Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator
Апстракт
Pseudomonas aeruginosa is one of the most dreaded human pathogens, because of its intrinsic resistance to a number of commonly used antibiotics and ability to form sessile communities (biofilms). Innovative treatment strategies are required and that can rely on the attenuation of the pathogenicity and virulence traits. The interruption of the mechanisms of intercellular communication in bacteria (quorum sensing) is one of such promising strategies. A cobalt coordination compound (Co(HL)(2)) synthesized from (E)-2-(2-(pyridin-2-ylmethylene) hydrazinyl)-4-(p-tolyl) thiazole (HL) is reported herein for the first time to inhibit P. aeruginosa 3-oxo-C12-HSL-dependent QS system (LasI/LasR system) and underling phenotypes (biofilm formation and virulence factors). Its interactions with a possible target, the transcriptional activator protein complex LasR-3-oxo-C12-HSL, was studied by molecular modeling with the coordination compound ligand having stronger predicted interactions than those of ...co-crystallized ligand 3-oxo-C12-HSL, as well as known-binder furvina. Transition metal group 9 coordination compounds may be explored in antipathogenic/antibacterial drug design.
Кључне речи:
antibacterial resistance / antivirulence/antipathogenic compounds / biofilm prevention / cobalt complex / furvina / pyocyanin / pyoverdine / quorum sensing inhibition / transcriptional activator protein LasRИзвор:
Molecules, 2018, 23, 6Издавач:
- Mdpi, Basel
Финансирање / пројекти:
- Модулација сигналних путева који контролишу интрацелуларни енергетски баланс у терапији тумора и неуро-имуно-ендокриних поремећаја (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41025)
- FEDER funds through COMPETE2020 Programa Operacional Competitividade e Internacionalizacao (POCI)
- EU COST Action [CM1307, CA15135]
- FEDER Fundo Europeu de Desenvolvimento Regional, through COMPETE2020-Programa Operacional Competitividade e Internacionalizacao (POCI) and Programa Operacional Regional do Norte (NORTE2020) [NORTE-01-0145-FEDER-000005-LEPABE-2-ECO-INNOVATION]
- national funds through FCT Fundacao para a Ciencia e a Tecnologia [SFRH/BPD/98684/2013]
- Estonian Ministry of Education and Research [IUT34-14]
Напомена:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3141
DOI: 10.3390/molecules23061385
ISSN: 1420-3049
PubMed: 29890626
WoS: 000435875400146
Scopus: 2-s2.0-85048340576
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Borges, Anabela AU - Simoes, Manuel AU - Todorović, Tamara AU - Filipović, Nenad R. AU - Garcia-Sosa, Alfonso T. PY - 2018 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2163 AB - Pseudomonas aeruginosa is one of the most dreaded human pathogens, because of its intrinsic resistance to a number of commonly used antibiotics and ability to form sessile communities (biofilms). Innovative treatment strategies are required and that can rely on the attenuation of the pathogenicity and virulence traits. The interruption of the mechanisms of intercellular communication in bacteria (quorum sensing) is one of such promising strategies. A cobalt coordination compound (Co(HL)(2)) synthesized from (E)-2-(2-(pyridin-2-ylmethylene) hydrazinyl)-4-(p-tolyl) thiazole (HL) is reported herein for the first time to inhibit P. aeruginosa 3-oxo-C12-HSL-dependent QS system (LasI/LasR system) and underling phenotypes (biofilm formation and virulence factors). Its interactions with a possible target, the transcriptional activator protein complex LasR-3-oxo-C12-HSL, was studied by molecular modeling with the coordination compound ligand having stronger predicted interactions than those of co-crystallized ligand 3-oxo-C12-HSL, as well as known-binder furvina. Transition metal group 9 coordination compounds may be explored in antipathogenic/antibacterial drug design. PB - Mdpi, Basel T2 - Molecules T1 - Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator VL - 23 IS - 6 DO - 10.3390/molecules23061385 ER -
@article{ author = "Borges, Anabela and Simoes, Manuel and Todorović, Tamara and Filipović, Nenad R. and Garcia-Sosa, Alfonso T.", year = "2018", abstract = "Pseudomonas aeruginosa is one of the most dreaded human pathogens, because of its intrinsic resistance to a number of commonly used antibiotics and ability to form sessile communities (biofilms). Innovative treatment strategies are required and that can rely on the attenuation of the pathogenicity and virulence traits. The interruption of the mechanisms of intercellular communication in bacteria (quorum sensing) is one of such promising strategies. A cobalt coordination compound (Co(HL)(2)) synthesized from (E)-2-(2-(pyridin-2-ylmethylene) hydrazinyl)-4-(p-tolyl) thiazole (HL) is reported herein for the first time to inhibit P. aeruginosa 3-oxo-C12-HSL-dependent QS system (LasI/LasR system) and underling phenotypes (biofilm formation and virulence factors). Its interactions with a possible target, the transcriptional activator protein complex LasR-3-oxo-C12-HSL, was studied by molecular modeling with the coordination compound ligand having stronger predicted interactions than those of co-crystallized ligand 3-oxo-C12-HSL, as well as known-binder furvina. Transition metal group 9 coordination compounds may be explored in antipathogenic/antibacterial drug design.", publisher = "Mdpi, Basel", journal = "Molecules", title = "Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator", volume = "23", number = "6", doi = "10.3390/molecules23061385" }
Borges, A., Simoes, M., Todorović, T., Filipović, N. R.,& Garcia-Sosa, A. T.. (2018). Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator. in Molecules Mdpi, Basel., 23(6). https://doi.org/10.3390/molecules23061385
Borges A, Simoes M, Todorović T, Filipović NR, Garcia-Sosa AT. Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator. in Molecules. 2018;23(6). doi:10.3390/molecules23061385 .
Borges, Anabela, Simoes, Manuel, Todorović, Tamara, Filipović, Nenad R., Garcia-Sosa, Alfonso T., "Cobalt Complex with Thiazole-Based Ligand as New Pseudomonas aeruginosa Quorum Quencher, Biofilm Inhibitor and Virulence Attenuator" in Molecules, 23, no. 6 (2018), https://doi.org/10.3390/molecules23061385 . .