Study of Homosalate Stability in Chlorinated Water and Identification Chalogenated By-Products by Gas Chromatography-Mass Spectrometry
Abstract
The increasing use of sun-creams containing organic UV-filters has led to increased concentration of these compounds in aquatic environment. Chlorinated water can convert these chemicals into chlorinated products whose toxic effects are of primary concern. The new compound may be more toxic than the starting primary compound. Many studies have shown that UV filters absorb UV light and decompose under solar irradiation, due to their unstable properties. This may lead to formation of certain by-products with harmful effects. Their decomposition products can cause allergic and toxic reactions to the human skin. This study follows the stability of most commonly used UV filters, homosalate, in conditions that include those existent in swimming pools. Stability of the homosalate in chlorinated water was studied in simulated swimming pool water samples. UV spectroscopy was used to follow the reaction of homosalate in presence of free chlorine. Water samples were filtered, acidified, and extra...cted by use of solid-phase extraction. Gas chromatography with mass spectrometry was used to identify the major transformation by-products. Under the experimental conditions, homosalate reacted with chlorine following zero order reaction. The chemical transformation of the homosalate in chlorinated water led to formation of chlorinated by-products that was identified as: monochloro-homosalate, dichloro-homosalate and two diastereoisomers monochloro-homosalate.
Keywords:
homosalate / free chlorine / solid phase extraction (SPE) / GC-MS / by-productsSource:
RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES, 2015, 6, 1, 990-1000Publisher:
- Rjpbcs Research Journal Pharmaceutical, Biological & Chemical Sciences, Proddatur
Collections
Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Imamovic, Belma AU - Trifunović, Snežana S. AU - Becic, Ervina AU - Dedic, Mirza AU - Sober, Miroslav PY - 2015 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2542 AB - The increasing use of sun-creams containing organic UV-filters has led to increased concentration of these compounds in aquatic environment. Chlorinated water can convert these chemicals into chlorinated products whose toxic effects are of primary concern. The new compound may be more toxic than the starting primary compound. Many studies have shown that UV filters absorb UV light and decompose under solar irradiation, due to their unstable properties. This may lead to formation of certain by-products with harmful effects. Their decomposition products can cause allergic and toxic reactions to the human skin. This study follows the stability of most commonly used UV filters, homosalate, in conditions that include those existent in swimming pools. Stability of the homosalate in chlorinated water was studied in simulated swimming pool water samples. UV spectroscopy was used to follow the reaction of homosalate in presence of free chlorine. Water samples were filtered, acidified, and extracted by use of solid-phase extraction. Gas chromatography with mass spectrometry was used to identify the major transformation by-products. Under the experimental conditions, homosalate reacted with chlorine following zero order reaction. The chemical transformation of the homosalate in chlorinated water led to formation of chlorinated by-products that was identified as: monochloro-homosalate, dichloro-homosalate and two diastereoisomers monochloro-homosalate. PB - Rjpbcs Research Journal Pharmaceutical, Biological & Chemical Sciences, Proddatur T2 - RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES T1 - Study of Homosalate Stability in Chlorinated Water and Identification Chalogenated By-Products by Gas Chromatography-Mass Spectrometry VL - 6 IS - 1 SP - 990 EP - 1000 UR - https://hdl.handle.net/21.15107/rcub_cherry_2542 ER -
@article{ author = "Imamovic, Belma and Trifunović, Snežana S. and Becic, Ervina and Dedic, Mirza and Sober, Miroslav", year = "2015", abstract = "The increasing use of sun-creams containing organic UV-filters has led to increased concentration of these compounds in aquatic environment. Chlorinated water can convert these chemicals into chlorinated products whose toxic effects are of primary concern. The new compound may be more toxic than the starting primary compound. Many studies have shown that UV filters absorb UV light and decompose under solar irradiation, due to their unstable properties. This may lead to formation of certain by-products with harmful effects. Their decomposition products can cause allergic and toxic reactions to the human skin. This study follows the stability of most commonly used UV filters, homosalate, in conditions that include those existent in swimming pools. Stability of the homosalate in chlorinated water was studied in simulated swimming pool water samples. UV spectroscopy was used to follow the reaction of homosalate in presence of free chlorine. Water samples were filtered, acidified, and extracted by use of solid-phase extraction. Gas chromatography with mass spectrometry was used to identify the major transformation by-products. Under the experimental conditions, homosalate reacted with chlorine following zero order reaction. The chemical transformation of the homosalate in chlorinated water led to formation of chlorinated by-products that was identified as: monochloro-homosalate, dichloro-homosalate and two diastereoisomers monochloro-homosalate.", publisher = "Rjpbcs Research Journal Pharmaceutical, Biological & Chemical Sciences, Proddatur", journal = "RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES", title = "Study of Homosalate Stability in Chlorinated Water and Identification Chalogenated By-Products by Gas Chromatography-Mass Spectrometry", volume = "6", number = "1", pages = "990-1000", url = "https://hdl.handle.net/21.15107/rcub_cherry_2542" }
Imamovic, B., Trifunović, S. S., Becic, E., Dedic, M.,& Sober, M.. (2015). Study of Homosalate Stability in Chlorinated Water and Identification Chalogenated By-Products by Gas Chromatography-Mass Spectrometry. in RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES Rjpbcs Research Journal Pharmaceutical, Biological & Chemical Sciences, Proddatur., 6(1), 990-1000. https://hdl.handle.net/21.15107/rcub_cherry_2542
Imamovic B, Trifunović SS, Becic E, Dedic M, Sober M. Study of Homosalate Stability in Chlorinated Water and Identification Chalogenated By-Products by Gas Chromatography-Mass Spectrometry. in RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES. 2015;6(1):990-1000. https://hdl.handle.net/21.15107/rcub_cherry_2542 .
Imamovic, Belma, Trifunović, Snežana S., Becic, Ervina, Dedic, Mirza, Sober, Miroslav, "Study of Homosalate Stability in Chlorinated Water and Identification Chalogenated By-Products by Gas Chromatography-Mass Spectrometry" in RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES, 6, no. 1 (2015):990-1000, https://hdl.handle.net/21.15107/rcub_cherry_2542 .