Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata
Samo za registrovane korisnike
2019
Autori
Novaković, Miroslav M.Bukvicki, Danka
Anđelković, Boban D.
Ilić-Tomić, Tatjana
Veljić, Milan
Tešević, Vele
Asakawa, Yoshinori
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Seven new bisbibenzyls (1-7) were isolated from the methanol extract of the liverwort Lunularia cruciata along with one previously known bibenzyl and five known bisbibenzyls. The structures of compounds 1-7 were elucidated on the basis of the spectroscopic data. These newly isolated bisbibenzyls may be divided into two groups, the acyclic bisbibenzyls, perrottetins (1-3), and the cyclic analogues, riccardins (4-7). Besides standard perrottetin and riccardin structures (1 and 4, respectively), they contain phenanthrene (3 and 5), dihydrophenanthrene (2), and quinone moieties (6 and 7), rarely found in natural products. The new compounds 3 and 5, as well as the known riccardin G, exhibited cytotoxic activity against the A549 lung cancer cell line with IC 50 values of 5.0, 5.0, and 2.5 μM, respectively.
Izvor:
Journal of Natural Products, 2019, 82, 4, 694-701Izdavač:
- American Chemical Society and American Society of Pharmacognosy
Finansiranje / projekti:
- Bioaktivni prirodni proizvodi samoniklih, gajenih i jestivih biljaka: određivanje struktura i aktivnosti (RS-MESTD-Basic Research (BR or ON)-172053)
- Mikromorfološka, fitohemijska i molekularna istraživanja biljaka - sistematski, ekološki i primenljivi aspekti (RS-MESTD-Basic Research (BR or ON)-173029)
- Izučavanje mikrobiološkog diverziteta i karakterizacija korisnih sredinskih mikroorganizama (RS-MESTD-Basic Research (BR or ON)-173048)
Napomena:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3097
DOI: 10.1021/acs.jnatprod.8b00390
ISSN: 0163-3864
WoS: 000466442100002
Scopus: 2-s2.0-85062828630
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Novaković, Miroslav M. AU - Bukvicki, Danka AU - Anđelković, Boban D. AU - Ilić-Tomić, Tatjana AU - Veljić, Milan AU - Tešević, Vele AU - Asakawa, Yoshinori PY - 2019 UR - https://cherry.chem.bg.ac.rs/handle/123456789/3096 AB - Seven new bisbibenzyls (1-7) were isolated from the methanol extract of the liverwort Lunularia cruciata along with one previously known bibenzyl and five known bisbibenzyls. The structures of compounds 1-7 were elucidated on the basis of the spectroscopic data. These newly isolated bisbibenzyls may be divided into two groups, the acyclic bisbibenzyls, perrottetins (1-3), and the cyclic analogues, riccardins (4-7). Besides standard perrottetin and riccardin structures (1 and 4, respectively), they contain phenanthrene (3 and 5), dihydrophenanthrene (2), and quinone moieties (6 and 7), rarely found in natural products. The new compounds 3 and 5, as well as the known riccardin G, exhibited cytotoxic activity against the A549 lung cancer cell line with IC 50 values of 5.0, 5.0, and 2.5 μM, respectively. PB - American Chemical Society and American Society of Pharmacognosy T2 - Journal of Natural Products T1 - Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata VL - 82 IS - 4 SP - 694 EP - 701 DO - 10.1021/acs.jnatprod.8b00390 ER -
@article{ author = "Novaković, Miroslav M. and Bukvicki, Danka and Anđelković, Boban D. and Ilić-Tomić, Tatjana and Veljić, Milan and Tešević, Vele and Asakawa, Yoshinori", year = "2019", abstract = "Seven new bisbibenzyls (1-7) were isolated from the methanol extract of the liverwort Lunularia cruciata along with one previously known bibenzyl and five known bisbibenzyls. The structures of compounds 1-7 were elucidated on the basis of the spectroscopic data. These newly isolated bisbibenzyls may be divided into two groups, the acyclic bisbibenzyls, perrottetins (1-3), and the cyclic analogues, riccardins (4-7). Besides standard perrottetin and riccardin structures (1 and 4, respectively), they contain phenanthrene (3 and 5), dihydrophenanthrene (2), and quinone moieties (6 and 7), rarely found in natural products. The new compounds 3 and 5, as well as the known riccardin G, exhibited cytotoxic activity against the A549 lung cancer cell line with IC 50 values of 5.0, 5.0, and 2.5 μM, respectively.", publisher = "American Chemical Society and American Society of Pharmacognosy", journal = "Journal of Natural Products", title = "Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata", volume = "82", number = "4", pages = "694-701", doi = "10.1021/acs.jnatprod.8b00390" }
Novaković, M. M., Bukvicki, D., Anđelković, B. D., Ilić-Tomić, T., Veljić, M., Tešević, V.,& Asakawa, Y.. (2019). Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata. in Journal of Natural Products American Chemical Society and American Society of Pharmacognosy., 82(4), 694-701. https://doi.org/10.1021/acs.jnatprod.8b00390
Novaković MM, Bukvicki D, Anđelković BD, Ilić-Tomić T, Veljić M, Tešević V, Asakawa Y. Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata. in Journal of Natural Products. 2019;82(4):694-701. doi:10.1021/acs.jnatprod.8b00390 .
Novaković, Miroslav M., Bukvicki, Danka, Anđelković, Boban D., Ilić-Tomić, Tatjana, Veljić, Milan, Tešević, Vele, Asakawa, Yoshinori, "Cytotoxic Activity of Riccardin and Perrottetin Derivatives from the Liverwort Lunularia cruciata" in Journal of Natural Products, 82, no. 4 (2019):694-701, https://doi.org/10.1021/acs.jnatprod.8b00390 . .