The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1
Само за регистроване кориснике
2016
Аутори
Apostolović, DanijelaSanchez-Vidaurre, Sara
Waden, Konrad
Curin, Mirela
Grundström, Jeanette
Gafvelin, Guro
Ćirković-Veličković, Tanja
Gronlund, Hans
Thomas, Wayne R.
Valenta, Rudolf
Hamsten, Carl
van Hage, Marianne
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat-but also in dog-allergic patients.
Кључне речи:
Can f 1 / cat allergy / cross-reactivity / dog allergy / Fel d 7Извор:
Allergy, 2016, 71, 10, 1490-1495Издавач:
- Wiley-Blackwell, Hoboken
Финансирање / пројекти:
- Молекуларне особине и модификације неких респираторних и нутритивних алергена (RS-MESTD-Basic Research (BR or ON)-172024)
- Reinforcement of the Faculty of Chemistry, University of Belgrade, towards becoming a Center of Excellence in the region of WB for Molecular Biotechnology and Food research (EU-FP7-256716)
- Stockholm County Council
- Karolinska Institutet
- Austrian Science Fund (FWF) [F4605]
- Swedish Association for Allergology
- Swedish Cancer and Allergy Foundation
- King Gustaf V 80th Birthday Foundation
- Magnus Bergvall Foundation
- Swedish Research Council
- Swedish Asthma and Allergy Associations Research Foundation
- Swedish Heart-Lung Foundation
- Center for Inflammatory Diseases
- Hesselman Foundation
Напомена:
- Free full text: https://doi.org/10.1111/all.12955
- Peer-reviewed manuscript: http://cherry.chem.bg.ac.rs/handle/123456789/3650
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3651
DOI: 10.1111/all.12955
ISSN: 0105-4538
PubMed: 27289080
WoS: 000386085800014
Scopus: 2-s2.0-84978909754
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Apostolović, Danijela AU - Sanchez-Vidaurre, Sara AU - Waden, Konrad AU - Curin, Mirela AU - Grundström, Jeanette AU - Gafvelin, Guro AU - Ćirković-Veličković, Tanja AU - Gronlund, Hans AU - Thomas, Wayne R. AU - Valenta, Rudolf AU - Hamsten, Carl AU - van Hage, Marianne PY - 2016 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2337 AB - We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat-but also in dog-allergic patients. PB - Wiley-Blackwell, Hoboken T2 - Allergy T1 - The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1 VL - 71 IS - 10 SP - 1490 EP - 1495 DO - 10.1111/all.12955 ER -
@article{ author = "Apostolović, Danijela and Sanchez-Vidaurre, Sara and Waden, Konrad and Curin, Mirela and Grundström, Jeanette and Gafvelin, Guro and Ćirković-Veličković, Tanja and Gronlund, Hans and Thomas, Wayne R. and Valenta, Rudolf and Hamsten, Carl and van Hage, Marianne", year = "2016", abstract = "We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat-but also in dog-allergic patients.", publisher = "Wiley-Blackwell, Hoboken", journal = "Allergy", title = "The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1", volume = "71", number = "10", pages = "1490-1495", doi = "10.1111/all.12955" }
Apostolović, D., Sanchez-Vidaurre, S., Waden, K., Curin, M., Grundström, J., Gafvelin, G., Ćirković-Veličković, T., Gronlund, H., Thomas, W. R., Valenta, R., Hamsten, C.,& van Hage, M.. (2016). The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1. in Allergy Wiley-Blackwell, Hoboken., 71(10), 1490-1495. https://doi.org/10.1111/all.12955
Apostolović D, Sanchez-Vidaurre S, Waden K, Curin M, Grundström J, Gafvelin G, Ćirković-Veličković T, Gronlund H, Thomas WR, Valenta R, Hamsten C, van Hage M. The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1. in Allergy. 2016;71(10):1490-1495. doi:10.1111/all.12955 .
Apostolović, Danijela, Sanchez-Vidaurre, Sara, Waden, Konrad, Curin, Mirela, Grundström, Jeanette, Gafvelin, Guro, Ćirković-Veličković, Tanja, Gronlund, Hans, Thomas, Wayne R., Valenta, Rudolf, Hamsten, Carl, van Hage, Marianne, "The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1" in Allergy, 71, no. 10 (2016):1490-1495, https://doi.org/10.1111/all.12955 . .