Oxidative stress and hemoglobin-cholesterol adduct in renal patients with different LDL phenotypes
Само за регистроване кориснике
2016
Аутори
Miljković, MilicaKotur-Stevuljević, Jelena
Stefanović, Aleksandra
Željković, Aleksandra
Vekić, Jelena
Gojković, Tamara
Bogavac-Stanojević, Nataša
Nikolić, Milan
Simić-Ogrizović, Sanja
Spasojević-Kalimanovska, Vesna
Jelić-Ivanović, Zorana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Unfavorable lipid profile is a major risk factor for cardiovascular disease in renal pathology. In this study, we compared chronic renal patients and healthy controls with different LDL phenotypes (A or B) in respect of various biochemical parameters related to cardiovascular disease. Oxidative stress and anti-oxidative defense parameters [thiobarbituric acid-reacting substances (TBARS), total oxidative status (TOS), total anti-oxidative status (TAS), total protein sulfhydryl (-SH) groups], as well as red blood cell cholesterol distribution were assessed in 40 renal patients and 40 control subjects by standardized assays. LDL particle diameters were determined by polyacrylamide gradient gel electrophoresis. LDL particles are subdivided according to their size into large LDL A phenotype (diameter gt 25.5 nm) and small LDL B phenotype (diameter aecurrency sign25.5 nm). Renal patients with LDL A phenotype had increased oxidative stress (TOS: p lt 0.01, and TBARS: p lt 0.001) and dec...reased total SH- groups (p lt 0.001) compared to controls with the same LDL phenotype. A notable decrease in hemoglobin-cholesterol adduct was detected in patients with LDL A phenotype (p lt 0.001) and LDL B phenotype (p lt 0.05) compared with appropriate controls. LDL B phenotype was characterized with increased TBARS (p lt 0.05) compared with LDL A phenotype in control group. Increased oxidative stress, decreased anti-oxidative defense followed with unfavorable changes in hemoglobin-cholesterol binding capacity, could have important influence on cardiovascular disease risk in renal patients regardless of LDL phenotype.
Кључне речи:
LDL particles / Hemoglobin-cholesterol adduct / Oxidative stress / Anti-oxidative defense / Red blood cell membrane cholesterolИзвор:
International Urology and Nephrology, 2016, 48, 10, 1683-1690Издавач:
- Springer, Dordrecht
Финансирање / пројекти:
- Интерактивна улога дислипидемије, оксидативног стреса и инфламације у атеросклерози и другим болестима: генетички и биохемијски маркери (RS-MESTD-Basic Research (BR or ON)-175035)
- Рационални дизајн и синтеза биолошки активних и координационих једињења и функционалних материјала, релевантних у (био)нанотехнологији (RS-MESTD-Basic Research (BR or ON)-172035)
DOI: 10.1007/s11255-016-1358-0
ISSN: 0301-1623
PubMed: 27412679
WoS: 000384563100019
Scopus: 2-s2.0-84978148560
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Miljković, Milica AU - Kotur-Stevuljević, Jelena AU - Stefanović, Aleksandra AU - Željković, Aleksandra AU - Vekić, Jelena AU - Gojković, Tamara AU - Bogavac-Stanojević, Nataša AU - Nikolić, Milan AU - Simić-Ogrizović, Sanja AU - Spasojević-Kalimanovska, Vesna AU - Jelić-Ivanović, Zorana PY - 2016 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2320 AB - Unfavorable lipid profile is a major risk factor for cardiovascular disease in renal pathology. In this study, we compared chronic renal patients and healthy controls with different LDL phenotypes (A or B) in respect of various biochemical parameters related to cardiovascular disease. Oxidative stress and anti-oxidative defense parameters [thiobarbituric acid-reacting substances (TBARS), total oxidative status (TOS), total anti-oxidative status (TAS), total protein sulfhydryl (-SH) groups], as well as red blood cell cholesterol distribution were assessed in 40 renal patients and 40 control subjects by standardized assays. LDL particle diameters were determined by polyacrylamide gradient gel electrophoresis. LDL particles are subdivided according to their size into large LDL A phenotype (diameter gt 25.5 nm) and small LDL B phenotype (diameter aecurrency sign25.5 nm). Renal patients with LDL A phenotype had increased oxidative stress (TOS: p lt 0.01, and TBARS: p lt 0.001) and decreased total SH- groups (p lt 0.001) compared to controls with the same LDL phenotype. A