New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity
2017
Аутори
Baroud, Afya A.Mihajlović-Lalić, Ljiljana
Stanković, Dalibor
Kajzerberger, Marijana
Van Hecke, Kristof
Grgurić-Šipka, Sanja
Savić, Aleksandar
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A new Ru(II) bipyridyl complex with O-4-hydrogenpyridine-2,4-dicarboxylate was synthesized and characterized by IR, NMR and mass spectrometry, X-ray diffraction analysis and elemental analysis. The electrochemical characteristics of the complex were investigated by cyclic voltammetry, revealing Ru(II)/Ru(III) electron transfer in the positive range of potentials. On the opposite potential side, multiple partially reversible peaks were dominant, representing subsequent reductions of the bulky bipyridyl moiety. The cytotoxic activity of the complex was tested in two human cancer cell lines: A549 (lung cancer) and K562 (leukemia) as well as non-tumor MRC-5 cells, by MTT assays. The IC50 values were gt 300 and 177.63+/-2.28 mu M for the A549 and K562 cells, respectively.
Кључне речи:
metal complex / characterization / X-ray / redox properties / biological studyИзвор:
Journal of the Serbian Chemical Society, 2017, 82, 3, 267-275Издавач:
- Serbian Chemical Soc, Belgrade
Финансирање / пројекти:
- Рационални дизајн и синтеза биолошки активних и координационих једињења и функционалних материјала, релевантних у (био)нанотехнологији (RS-MESTD-Basic Research (BR or ON)-172035)
- Strengthening of the MagBioVin Research and Innovation Team for Development of Novel Approaches for Tumour Therapy based on Nanostructured Materials (EU-FP7-621375)
- Research Foundation - Flanders (FWO) [1.5.216.15N]
- Hercules Foundation [AUGE/11/029]
DOI: 10.2298/JSC170109025B
ISSN: 0352-5139
WoS: 000401126100003
Scopus: 2-s2.0-85018254497
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Baroud, Afya A. AU - Mihajlović-Lalić, Ljiljana AU - Stanković, Dalibor AU - Kajzerberger, Marijana AU - Van Hecke, Kristof AU - Grgurić-Šipka, Sanja AU - Savić, Aleksandar PY - 2017 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2457 AB - A new Ru(II) bipyridyl complex with O-4-hydrogenpyridine-2,4-dicarboxylate was synthesized and characterized by IR, NMR and mass spectrometry, X-ray diffraction analysis and elemental analysis. The electrochemical characteristics of the complex were investigated by cyclic voltammetry, revealing Ru(II)/Ru(III) electron transfer in the positive range of potentials. On the opposite potential side, multiple partially reversible peaks were dominant, representing subsequent reductions of the bulky bipyridyl moiety. The cytotoxic activity of the complex was tested in two human cancer cell lines: A549 (lung cancer) and K562 (leukemia) as well as non-tumor MRC-5 cells, by MTT assays. The IC50 values were gt 300 and 177.63+/-2.28 mu M for the A549 and K562 cells, respectively. PB - Serbian Chemical Soc, Belgrade T2 - Journal of the Serbian Chemical Society T1 - New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity VL - 82 IS - 3 SP - 267 EP - 275 DO - 10.2298/JSC170109025B ER -
@article{ author = "Baroud, Afya A. and Mihajlović-Lalić, Ljiljana and Stanković, Dalibor and Kajzerberger, Marijana and Van Hecke, Kristof and Grgurić-Šipka, Sanja and Savić, Aleksandar", year = "2017", abstract = "A new Ru(II) bipyridyl complex with O-4-hydrogenpyridine-2,4-dicarboxylate was synthesized and characterized by IR, NMR and mass spectrometry, X-ray diffraction analysis and elemental analysis. The electrochemical characteristics of the complex were investigated by cyclic voltammetry, revealing Ru(II)/Ru(III) electron transfer in the positive range of potentials. On the opposite potential side, multiple partially reversible peaks were dominant, representing subsequent reductions of the bulky bipyridyl moiety. The cytotoxic activity of the complex was tested in two human cancer cell lines: A549 (lung cancer) and K562 (leukemia) as well as non-tumor MRC-5 cells, by MTT assays. The IC50 values were gt 300 and 177.63+/-2.28 mu M for the A549 and K562 cells, respectively.", publisher = "Serbian Chemical Soc, Belgrade", journal = "Journal of the Serbian Chemical Society", title = "New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity", volume = "82", number = "3", pages = "267-275", doi = "10.2298/JSC170109025B" }
Baroud, A. A., Mihajlović-Lalić, L., Stanković, D., Kajzerberger, M., Van Hecke, K., Grgurić-Šipka, S.,& Savić, A.. (2017). New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity. in Journal of the Serbian Chemical Society Serbian Chemical Soc, Belgrade., 82(3), 267-275. https://doi.org/10.2298/JSC170109025B
Baroud AA, Mihajlović-Lalić L, Stanković D, Kajzerberger M, Van Hecke K, Grgurić-Šipka S, Savić A. New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity. in Journal of the Serbian Chemical Society. 2017;82(3):267-275. doi:10.2298/JSC170109025B .
Baroud, Afya A., Mihajlović-Lalić, Ljiljana, Stanković, Dalibor, Kajzerberger, Marijana, Van Hecke, Kristof, Grgurić-Šipka, Sanja, Savić, Aleksandar, "New ruthenium(II) bipyridyl complex: Synthesis, crystal structure and cytotoxicity" in Journal of the Serbian Chemical Society, 82, no. 3 (2017):267-275, https://doi.org/10.2298/JSC170109025B . .