The analysis of 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles under an external magnetic field and their radiolabeling for possible theranostic applications
Authorized Users Only
2019
Authors
Perić, MarkoRadović, Magdalena
Mirković, Marija D.
Nikolić, Aleksandar S.
Iskrenović, Predrag
Janković, Drina
Vranješ-Đurić, Sanja
Article (Published version)
Metadata
Show full item recordAbstract
The advances in nanotechnology are directed towards the development of new theranostic agents based on magnetic nanoparticles that can be used for both cancer detection and treatment. In this study, 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles (Fe 3 O 4 -DPD MNPs) were evaluated for their theranostic application using different methods. The magnetic hyperthermia efficiency of the Fe 3 O 4 -DPD MNPs was investigated in saline solution with ionic strengths between 0.05 and 1.0 mol dm −3 . For a better understanding of hyperthermia, the behavior of Fe 3 O 4 -DPD MNPs under a non-alternating magnetic field was studied, and the transparency of the sample was measured. Furthermore, the radiotracer method using the radionuclides 99m Tc and 90 Y was applied as a reliable and powerful method for evaluating the in vivo behavior of a nanoprobe; a high radiolabeling yield (>93%), in vitro and in vivo stability of the radiolabeled nanoparticles and high heating effec...t were observed, thus paving the way for the possible theranostic applications of Fe 3 O 4 -DPD MNPs.
Source:
New Journal of Chemistry, 2019, 43, 15, 5932-5939Publisher:
- The Royal Society of Chemistry
Funding / projects:
- Magnetic and radionuclide labeled nanostructured materials for medical applications (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45015)
- Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology (RS-MESTD-Basic Research (BR or ON)-172035)
- Diagnostics and Optimization of Plasma Sources Important for Applications (RS-MESTD-Basic Research (BR or ON)-171034)
Note:
- Peer-reviewed manuscript: http://cherry.chem.bg.ac.rs/handle/123456789/2911
DOI: 10.1039/c8nj06478d
ISSN: 1144-0546
WoS: 000465240500031
Scopus: 2-s2.0-85064107332
Collections
Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Perić, Marko AU - Radović, Magdalena AU - Mirković, Marija D. AU - Nikolić, Aleksandar S. AU - Iskrenović, Predrag AU - Janković, Drina AU - Vranješ-Đurić, Sanja PY - 2019 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2910 AB - The advances in nanotechnology are directed towards the development of new theranostic agents based on magnetic nanoparticles that can be used for both cancer detection and treatment. In this study, 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles (Fe 3 O 4 -DPD MNPs) were evaluated for their theranostic application using different methods. The magnetic hyperthermia efficiency of the Fe 3 O 4 -DPD MNPs was investigated in saline solution with ionic strengths between 0.05 and 1.0 mol dm −3 . For a better understanding of hyperthermia, the behavior of Fe 3 O 4 -DPD MNPs under a non-alternating magnetic field was studied, and the transparency of the sample was measured. Furthermore, the radiotracer method using the radionuclides 99m Tc and 90 Y was applied as a reliable and powerful method for evaluating the in vivo behavior of a nanoprobe; a high radiolabeling yield (>93%), in vitro and in vivo stability of the radiolabeled nanoparticles and high heating effect were observed, thus paving the way for the possible theranostic applications of Fe 3 O 4 -DPD MNPs. PB - The Royal Society of Chemistry T2 - New Journal of Chemistry T1 - The analysis of 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles under an external magnetic field and their radiolabeling for possible theranostic applications VL - 43 IS - 15 SP - 5932 EP - 5939 DO - 10.1039/c8nj06478d ER -
@article{ author = "Perić, Marko and Radović, Magdalena and Mirković, Marija D. and Nikolić, Aleksandar S. and Iskrenović, Predrag and Janković, Drina and Vranješ-Đurić, Sanja", year = "2019", abstract = "The advances in nanotechnology are directed towards the development of new theranostic agents based on magnetic nanoparticles that can be used for both cancer detection and treatment. In this study, 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles (Fe 3 O 4 -DPD MNPs) were evaluated for their theranostic application using different methods. The magnetic hyperthermia efficiency of the Fe 3 O 4 -DPD MNPs was investigated in saline solution with ionic strengths between 0.05 and 1.0 mol dm −3 . For a better understanding of hyperthermia, the behavior of Fe 3 O 4 -DPD MNPs under a non-alternating magnetic field was studied, and the transparency of the sample was measured. Furthermore, the radiotracer method using the radionuclides 99m Tc and 90 Y was applied as a reliable and powerful method for evaluating the in vivo behavior of a nanoprobe; a high radiolabeling yield (>93%), in vitro and in vivo stability of the radiolabeled nanoparticles and high heating effect were observed, thus paving the way for the possible theranostic applications of Fe 3 O 4 -DPD MNPs.", publisher = "The Royal Society of Chemistry", journal = "New Journal of Chemistry", title = "The analysis of 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles under an external magnetic field and their radiolabeling for possible theranostic applications", volume = "43", number = "15", pages = "5932-5939", doi = "10.1039/c8nj06478d" }
Perić, M., Radović, M., Mirković, M. D., Nikolić, A. S., Iskrenović, P., Janković, D.,& Vranješ-Đurić, S.. (2019). The analysis of 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles under an external magnetic field and their radiolabeling for possible theranostic applications. in New Journal of Chemistry The Royal Society of Chemistry., 43(15), 5932-5939. https://doi.org/10.1039/c8nj06478d
Perić M, Radović M, Mirković MD, Nikolić AS, Iskrenović P, Janković D, Vranješ-Đurić S. The analysis of 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles under an external magnetic field and their radiolabeling for possible theranostic applications. in New Journal of Chemistry. 2019;43(15):5932-5939. doi:10.1039/c8nj06478d .
Perić, Marko, Radović, Magdalena, Mirković, Marija D., Nikolić, Aleksandar S., Iskrenović, Predrag, Janković, Drina, Vranješ-Đurić, Sanja, "The analysis of 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles under an external magnetic field and their radiolabeling for possible theranostic applications" in New Journal of Chemistry, 43, no. 15 (2019):5932-5939, https://doi.org/10.1039/c8nj06478d . .