notable decrease in hemoglobin-cholesterol adduct was detected in patients with LDL A phenotype (p lt 0.001) and LDL B phenotype (p lt 0.05) compared with appropriate controls. LDL B phenotype was characterized with increased TBARS (p lt 0.05) compared with LDL A phenotype in control group. Increased oxidative stress, decreased anti-oxidative defense followed with unfavorable changes in hemoglobin-cholesterol binding capacity, could have important influence on cardiovascular disease risk in renal patients regardless of LDL phenotype. PB - Springer, Dordrecht T2 - International Urology and Nephrology T1 - Oxidative stress and hemoglobin-cholesterol adduct in renal patients with different LDL phenotypes VL - 48 IS - 10 SP - 1683 EP - 1690 DO - 10.1007/s11255-016-1358-0 ER -
@article{ author = "Miljković, Milica and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Željković, Aleksandra and Vekić, Jelena and Gojković, Tamara and Bogavac-Stanojević, Nataša and Nikolić, Milan and Simić-Ogrizović, Sanja and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana", year = "2016", abstract = "Unfavorable lipid profile is a major risk factor for cardiovascular disease in renal pathology. In this study, we compared chronic renal patients and healthy controls with different LDL phenotypes (A or B) in respect of various biochemical parameters related to cardiovascular disease. Oxidative stress and anti-oxidative defense parameters [thiobarbituric acid-reacting substances (TBARS), total oxidative status (TOS), total anti-oxidative status (TAS), total protein sulfhydryl (-SH) groups], as well as red blood cell cholesterol distribution were assessed in 40 renal patients and 40 control subjects by standardized assays. LDL particle diameters were determined by polyacrylamide gradient gel electrophoresis. LDL particles are subdivided according to their size into large LDL A phenotype (diameter gt 25.5 nm) and small LDL B phenotype (diameter aecurrency sign25.5 nm). Renal patients with LDL A phenotype had increased oxidative stress (TOS: p lt 0.01, and TBARS: p lt 0.001) and decreased total SH- groups (p lt 0.001) compared to controls with the same LDL phenotype. A notable decrease in hemoglobin-cholesterol adduct was detected in patients with LDL A phenotype (p lt 0.001) and LDL B phenotype (p lt 0.05) compared with appropriate controls. LDL B phenotype was characterized with increased TBARS (p lt 0.05) compared with LDL A phenotype in control group. Increased oxidative stress, decreased anti-oxidative defense followed with unfavorable changes in hemoglobin-cholesterol binding capacity, could have important influence on cardiovascular disease risk in renal patients regardless of LDL phenotype.", publisher = "Springer, Dordrecht", journal = "International Urology and Nephrology", title = "Oxidative stress and hemoglobin-cholesterol adduct in renal patients with different LDL phenotypes", volume = "48", number = "10", pages = "1683-1690", doi = "10.1007/s11255-016-1358-0" }
Miljković, M., Kotur-Stevuljević, J., Stefanović, A., Željković, A., Vekić, J., Gojković, T., Bogavac-Stanojević, N., Nikolić, M., Simić-Ogrizović, S., Spasojević-Kalimanovska, V.,& Jelić-Ivanović, Z.. (2016). Oxidative stress and hemoglobin-cholesterol adduct in renal patients with different LDL phenotypes. in International Urology and Nephrology Springer, Dordrecht., 48(10), 1683-1690. https://doi.org/10.1007/s11255-016-1358-0
Miljković M, Kotur-Stevuljević J, Stefanović A, Željković A, Vekić J, Gojković T, Bogavac-Stanojević N, Nikolić M, Simić-Ogrizović S, Spasojević-Kalimanovska V, Jelić-Ivanović Z. Oxidative stress and hemoglobin-cholesterol adduct in renal patients with different LDL phenotypes. in International Urology and Nephrology. 2016;48(10):1683-1690. doi:10.1007/s11255-016-1358-0 .
Miljković, Milica, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Željković, Aleksandra, Vekić, Jelena, Gojković, Tamara, Bogavac-Stanojević, Nataša, Nikolić, Milan, Simić-Ogrizović, Sanja, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, "Oxidative stress and hemoglobin-cholesterol adduct in renal patients with different LDL phenotypes" in International Urology and Nephrology, 48, no. 10 (2016):1683-1690, https://doi.org/10.1007/s11255-016-1358-0 . .