija, Nikodinović-Runić, Jasmina, Đuran, Miloš I., "Silver(I) complexes with quinazoline and phthalazine: synthesis, structural characterization and evaluation of biological activities" in MedChemComm, 7, no. 2 (2016):282-291, https://doi.org/10.1039/c5md00494b . .