Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells
Abstract
The growth inhibition of stictic acid, a secondary metabolite isolated from the lichen Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), was evaluated in vitro on three human cell lines for the first time. The cell lines HT-29 and MCF-7 were utilized for measuring the activity of stictic acid against cancer cells, while the cell line MRC-5 was selected for estimation of its effect on normal cells. The results suggest a moderate anticancer activity (IC50 value for the cell line HT-29 was 29.29 mu g/ml) and a low growth inhibition on nonmalignant cells (IC50 value for the cell line MRC-5 was 2478.40 mu g/ml) of stictic acid. This natural product can be considered as a promising lead compound for the design of novel human colon adenocarcinoma drugs. (C) 2013 Production and hosting by Elsevier B.V.
Keywords:
Lobaria pulmonaria / beta-Orcinol depsidone / MTT growth inhibition assay / Human colon adenocarcinomaSource:
Arabian Journal of Chemistry, 2017, 10, 1240-1242Publisher:
- Elsevier Science Bv, Amsterdam
Funding / projects:
- Synthesis and biological testing of new mimics or derivatives of selected cytotoxic lactones, antitumor agent tiazofurin and natural naphthenic acids (RS-MESTD-Basic Research (BR or ON)-172006)
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-MESTD-Basic Research (BR or ON)-172053)
- The membranes as sites of interaction between the intracellular and apoplastic environments: studies of the bioenergetics and signaling using biophysical and biochemical techniques. (RS-MESTD-Basic Research (BR or ON)-173040)
DOI: 10.1016/j.arabjc.2013.03.003
ISSN: 1878-5352
WoS: 000399414100163
Scopus: 2-s2.0-84875689064
Collections
Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Pejin, Boris AU - Iodice, Carmine AU - Bogdanović, Gordana AU - Kojić, Vesna AU - Tešević, Vele PY - 2017 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2446 AB - The growth inhibition of stictic acid, a secondary metabolite isolated from the lichen Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), was evaluated in vitro on three human cell lines for the first time. The cell lines HT-29 and MCF-7 were utilized for measuring the activity of stictic acid against cancer cells, while the cell line MRC-5 was selected for estimation of its effect on normal cells. The results suggest a moderate anticancer activity (IC50 value for the cell line HT-29 was 29.29 mu g/ml) and a low growth inhibition on nonmalignant cells (IC50 value for the cell line MRC-5 was 2478.40 mu g/ml) of stictic acid. This natural product can be considered as a promising lead compound for the design of novel human colon adenocarcinoma drugs. (C) 2013 Production and hosting by Elsevier B.V. PB - Elsevier Science Bv, Amsterdam T2 - Arabian Journal of Chemistry T1 - Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells VL - 10 SP - 1240 EP - 1242 DO - 10.1016/j.arabjc.2013.03.003 ER -
@article{ author = "Pejin, Boris and Iodice, Carmine and Bogdanović, Gordana and Kojić, Vesna and Tešević, Vele", year = "2017", abstract = "The growth inhibition of stictic acid, a secondary metabolite isolated from the lichen Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), was evaluated in vitro on three human cell lines for the first time. The cell lines HT-29 and MCF-7 were utilized for measuring the activity of stictic acid against cancer cells, while the cell line MRC-5 was selected for estimation of its effect on normal cells. The results suggest a moderate anticancer activity (IC50 value for the cell line HT-29 was 29.29 mu g/ml) and a low growth inhibition on nonmalignant cells (IC50 value for the cell line MRC-5 was 2478.40 mu g/ml) of stictic acid. This natural product can be considered as a promising lead compound for the design of novel human colon adenocarcinoma drugs. (C) 2013 Production and hosting by Elsevier B.V.", publisher = "Elsevier Science Bv, Amsterdam", journal = "Arabian Journal of Chemistry", title = "Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells", volume = "10", pages = "1240-1242", doi = "10.1016/j.arabjc.2013.03.003" }
Pejin, B., Iodice, C., Bogdanović, G., Kojić, V.,& Tešević, V.. (2017). Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells. in Arabian Journal of Chemistry Elsevier Science Bv, Amsterdam., 10, 1240-1242. https://doi.org/10.1016/j.arabjc.2013.03.003
Pejin B, Iodice C, Bogdanović G, Kojić V, Tešević V. Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells. in Arabian Journal of Chemistry. 2017;10:1240-1242. doi:10.1016/j.arabjc.2013.03.003 .
Pejin, Boris, Iodice, Carmine, Bogdanović, Gordana, Kojić, Vesna, Tešević, Vele, "Stictic acid inhibits cell growth of human colon adenocarcinoma HT-29 cells" in Arabian Journal of Chemistry, 10 (2017):1240-1242, https://doi.org/10.1016/j.arabjc.2013.03.003 . .