In vitro antimicrobial activity and cytotoxicity of nickel(II) complexes with different diamine ligands
2017
Autori
Drašković, Nenad S.Glišić, Biljana Đ.
Vojnović, Sandra
Nikodinović-Runić, Jasmina
Đuran, Miloš I.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Three diamines, 1,3-propanediamine (1,3-pd), 2,2-dimethyl-1,3-propanediamine (2,2-diMe-1,3-pd) and (+/-)-1,3-pentanediamine (1,3-pnd), were used for the synthesis of nickel(II) complexes 1-3, respectively, of the general formula [Ni(L)(2)(H2O)(2)]Cl-2. The stoichiometries of the complexes were confirmed by elemental microanalysis, and their structures were elucidated by spectroscopic (UV-Vis and IR) and molar conductivity measurements. The complexes 1-3, along with NiCl2 center dot 6H(2)O and the diamine ligands, were evaluated against a panel of microbial strains that are associated with skin, wound, urinary tract and nosocomial infections. The obtained results revealed no significant activity of 1-3 against the investigated bacterial strains. On the other hand, they showed good antifungal activity against pathogenic Candida strains, with minimum inhibitory concentration (MIC) values in the range from 15.6 to 62.5 mu g mL(-1). The best anti-Candida activity was observed for complex 2 ...against C. parapsilosis, while the least susceptible to the effect of the complexes was C. krusei. The antiproliferative effect on normal human lung fibro-blast cell line MRC-5 was also evaluated in order to determine the therapeutic potential of nickel(II) complexes 1-3. These complexes showed lower negative effects on the viability of the MRC-5 cell line than the clinically used nystatin and comparable selectivity indexes to that of this antifungal drug.
Ključne reči:
nickel(II) complexes / diamines / antimicrobial activity / Candida / cytotoxicityIzvor:
Journal of the Serbian Chemical Society, 2017, 82, 4, 389-398Izdavač:
- Serbian Chemical Soc, Belgrade
Finansiranje / projekti:
- Sinteza novih kompleksa metala i ispitivanje njihovih reakcija sa peptidima (RS-MESTD-Basic Research (BR or ON)-172036)
- Izučavanje mikrobiološkog diverziteta i karakterizacija korisnih sredinskih mikroorganizama (RS-MESTD-Basic Research (BR or ON)-173048)
DOI: 10.2298/JSC170113026D
ISSN: 0352-5139
WoS: 000404614300004
Scopus: 2-s2.0-85019366561
Kolekcije
Institucija/grupa
Inovacioni centar / Innovation CentreTY - JOUR AU - Drašković, Nenad S. AU - Glišić, Biljana Đ. AU - Vojnović, Sandra AU - Nikodinović-Runić, Jasmina AU - Đuran, Miloš I. PY - 2017 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2480 AB - Three diamines, 1,3-propanediamine (1,3-pd), 2,2-dimethyl-1,3-propanediamine (2,2-diMe-1,3-pd) and (+/-)-1,3-pentanediamine (1,3-pnd), were used for the synthesis of nickel(II) complexes 1-3, respectively, of the general formula [Ni(L)(2)(H2O)(2)]Cl-2. The stoichiometries of the complexes were confirmed by elemental microanalysis, and their structures were elucidated by spectroscopic (UV-Vis and IR) and molar conductivity measurements. The complexes 1-3, along with NiCl2 center dot 6H(2)O and the diamine ligands, were evaluated against a panel of microbial strains that are associated with skin, wound, urinary tract and nosocomial infections. The obtained results revealed no significant activity of 1-3 against the investigated bacterial strains. On the other hand, they showed good antifungal activity against pathogenic Candida strains, with minimum inhibitory concentration (MIC) values in the range from 15.6 to 62.5 mu g mL(-1). The best anti-Candida activity was observed for complex 2 against C. parapsilosis, while the least susceptible to the effect of the complexes was C. krusei. The antiproliferative effect on normal human lung fibro-blast cell line MRC-5 was also evaluated in order to determine the therapeutic potential of nickel(II) complexes 1-3. These complexes showed lower negative effects on the viability of the MRC-5 cell line than the clinically used nystatin and comparable selectivity indexes to that of this antifungal drug. PB - Serbian Chemical Soc, Belgrade T2 - Journal of the Serbian Chemical Society T1 - In vitro antimicrobial activity and cytotoxicity of nickel(II) complexes with different diamine ligands VL - 82 IS - 4 SP - 389 EP - 398 DO - 10.2298/JSC170113026D ER -
@article{ author = "Drašković, Nenad S. and Glišić, Biljana Đ. and Vojnović, Sandra and Nikodinović-Runić, Jasmina and Đuran, Miloš I.", year = "2017", abstract = "Three diamines, 1,3-propanediamine (1,3-pd), 2,2-dimethyl-1,3-propanediamine (2,2-diMe-1,3-pd) and (+/-)-1,3-pentanediamine (1,3-pnd), were used for the synthesis of nickel(II) complexes 1-3, respectively, of the general formula [Ni(L)(2)(H2O)(2)]Cl-2. The stoichiometries of the complexes were confirmed by elemental microanalysis, and their structures were elucidated by spectroscopic (UV-Vis and IR) and molar conductivity measurements. The complexes 1-3, along with NiCl2 center dot 6H(2)O and the diamine ligands, were evaluated against a panel of microbial strains that are associated with skin, wound, urinary tract and nosocomial infections. The obtained results revealed no significant activity of 1-3 against the investigated bacterial strains. On the other hand, they showed good antifungal activity against pathogenic Candida strains, with minimum inhibitory concentration (MIC) values in the range from 15.6 to 62.5 mu g mL(-1). The best anti-Candida activity was observed for complex 2 against C. parapsilosis, while the least susceptible to the effect of the complexes was C. krusei. The antiproliferative effect on normal human lung fibro-blast cell line MRC-5 was also evaluated in order to determine the therapeutic potential of nickel(II) complexes 1-3. These complexes showed lower negative effects on the viability of the MRC-5 cell line than the clinically used nystatin and comparable selectivity indexes to that of this antifungal drug.", publisher = "Serbian Chemical Soc, Belgrade", journal = "Journal of the Serbian Chemical Society", title = "In vitro antimicrobial activity and cytotoxicity of nickel(II) complexes with different diamine ligands", volume = "82", number = "4", pages = "389-398", doi = "10.2298/JSC170113026D" }
Drašković, N. S., Glišić, B. Đ., Vojnović, S., Nikodinović-Runić, J.,& Đuran, M. I.. (2017). In vitro antimicrobial activity and cytotoxicity of nickel(II) complexes with different diamine ligands. in Journal of the Serbian Chemical Society Serbian Chemical Soc, Belgrade., 82(4), 389-398. https://doi.org/10.2298/JSC170113026D
Drašković NS, Glišić BĐ, Vojnović S, Nikodinović-Runić J, Đuran MI. In vitro antimicrobial activity and cytotoxicity of nickel(II) complexes with different diamine ligands. in Journal of the Serbian Chemical Society. 2017;82(4):389-398. doi:10.2298/JSC170113026D .
Drašković, Nenad S., Glišić, Biljana Đ., Vojnović, Sandra, Nikodinović-Runić, Jasmina, Đuran, Miloš I., "In vitro antimicrobial activity and cytotoxicity of nickel(II) complexes with different diamine ligands" in Journal of the Serbian Chemical Society, 82, no. 4 (2017):389-398, https://doi.org/10.2298/JSC170113026D . .