Benzothiazole carbamates and amides as antiproliferative species
Само за регистроване кориснике
2018
Аутори
Videnović, MilicaMojsin, Marija
Stevanović, Milena
Opsenica, Igor
Srdić-Rajić, Tatjana
Šolaja, Bogdan A.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A series of new benzothiazole-based carbamates and amides were synthesized and their antiproliferative activity was determined. Derivatives with profound activity were identified and further investigated for their possible mechanism of action. It was found that these compounds induce specific apoptosis, G2/M cell cycle arrest and decrease ROS level in MCF-7 human breast cancer cell line. Moreover, sub-micromolar antiproliferative activity of examined carbamates against NT2/D1 testicular embryonal carcinoma was shown. The most potent derivatives strongly inhibited NT2/D1 cell migration and invasiveness. (C) 2018 Elsevier Masson SAS. All rights reserved.
Кључне речи:
Benzothiazoles / Antiproliferative / MCF-7 / NT2/D1 / AnoikisИзвор:
European Journal of Medicinal Chemistry, 2018, 157, 1096-1114Издавач:
- Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
Финансирање / пројекти:
- Синтеза аминохинолина и њихових деривата као антималарика и инхибитора ботулинум неуротоксина А (RS-MESTD-Basic Research (BR or ON)-172008)
- Проучавање сигналних путева и епигенетичких механизама укључених у контролу експресије хуманих SOX гена: даље расветљавање њихове улоге у одређивању судбине и диференцијацији ћелија (RS-MESTD-Basic Research (BR or ON)-173051)
- Serbian Academy of Sciences and Arts
Напомена:
- Peer-reviewed manuscript: http://cherry.chem.bg.ac.rs/handle/123456789/2960
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/2961
DOI: 10.1016/j.ejmech.2018.08.067
ISSN: 0223-5234
PubMed: 30179747
WoS: 000447480000079
Scopus: 2-s2.0-85054063702
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Videnović, Milica AU - Mojsin, Marija AU - Stevanović, Milena AU - Opsenica, Igor AU - Srdić-Rajić, Tatjana AU - Šolaja, Bogdan A. PY - 2018 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2233 AB - A series of new benzothiazole-based carbamates and amides were synthesized and their antiproliferative activity was determined. Derivatives with profound activity were identified and further investigated for their possible mechanism of action. It was found that these compounds induce specific apoptosis, G2/M cell cycle arrest and decrease ROS level in MCF-7 human breast cancer cell line. Moreover, sub-micromolar antiproliferative activity of examined carbamates against NT2/D1 testicular embryonal carcinoma was shown. The most potent derivatives strongly inhibited NT2/D1 cell migration and invasiveness. (C) 2018 Elsevier Masson SAS. All rights reserved. PB - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux T2 - European Journal of Medicinal Chemistry T1 - Benzothiazole carbamates and amides as antiproliferative species VL - 157 SP - 1096 EP - 1114 DO - 10.1016/j.ejmech.2018.08.067 ER -
@article{ author = "Videnović, Milica and Mojsin, Marija and Stevanović, Milena and Opsenica, Igor and Srdić-Rajić, Tatjana and Šolaja, Bogdan A.", year = "2018", abstract = "A series of new benzothiazole-based carbamates and amides were synthesized and their antiproliferative activity was determined. Derivatives with profound activity were identified and further investigated for their possible mechanism of action. It was found that these compounds induce specific apoptosis, G2/M cell cycle arrest and decrease ROS level in MCF-7 human breast cancer cell line. Moreover, sub-micromolar antiproliferative activity of examined carbamates against NT2/D1 testicular embryonal carcinoma was shown. The most potent derivatives strongly inhibited NT2/D1 cell migration and invasiveness. (C) 2018 Elsevier Masson SAS. All rights reserved.", publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux", journal = "European Journal of Medicinal Chemistry", title = "Benzothiazole carbamates and amides as antiproliferative species", volume = "157", pages = "1096-1114", doi = "10.1016/j.ejmech.2018.08.067" }
Videnović, M., Mojsin, M., Stevanović, M., Opsenica, I., Srdić-Rajić, T.,& Šolaja, B. A.. (2018). Benzothiazole carbamates and amides as antiproliferative species. in European Journal of Medicinal Chemistry Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 157, 1096-1114. https://doi.org/10.1016/j.ejmech.2018.08.067
Videnović M, Mojsin M, Stevanović M, Opsenica I, Srdić-Rajić T, Šolaja BA. Benzothiazole carbamates and amides as antiproliferative species. in European Journal of Medicinal Chemistry. 2018;157:1096-1114. doi:10.1016/j.ejmech.2018.08.067 .
Videnović, Milica, Mojsin, Marija, Stevanović, Milena, Opsenica, Igor, Srdić-Rajić, Tatjana, Šolaja, Bogdan A., "Benzothiazole carbamates and amides as antiproliferative species" in European Journal of Medicinal Chemistry, 157 (2018):1096-1114, https://doi.org/10.1016/j.ejmech.2018.08.067 . .